Patents Assigned to Societe d'Etudes Scientifiques et Industrielle de l'Ile de France
  • Process for producing enamines
    Patent number: 4166060
    Abstract: Enamines which are employed to obtain benzamides effective in the treatment of emesis are produced by efficient processes.
    Type: Grant
    Filed: December 21, 1977
    Date of Patent: August 28, 1979
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
    Inventors: Gerard Bulteau, Jacques Acher, Jean-Claude Monier
  • N-(1'-ethyl-2'-oxo-5'-pyrrolidinylmethyl) benzamide compounds and derivatives, method of preparation and pharmaceutical preparations
    Patent number: 4161532
    Abstract: Novel substituted N-(1'-ethyl-2'-oxo-5'-pyrrolidinylmethyl) benzamide comnds and derivatives thereof are disclosed. The compounds have psychotropic properties and may be used in pharmaceutical compositions as behavior modifiers.
    Type: Grant
    Filed: April 14, 1978
    Date of Patent: July 17, 1979
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile de France
    Inventors: Gerard Bulteau, Jacques Acher, Jean C. Monier
  • Enamines, their derivatives and processes of production
    Patent number: 4077976
    Abstract: The enamines of this invention are useful in the preparation of certain benzamides employed in the treatment of emesis in mammals.
    Type: Grant
    Filed: June 11, 1976
    Date of Patent: March 7, 1978
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
    Inventors: Gerard Bulteau, Jacques Acher, Jean-Claude Monier
  • N-(1'-Allypyrrolidinyl 2'-methyl) 2-methoxy 4,5-azimido benzamide and its pharmaceutically acceptable salts
    Patent number: 4039672
    Abstract: The azimido benzamide of this invention and its pharmaceutically acceptable salts have an unusually and unexpectedly high therapeutic index and low toxicity in the treatment of emesis in mammals. Pharmacological testing demonstrated the superior efficacy of the compound of this invention over known, similar compounds.
    Type: Grant
    Filed: March 3, 1975
    Date of Patent: August 2, 1977
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
    Inventors: Gerard Bulteau, Jacques Acher, Claude Collignon, Jean-Claude Monier
  • N-(1-benzyl pyrrolidinyl 2-alkyl) substituted benzamides and derivatives thereof
    Patent number: 4029673
    Abstract: The benzamides of this invention and their pharmaceutically acceptable salts are particularly effective in the treatment of emesis and ulcers in mammals. Their low level of toxicity is compatible with use in human therapy, without undesirable side effects.
    Type: Grant
    Filed: March 5, 1975
    Date of Patent: June 14, 1977
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
    Inventors: Gerard Bulteau, Jacques Acher, Jean-Claude Monier
  • Methods of treating a mammal afflicted with hypotension with dialkylaminoalkyl ethers of 2-alkoxy-3,5-dihalobenzene and salts thereof
    Patent number: 3995038
    Abstract: Hypotension in mammals is effective relieved by the administration of dialkylaminoalkyl ethers of 2-alkoxy-3,5-dihalobenzenes. The compounds are relatively non-toxic in dosages required to alleviate such conditions.
    Type: Grant
    Filed: April 26, 1976
    Date of Patent: November 30, 1976
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
    Inventor: Michel Leon Thominet
  • Methods of treating a mammal afflicted with excessive histamine with dialkylaminoalkyl ethers of 2-alkoxy-3,5-dihalobenzene and salts thereof
    Patent number: 3995036
    Abstract: Excessive histamine in mammals is effectively relieved by the administration of dialkylaminoalkyl ethers of 2-alkoxy-3,5-dihalobenzenes. The compounds are relatively non-toxic in dosages required to alleviate such condition.
    Type: Grant
    Filed: April 26, 1976
    Date of Patent: November 30, 1976
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
    Inventor: Michel Leon Thominet
  • Methods of treating a mammal afflicted with pain with dialkylaminoalkyl ethers of 2-alkoxy-3,5-dihalobenzene and salts thereof
    Patent number: 3995037
    Abstract: Pain in mammals is effectively relieved by the administration of dialkylaminoalkyl ethers of 2-alkoxy-3,5-dihalobenzenes. The compounds are relatively non-toxic in dosages required to alleviate such condition.
    Type: Grant
    Filed: April 26, 1976
    Date of Patent: November 30, 1976
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
    Inventor: Michel Leon Thominet
  • Methods of treating a mammal afflicted with convulsions, with dialkylaminoalkyl ethers of 2-alkoxy-3,5-dihalobenzene and salts thereof
    Patent number: 3978218
    Abstract: Convulsions, pain, excessive histamine or hypotension in mammals are effectively relieved by the administration of dialkylaminoalkyl ethers of 2-alkoxy-3,5-dihalobenzenes. The compounds are relatively non-toxic in dosages required to alleviate such conditions.
    Type: Grant
    Filed: May 13, 1975
    Date of Patent: August 31, 1976
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
    Inventor: Michel Leon Thominet
  • Processes of producing 2,5-disubstituted benzamides
    Patent number: 3975434
    Abstract: 2,5-Disubstituted benzamides are produced by an efficient, effective and economical method by the utilization of 4-methyl 2-chloro 1-3-2-dioxophosphorinane as a catalyst.
    Type: Grant
    Filed: September 23, 1974
    Date of Patent: August 17, 1976
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
    Inventors: Gerard Bulteau, Jacques Acher, Jean-Claude Monier
  • Methods of protection against emesis in mammals by administration of a heterocyclic benzamide
    Patent number: 3959477
    Abstract: The heterocyclic benzamides of this invention are particularly effective for the treatment of emesis in mammals. For example, when they are administered to dogs in relatively small dosage, they afford 100% protection against vomiting. They are also non-toxic in dosages for effecting complete control of vomiting.
    Type: Grant
    Filed: March 24, 1975
    Date of Patent: May 25, 1976
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
    Inventor: Michel Leon Thominet
  • 3-Alkoxy-thianapthene-2-carboxamides
    Patent number: 3954748
    Abstract: The 3-alkoxy-thianaphthene-2-carboxamides of this invention are effective for the treatment of mammals afflicted with emesis. When administered to dogs in dosages of 250 .mu.g/kg, compounds of this invention give 100% protection against vomiting normally induced by subcutaneous administration of apomorphine. The compounds of this invention also favorably modify behavior disturbances in mammals.
    Type: Grant
    Filed: June 26, 1974
    Date of Patent: May 4, 1976
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
    Inventor: Michel Leon Thominet