Abstract: The invention relates to the use of benzamide derivatives of the formula: ##STR1## in which: A is a diethylaminoethyl group or a group of the formula II: ##STR2## where R is a C.sub.1 -C.sub.3 alkyl, allyl, cyclopropylmethyl or cyclohexenylmethyl group,X is a chlorine or bromine atom, andZ is --NH-- or --O-- with the following condition: when Z is --O--, A is a diethylaminoethyl group, and their pharmacologically acceptable salts for the preparation of medicinal products which are useful in the treatment and prevention of disorders of the cognitive function.
Type:
Grant
Filed:
April 12, 1990
Date of Patent:
May 5, 1992
Assignee:
Societe d'Etudes Scientifiques et Industrielles de L'Ile-de-France
Inventors:
Jacques Acher, Jean-Claude Monier, Jean-Paul Schmitt, Renee Gardaix-Luthereau, Brenda Costall, Robert Naylor
Abstract: New substituted benzamides have the general formula: ##STR1## A=alkyl, alkenyl, diethylaminoethyl or ##STR2## R.sub.1, R.sub.2 =H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl; R.sub.3, R.sub.4, R.sub.5, R.sub.6 =hydrogen or C.sub.1 -C.sub.6 alkyl;X=halogen;Y=H, halogen;Z=NH, oxygen or sulfur;their optical isomers and their physiologically acceptable salts. The compounds are used as activators of the central nervous system.
Type:
Grant
Filed:
December 19, 1986
Date of Patent:
May 30, 1989
Assignee:
Societe D'Etudes Scientifiques et Industrielles de L'Ile-de-France
Inventors:
Jacques Acher, Jean-Claude Monier, Jean-Paul Schmitt, Renee Gardaix-Luthereau, Brenda Costall, Robert Naylor
Abstract: The invention concerns novel benzamides and their pharmacologically acceptable salts which are useful as gastromotor agents and correspond to the following general formula (I): ##STR1## in which: R.sub.1 is lower alkyl, lower alkenyl or a hydrogen atom;R.sub.2 is alkyl, lower alkenyl, benzyl, cycloalkylalkyl, cycloalkenylalkyl or a hydrogen atom;R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 each are lower alkyl or a hydrogen atom, andX is a halogen atom.
Type:
Grant
Filed:
July 7, 1986
Date of Patent:
October 27, 1987
Assignee:
Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
Abstract: A method is provided for rapidly screening candidates for precancerous atrophic H. gastritis by visualizing the presence of a hypoacidity condition of the gastric mucous membrane by applying droplets of an indicator to the stomach wall which indicator undergoes a marked color change in the presence of a hypoacidic condition and then detecting immediately the presence of that color change. The indicator employed is bromocresol green, bromophenol blue or bromochlorophenol blue.
Type:
Grant
Filed:
November 19, 1982
Date of Patent:
April 28, 1987
Assignee:
Societe d'Etudes Scientifiques et Industrielles de l'Ile de France
Abstract: The invention relates to a contraceptive composition of a prolactin elevag benzamide, such as N-[(1-ethyl-2-pyrrolidinyl)methyl]2-methoxy 5-sulfamoyl benzamide, and a progestogen.
Type:
Grant
Filed:
October 10, 1985
Date of Patent:
January 27, 1987
Assignee:
Societe d'Etudes Scientifiques et Industrielles de l'Ile de France
Abstract: N-(1-allyl-2-pyrrolidinylmethyl) 2-methoxy-4-amino-5-methylsulphamoyl benzamide and its pharmacologically acceptable salts thereof are taught to be useful in treating a subject suffering from platelet dysfunction in thrombo-embolic disorders.
Type:
Grant
Filed:
August 7, 1984
Date of Patent:
August 19, 1986
Assignee:
Societe d'Etudes Scientifiques et Industrielles de l'Ile-De-France
Abstract: The present invention concerns compound useful as intermediates in the preparation of heterocyclic phenoxy amines of the formula ##STR1## wherein Y is hydroxyl or chlorine and R is 1-cyclohexenylmethyl.
Type:
Grant
Filed:
January 7, 1983
Date of Patent:
June 10, 1986
Assignee:
Societe d'Etudes Scientifiques et Industrielles de L'ile-de-France
Inventors:
Michel L. Thominet, Jacqueline F. Franceschini
Abstract: N-(1-allyl-2-pyrrolidinyl-methyl) 2-methoxy-4-amino-5-methylsulfamoyl benide and derivatives thereof, which are useful in the treatment of anomalies in cerebral hemodynamics of patients subject to migraines.
Type:
Grant
Filed:
February 15, 1983
Date of Patent:
October 29, 1985
Assignee:
Societe d'Etudes Scientifiques et Industrielles de l'Ile-de France
Abstract: N-(1'-allyl-2'-pyrrolidylmethyl)-2,3-dimethoxy-5-sulfamoylbenzamide and dvatives thereof and method for treating the psycho neuro-vegetative syndrome of the natural or surgical menopause by administering an effective amount of said compound to a patient.
