Patents Assigned to Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
  • Patent number: 5110824
    Abstract: The invention relates to the use of benzamide derivatives of the formula: ##STR1## in which: A is a diethylaminoethyl group or a group of the formula II: ##STR2## where R is a C.sub.1 -C.sub.3 alkyl, allyl, cyclopropylmethyl or cyclohexenylmethyl group,X is a chlorine or bromine atom, andZ is --NH-- or --O-- with the following condition: when Z is --O--, A is a diethylaminoethyl group, and their pharmacologically acceptable salts for the preparation of medicinal products which are useful in the treatment and prevention of disorders of the cognitive function.
    Type: Grant
    Filed: April 12, 1990
    Date of Patent: May 5, 1992
    Assignee: Societe d'Etudes Scientifiques et Industrielles de L'Ile-de-France
    Inventors: Jacques Acher, Jean-Claude Monier, Jean-Paul Schmitt, Renee Gardaix-Luthereau, Brenda Costall, Robert Naylor
  • Patent number: 4835172
    Abstract: New substituted benzamides have the general formula: ##STR1## A=alkyl, alkenyl, diethylaminoethyl or ##STR2## R.sub.1, R.sub.2 =H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl; R.sub.3, R.sub.4, R.sub.5, R.sub.6 =hydrogen or C.sub.1 -C.sub.6 alkyl;X=halogen;Y=H, halogen;Z=NH, oxygen or sulfur;their optical isomers and their physiologically acceptable salts. The compounds are used as activators of the central nervous system.
    Type: Grant
    Filed: December 19, 1986
    Date of Patent: May 30, 1989
    Assignee: Societe D'Etudes Scientifiques et Industrielles de L'Ile-de-France
    Inventors: Jacques Acher, Jean-Claude Monier, Jean-Paul Schmitt, Renee Gardaix-Luthereau, Brenda Costall, Robert Naylor
  • Patent number: 4762852
    Abstract: The compound of N-(1-cyclohexenylmethyl)2-pyrrolidinymethyl 8-ethylsulphonyl-1,5-benzodioxepanne-6-carboxamide is useful to treat psychoses.
    Type: Grant
    Filed: August 12, 1986
    Date of Patent: August 9, 1988
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile de France
    Inventors: Denis Besancon, Jacqueline Franceschini
  • Patent number: 4725618
    Abstract: The use of N-(1-allyl-2-pyrrolidinylmethyl) 2-methoxy 4-amino 5-methylsulphamoyl benzamide to treat Parkinson's disease.
    Type: Grant
    Filed: July 15, 1986
    Date of Patent: February 16, 1988
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
    Inventors: Denis Besancon, Brenda Costall, Robert J. Naylor, Peter Jenner, Charles D. Marsden
  • Patent number: 4703055
    Abstract: The invention concerns novel benzamides and their pharmacologically acceptable salts which are useful as gastromotor agents and correspond to the following general formula (I): ##STR1## in which: R.sub.1 is lower alkyl, lower alkenyl or a hydrogen atom;R.sub.2 is alkyl, lower alkenyl, benzyl, cycloalkylalkyl, cycloalkenylalkyl or a hydrogen atom;R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 each are lower alkyl or a hydrogen atom, andX is a halogen atom.
    Type: Grant
    Filed: July 7, 1986
    Date of Patent: October 27, 1987
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
    Inventors: Jacqueline Franceschini, Renee Gardaix-Luthereau, Josette Margarit
  • Patent number: 4673686
    Abstract: There are provided new substituted heterocyclic benzamides and derivatives hereof which provide modifications on the central nervous system.
    Type: Grant
    Filed: August 26, 1985
    Date of Patent: June 16, 1987
    Assignee: Societe d'Etudes Scientifiques et Industrielle de l'Ile de France
    Inventors: Michel Thominet, Jacques Acher, Jean-Claude Monier
  • Patent number: 4661338
    Abstract: A method is provided for rapidly screening candidates for precancerous atrophic H. gastritis by visualizing the presence of a hypoacidity condition of the gastric mucous membrane by applying droplets of an indicator to the stomach wall which indicator undergoes a marked color change in the presence of a hypoacidic condition and then detecting immediately the presence of that color change. The indicator employed is bromocresol green, bromophenol blue or bromochlorophenol blue.
    Type: Grant
    Filed: November 19, 1982
    Date of Patent: April 28, 1987
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile de France
    Inventors: Francois Besancon, Francois Chast
  • Patent number: 4639439
    Abstract: The invention relates to a contraceptive composition of a prolactin elevag benzamide, such as N-[(1-ethyl-2-pyrrolidinyl)methyl]2-methoxy 5-sulfamoyl benzamide, and a progestogen.
    Type: Grant
    Filed: October 10, 1985
    Date of Patent: January 27, 1987
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile de France
    Inventors: Peter W. Howie, Alan McNeilly
  • Patent number: 4607047
    Abstract: N-(1-allyl-2-pyrrolidinylmethyl) 2-methoxy-4-amino-5-methylsulphamoyl benzamide and its pharmacologically acceptable salts thereof are taught to be useful in treating a subject suffering from platelet dysfunction in thrombo-embolic disorders.
    Type: Grant
    Filed: August 7, 1984
    Date of Patent: August 19, 1986
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-De-France
    Inventor: Andre Debay
  • Patent number: 4594428
    Abstract: The present invention concerns compound useful as intermediates in the preparation of heterocyclic phenoxy amines of the formula ##STR1## wherein Y is hydroxyl or chlorine and R is 1-cyclohexenylmethyl.
