Abstract: The invention relates to a syringe-type device for freshly preparing a solution, suspension or dispersion, for example injectable formulations, preferably according to a method for reconstitution in a vacuum. The device is shown in FIG. 1. The invention also relates to a method for packing the fresh preparation of the solution, suspension or dispersion in a cylindrical reservoir that can be used in a single or multi-dose syringe provided for the same. This is a method for packing the preparation inside the cylindrical reservoir, which is closed on one side by an injection plunger whose movement in the reservoir is limited. This method is characterised in that the elements to be packed are introduced into the reservoir from the injection plunger side before the reservoir is closed by said plunger. Said reservoir is a tube or ampule which is closed on the other side in advance.
Type:
Grant
Filed:
October 10, 2000
Date of Patent:
June 7, 2005
Assignee:
Societe de Conseils de Recherches et Applications Scientifiques (S.C.R.A.S.)
Inventors:
Roland Cherif-Cheikh, Christophe Aubert
Abstract: A process for the preparation of a compound of the formula
wherein the substituents are defined as set forth in the specification comprising reacting a compound of the formula
with a 2-halo-3-quinoline-methanol of the formula
to obtain a compound of the formula
which is then cyclized to form the compound of Formula I.
Type:
Grant
Filed:
January 30, 2002
Date of Patent:
July 13, 2004
Assignee:
Societe de Conseils de Recherches et Applications
Scientifiques (S.C.R.A.S.)
Inventors:
Dennis Bigg, Olivier Lavergne, Francesc Pla Rodas, Jacques Pommier, Gerard Ulibarri, Jerry Harnett, Alain Rolland, Anne-Marie Liberatore, Christophe Lanco, Jean-Bernard Cazaux, Christine Le Breton, Eric Manginot