Abstract: The present invention generally relates to at least one precursor compound and derivatives thereof, a process for preparing a taxane, and a baccatin derivative.
Type:
Grant
Filed:
March 7, 2007
Date of Patent:
October 7, 2008
Assignee:
Societe d'Etude et de Recherche En Ingenierie Pharmaceutique-Seripharm
Inventors:
Luc Chanteloup, Bruno Chauveau, Christina Corbin, Robert Dhal, Sonia Le Guen, Arnaud Lamy, Antoine Leze, Jean-Pierre Robin
Abstract: The present invention generally relates to at least one precursor compound and derivatives thereof, a process for preparing a taxane, and a baccatin derivative.
Type:
Grant
Filed:
June 4, 2004
Date of Patent:
October 9, 2007
Assignee:
Societe d'etude et de Recherche en Ingenierie Pharmaceutique Seripharm
Inventors:
Luc Chanteloup, Bruno Chauveau, Christine Corbin, Robert Dhal, Sonia Le Guen, Arnaud Lamy, Antoine Leze, Jean-Pierre Robin
Abstract: The present invention generally relates to at least one precursor compound and derivatives thereof, a process for preparing a taxane, and a baccatin derivative.
Type:
Grant
Filed:
March 11, 2005
Date of Patent:
May 22, 2007
Assignee:
Societe d'etude et de Recherche en Ingenierie Pharmaceutique Seripharm
Inventors:
Luc Chanteloup, Bruno Chauveau, Christine Corbin, Robert Dhal, Sonia Le Guen, Arnaud Lamy, Antoine Leze, Jean-Pierre Robin
Abstract: The present invention relates to novel intermediates for the hemisynthesis of taxanes and to their processes of preparation. The compounds of the present invention include precursor compounds of taxane side chains.
Type:
Application
Filed:
April 18, 2001
Publication date:
June 6, 2002
Applicant:
Societe d'Etude et de Recherche en Ingenierie Pharmaceutique Seripharm
Inventors:
Luc Chanteloup, Bruno Chauveau, Christine Corbin, Robert Dhal, Sonia Le Guen, Arnaud Lamy, Antoine Leze, Jean-Pierre Robin
Abstract: The present invention relates to new intermediates for the semisynthesis of taxanes and their preparation processes. It relates to derivatives of oxazolidines or oxazolidinones, as well as to new derivatives of baccatine III. The general process for the synthesis of taxanes according to the invention enables to obtain a product such as PACLITAXEL in only five steps from products available in the market, compared to nine steps in general, for processes of the prior art.
Type:
Grant
Filed:
April 27, 1998
Date of Patent:
July 24, 2001
Assignee:
Societe d'Etude et de Recherche en Ingenierie Pharmaceutique
Seripharm
Inventors:
Luc Chanteloup, Bruno Chauveau, Christine Corbin, Robert Dhal, Sonia Le Guen, Arnaud Lamy, Antoine Leze, Jean-Pierre Robin
Abstract: New processes for the selective protection of the 7-position of 7,10-dihydroxytaxane derivatives, using &bgr;-substituted-alkoxycarbonyl groups which are more hindered than 2,2,2-trichloroethoxycarbonyl, and which are capable of being removed by a &bgr;-elimination mechanism, and the new intermediates resulting from these processes. The new intermediates of the invention are useful for preparing taxol and analogs thereof.
Type:
Grant
Filed:
May 19, 1998
Date of Patent:
January 30, 2001
Assignee:
Societe d'Etude et de Recherche en Ingenierie Pharmaceutique
Seripharm
Inventors:
Luc Chanteloup, Bruno Chauveau, Christine Corbin, Robert Dhal, Sonia Le Guen, Arnaud Lamy, Antoine Leze, Jean-Pierre Robin