Abstract: Thiaxozle, oxazole, imidazole, isoxazole and isoxazoline compounds of the formula wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is selected from the various optionally substituted aromatic radicals defined in the specification, B is hydrogen, alkyl or phenyl, R1 and R2 are independently hydrogen, alkyl or cycloalkyl or R1 and R2 taken together with the carbon atom which carries them, form a carbocycle with 3 to 7 members and ? is —NH46R47 or —OR48, R46 and R47 are independently hydrogen, alkyl, cycloalkyl or —(CH2)kCOOR51, R51 is alkyl or haloalkyl and R48 is hydrogen or alkyl having advantageous pharmacological properties which allow their use in therapeutics, for treating neurodegenerative disorders or pain.
Type:
Grant
Filed:
August 10, 2004
Date of Patent:
November 6, 2007
Assignee:
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Inventors:
Pierre-Etienne Chabrier De Lassauniere, Jermiah Harnett, Dennis Bigg, Ann-Marie Liberatore, Jacques Pommier, Jacques Lannoy, Christophe Thurieau, Zheng Xin Dong
Abstract: Heterocyclic dione compounds as disclosed in the specification, compositions thereof and methods for the use thereof, for the treatment of T cell-mediated conditions such as autoimmune diseases and organ graft rejection.
Type:
Application
Filed:
May 22, 2007
Publication date:
November 1, 2007
Applicant:
Societe de Conseils de Recherches et D'Application Scientifiques (S.C.R.A.S.)
Abstract: The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefore comprising said analogues.
Type:
Application
Filed:
December 29, 2006
Publication date:
October 18, 2007
Applicant:
SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES, S.A.S.
Inventors:
Zheng Dong, Resurreccion Miravete, Roland Cherif-Cheikh, Jose-Antonio Rigol, Frederic Lacombe, Maria Maestre
Abstract: The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S.
Type:
Grant
Filed:
December 24, 2002
Date of Patent:
October 9, 2007
Assignee:
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Abstract: The present invention relates to a method of treating insulin resistance or Syndrome X by administering a therapeutically effective amount of a somatostatin agonist or a pharmaceutical composition comprised of a somatostatin agonist to a patient suffering from insulin resistance or Syndrome X.
Type:
Grant
Filed:
February 18, 2003
Date of Patent:
August 14, 2007
Assignee:
Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
Inventors:
Michael Anthony Cawthorne, Yong-Ling Liu, Matthew V. Sennitt
Abstract: The invention concerns a pharmaceutical composition comprising, as active principle, at least a calpain inhibiting substance and at least a substance trapping reactive oxygen species (ROS), and optionally an acceptable pharmaceutical carrier. The invention also concerns a product comprising at least a calpain inhibiting substance and at least a substance trapping reactive oxygen species (ROS), selectively or not, as combination product, the active principle being separate.
Type:
Grant
Filed:
November 14, 2001
Date of Patent:
July 17, 2007
Assignee:
Societe de Conseils de Recherches et d' 'Applications Scientifiques S.C.R.A.S
Inventors:
Pierre-Etienne Chabrier de Lassauniere, Bernadette Pignol, Serge Auvin
Abstract: The present invention relates to a method of inhibiting fibrosis in a patient. The method comprises administering a therapeutically effective amount of a somatostatin, a somatostatin agonist or apharmaceutically acceptable salt thereof to said patent.
Type:
Grant
Filed:
September 7, 2004
Date of Patent:
July 3, 2007
Assignee:
Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S
Abstract: The invention concerns a novel protein modulating cancer cell proliferation. The proteins encoded by the polynucleotides of the invention enable to determine the degree of malignity of abnormal cell proliferation.
Type:
Grant
Filed:
March 1, 2002
Date of Patent:
May 8, 2007
Assignees:
Societe de Conseils de Recherches Et d'Applications Scientifiques (S.C.R.A.S.), Centre National de la Rescherche Scientifique (C.N.R.S.)
Inventors:
Eric Ferrandis, José-Antonio Camara Y Ferrer, Jean Martinez, Christophe Thurieau
Abstract: Compounds of the formula in racemic or enantiomeric forms wherein the substituents are as defined in the application. Useful for treating acromegalia, hypophyseal adenomas or endocrinic gastroenteropancreatic tumors.