Type:
Grant
Filed:
October 13, 1983
Date of Patent:
February 12, 1985
Assignee:
Societe D'Etudes Scientifiques et Industrielles de l'Ile de France
Abstract: N-(1-allyl-2-pyrrolidinyl-methyl)2-methoxy-4-amino-5-methylsulfamoyl benzde and derivatives thereof, which are useful in the treatment of anomalies in cerebral hemodynamics of patients subject to migraines.
Type:
Grant
Filed:
August 25, 1981
Date of Patent:
September 20, 1983
Assignee:
Societe d'Etudes Scientifiques et Industrielles de l'Ile-de France
Abstract: The present invention relates to a novel veratramide, N-(1-methyl-2-pyrroinyl-methyl)-2,3-dimethoxy-5-methylsulphamoyl benzamide, its pharmacologically acceptable acid addition salts, its quaternary ammonium salts, its oxides and its levorotatory and dextrorotatory isomers and their use in the treatment of disorders of the lower urinary apparatus.
Type:
Grant
Filed:
December 11, 1980
Date of Patent:
December 21, 1982
Assignee:
Societe d'Etudes Scientifiques et Industrielles de l'Ile de France
Abstract: Novel substituted 2,3-alkylene bis (oxy) benzamides and derivatives thereof are disclosed. Also disclosed is a method for producing said compounds. The compounds have anxiolytic, psychostimulant, disinhibiting and thymoanaleptic properties useful therapeutically in the psychofunctional field, particularly in gastro-enterology, cardiology, urology, rheumatology and gynaecology.
Type:
Grant
Filed:
June 12, 1979
Date of Patent:
April 6, 1982
Assignee:
Societe d'Etudes Scientifiques et Industrielles de L'ile-de-France
Inventors:
Michel Thominet, Gerard Bulteau, Jacques Acher, Claude Collignon
Abstract: There are provided certain N-(1-lower alkyl-2-pyrrolidylmethyl)2-lower aly-4-amino-5-lower alkyl sulphonyl benzamides and derivatives thereof which provide surprising antiapomorphine and antiserotonin activity.
Type:
Grant
Filed:
January 18, 1979
Date of Patent:
October 13, 1981
Assignee:
Societe d'Etudes Scientifiques et Industrielles de l'Ile de-France
Inventors:
Michel Thominet, Jacques Acher, Jean-Claude Monier
Abstract: Novel substituted 2,3-alkylene bis (oxy) benzamides and derivatives thereof are disclosed. Also disclosed is a method for producing said compounds. The compounds have anxiolytic, psychostimulant, disinhibiting and thymoanaleptic properties useful therapeutically in the psychofunctional field, particularly in gastro-enterology, cardiology, urology, rheumatology and gynaecology.
Type:
Grant
Filed:
February 23, 1979
Date of Patent:
May 19, 1981
Assignee:
Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
Inventors:
Michel Thominet, Gerard Bulteau, Jacques Acher, Claude Collignon
Abstract: The present invention relates to a novel veratramide, N-(1-methyl-2-pyrroinyl-methyl)-2,3-dimethoxy-5-methylsulphamoyl benzamide, its pharmacologically acceptable acid addition salts, its quaternary ammonium salts, its oxides and its levorotatory and dextrorotatory isomers and their use in the treatment of disorders of the lower urinary apparatus.
Type:
Grant
Filed:
October 5, 1979
Date of Patent:
April 21, 1981
Assignee:
Societe d'Etudes Scientifiques et Industrielles de l'Ile de France
Abstract: Novel substituted 2,3-alkylene bis (oxy) benzamides and derivatives thereof are disclosed. Also disclosed is a method for producing said compounds. The compounds have anxiolytic, psychostimulant, disinhibiting and thymoanaleptic properties useful therapeutically in the psychofunctional field, particularly in gastro-enterology, cardiology, urology, rheumatology and gynaecology.
Type:
Grant
Filed:
February 23, 1979
Date of Patent:
February 3, 1981
Assignee:
Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
Inventors:
Michel Thominet, Gerard Bulteau, Jacques Acher, Claude Collignon
Abstract: Novel substituted 2,3-alkylene bis (oxy) benzamides and derivatives thereof are disclosed. Also disclosed is a method for producing said compounds. The compounds have anxiolytic, psychostimulant, disinhibiting and thymoanaleptic properties useful therapeutically in the psychofunctional field, particularly in gastro-enterology, cardiology, urology, rheumatology and gynaecology.
Type:
Grant
Filed:
August 2, 1977
Date of Patent:
January 29, 1980
Assignee:
Societe D'Etudes Scientifiques et Industrielles de L'ile-de-France
Inventors:
Michel Thominet, Gerard Bulteau, Jacques Acher, Claude Collignon