    Type: Grant
    Filed: January 7, 1983
    Date of Patent: June 10, 1986
    Assignee: Societe d'Etudes Scientifiques et Industrielles de L'ile-de-France
    Inventors: Michel L. Thominet, Jacqueline F. Franceschini
  • Patent number: 4550179
    Abstract: N-(1-allyl-2-pyrrolidinyl-methyl) 2-methoxy-4-amino-5-methylsulfamoyl benide and derivatives thereof, which are useful in the treatment of anomalies in cerebral hemodynamics of patients subject to migraines.
    Type: Grant
    Filed: February 15, 1983
    Date of Patent: October 29, 1985
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de France
    Inventors: Jacques Perrot, Michel Thominet
  • Patent number: 4499019
    Abstract: N-(1'-allyl-2'-pyrrolidylmethyl)-2,3-dimethoxy-5-sulfamoylbenzamide and dvatives thereof and method for treating the psycho neuro-vegetative syndrome of the natural or surgical menopause by administering an effective amount of said compound to a patient.
    Type: Grant
    Filed: October 13, 1983
    Date of Patent: February 12, 1985
    Assignee: Societe D'Etudes Scientifiques et Industrielles de l'Ile de France
    Inventors: Michel L. Thominet, Jacques J. Perrot
  • Patent number: 4405636
    Abstract: N-(1-allyl-2-pyrrolidinyl-methyl)2-methoxy-4-amino-5-methylsulfamoyl benzde and derivatives thereof, which are useful in the treatment of anomalies in cerebral hemodynamics of patients subject to migraines.
    Type: Grant
    Filed: August 25, 1981
    Date of Patent: September 20, 1983
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de France
    Inventors: Jacques Perrot, Michel Thominet
  • Patent number: 4364867
    Abstract: The present invention relates to a novel veratramide, N-(1-methyl-2-pyrroinyl-methyl)-2,3-dimethoxy-5-methylsulphamoyl benzamide, its pharmacologically acceptable acid addition salts, its quaternary ammonium salts, its oxides and its levorotatory and dextrorotatory isomers and their use in the treatment of disorders of the lower urinary apparatus.
    Type: Grant
    Filed: December 11, 1980
    Date of Patent: December 21, 1982
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile de France
    Inventors: Michel Thominet, Jacques Perrot
  • Patent number: 4323503
    Abstract: Novel substituted 2,3-alkylene bis (oxy) benzamides and derivatives thereof are disclosed. Also disclosed is a method for producing said compounds. The compounds have anxiolytic, psychostimulant, disinhibiting and thymoanaleptic properties useful therapeutically in the psychofunctional field, particularly in gastro-enterology, cardiology, urology, rheumatology and gynaecology.
    Type: Grant
    Filed: June 12, 1979
    Date of Patent: April 6, 1982
    Assignee: Societe d'Etudes Scientifiques et Industrielles de L'ile-de-France
    Inventors: Michel Thominet, Gerard Bulteau, Jacques Acher, Claude Collignon
  • Patent number: 4294828
    Abstract: There are provided certain N-(1-lower alkyl-2-pyrrolidylmethyl)2-lower aly-4-amino-5-lower alkyl sulphonyl benzamides and derivatives thereof which provide surprising antiapomorphine and antiserotonin activity.
    Type: Grant
    Filed: January 18, 1979
    Date of Patent: October 13, 1981
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile de-France
    Inventors: Michel Thominet, Jacques Acher, Jean-Claude Monier
  • Patent number: 4268512
    Abstract: Novel substituted 2,3-alkylene bis (oxy) benzamides and derivatives thereof are disclosed. Also disclosed is a method for producing said compounds. The compounds have anxiolytic, psychostimulant, disinhibiting and thymoanaleptic properties useful therapeutically in the psychofunctional field, particularly in gastro-enterology, cardiology, urology, rheumatology and gynaecology.
    Type: Grant
    Filed: February 23, 1979
    Date of Patent: May 19, 1981
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
    Inventors: Michel Thominet, Gerard Bulteau, Jacques Acher, Claude Collignon
  • Patent number: 4263316
    Abstract: The present invention relates to a novel veratramide, N-(1-methyl-2-pyrroinyl-methyl)-2,3-dimethoxy-5-methylsulphamoyl benzamide, its pharmacologically acceptable acid addition salts, its quaternary ammonium salts, its oxides and its levorotatory and dextrorotatory isomers and their use in the treatment of disorders of the lower urinary apparatus.
    Type: Grant
    Filed: October 5, 1979
    Date of Patent: April 21, 1981
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile de France
    Inventors: Michel Thominet, Jacques Perrot
  • Patent number: 4248885
    Abstract: Novel substituted 2,3-alkylene bis (oxy) benzamides and derivatives thereof are disclosed. Also disclosed is a method for producing said compounds. The compounds have anxiolytic, psychostimulant, disinhibiting and thymoanaleptic properties useful therapeutically in the psychofunctional field, particularly in gastro-enterology, cardiology, urology, rheumatology and gynaecology.
    Type: Grant
    Filed: February 23, 1979
    Date of Patent: February 3, 1981
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
    Inventors: Michel Thominet, Gerard Bulteau, Jacques Acher, Claude Collignon
  • Patent number: 4186135
    Abstract: Novel substituted 2,3-alkylene bis (oxy) benzamides and derivatives thereof are disclosed. Also disclosed is a method for producing said compounds. The compounds have anxiolytic, psychostimulant, disinhibiting and thymoanaleptic properties useful therapeutically in the psychofunctional field, particularly in gastro-enterology, cardiology, urology, rheumatology and gynaecology.
    Type: Grant
    Filed: August 2, 1977
    Date of Patent: January 29, 1980
    Assignee: Societe D'Etudes Scientifiques et Industrielles de L'ile-de-France
    Inventors: Michel Thominet, Gerard Bulteau, Jacques Acher, Claude Collignon