Type:
Grant
Filed:
March 30, 2004
Date of Patent:
April 3, 2007
Assignee:
Societe de Conseils de Recherches et d' 'Applications Scientifiques (S.C.R.A.S)
Abstract: The invention concerns novel cdc25 phosphatase inhibitors, and in particular cdc25-C, which correspond to the general formula (I) wherein: A represents a carbocyclic aryl radical optionally substituted 1 to 3 times by one or more radicals independently selected among a halogen atom and an alkyl, hydroxy, alkoxy, alkylthio or NR1R2 radical wherein R1 and R2 represent a hydrogen atom or an alkyl radical or R1 and R2 form together with the nitrogen atom a heterocycle of 4 to 7 members comprising 1 to 2 heteroatoms, the members required to complete the heterocycle being selected independently among the CR3R4—, —O—, —S and NR5-radicals, R3 and R4 representing independently each time they are involved a hydrogen atom or an alkyl, hydroxy, alkoxy, amino, alkylamino or dialkylamino radical, and R5 representing independently each time it is involved a hydrogen atom or an alkyl radical, or A represents a phenyl radical substituted by a phenyl radical optionally substituted 1 to 3 times by one or more radicals selected
Type:
Grant
Filed:
July 26, 2001
Date of Patent:
March 27, 2007
Assignee:
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Abstract: Novel imidazole compounds of the formula wherein the substituents are as defined in the application having antitumoral activity and use thereof.
Type:
Application
Filed:
May 26, 2004
Publication date:
March 22, 2007
Applicant:
SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATION SCIENTIFIQUES (S.C.R.A.S.)
Inventors:
Dennis Bigg, Anne-Marie Liberatore, Dominique Pons
Abstract: The invention concerns the use of zinc derivatives of general formula (I) wherein: L1 represents a group of formula: —E14(R14)(R?14)(R?14), —E15(R15) (R?15) or —E16(R16); E is an atom of group 15; L2 and L3 independently represent a group of formula: —E14(R14)(R?14)(R?14), —E15(R15)(R?15) or —E16(R16), or together form a chain of formula —L?2—A—L?3—; A represents a saturated or unsaturated chain comprising one, two or three elements of group 14; L?2 and L?3 independently represent a group of formula —E14(R14)(R?14) —E15(R15) or —E16—; E14 is an element of group 14; E15 is an element of group 15; E16 is an element of group 16; R14, R?14, R?14, R15, R?15 and R16 represent various groups, as (co) polymerisation catalysts of cyclic esters
Type:
Grant
Filed:
April 9, 2002
Date of Patent:
January 30, 2007
Assignees:
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.), Centre National de la Recherche Scientifique (C.N.R.S.)
Inventors:
Anca Dumitrescu, Martin-Vaca Blanca, Heinz Gornitzka, Didier Bourissou, Jean-Bernard Cazaux, Guy Bertrand
Abstract: A method of modulating, sodium channels in warm-blooded animals in need thereof by administering a compound of the formula Wherein the substituents are defined as in the specification and compounds of the formula wherein the substituents are as defined in the specification.
Type:
Grant
Filed:
June 14, 2002
Date of Patent:
January 2, 2007
Assignee:
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Inventors:
Dennis Bigg, Jacques Pommier, Anne-Marie Liberatore
Abstract: A method of treating pain in a warm-blooded animal comprising administering to anwarm-blooded animal in need thereof an amount of a compound of the formula wherein the substituents are defined in accordance with the disclosure.
Type:
Grant
Filed:
July 26, 2004
Date of Patent:
October 17, 2006
Assignee:
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Inventors:
Pierre Etienne Chabrier de Lassauniere, Serge Auvin, Dennis Bigg, Michel Auquet, Jeremiah Harnett
Abstract: A subject of the present invention is new compounds having a lanthanide and having a tridentate ligand, a process for their preparation and their use in particular as polymerization catalysts.
Type:
Grant
Filed:
January 20, 2004
Date of Patent:
September 5, 2006
Assignees:
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.), Centre National de la Recherche Scientifique (C.N.R.S.)
Inventors:
Anca Dumitrescu, Heinz Gornitzka, Blanca Martin-Vaca, Didier Bourissou, Guy Bertrand, Jean-Bernard Cazaux
Abstract: The invention relates to a method for preparing polyesters A containing several mid-chain free acid functions by ring-opening polymerisation in the presence of a chain initiator: the benzyl diester of the tartaric acid, the phenyl radical of which is optionally substituted. A: aliphatic based on cyclic esters such as lactides and glycolides.
Type:
Grant
Filed:
February 22, 2002
Date of Patent:
August 22, 2006
Assignee:
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Inventors:
Jean-Bernard Cazaux, Charles Brigati, Alexandre Louchkoff, Francis Diancourt
Abstract: A method of treating proliferative diseases in warm-blooded animals comprising administering to warm-blooded animals in need thereof an amount of at least one compound selected from the group consisting of mikanolide and dihydromikanolide sufficient to treat said disease.
Type:
Grant
Filed:
June 9, 2004
Date of Patent:
August 15, 2006
Assignee:
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Abstract: The use of stannylenes and germylenes of general formula (I) wherein: M represents a tin or geranium atom; L1 and L2 independently represent a group of formula: -E14(R14) (R?14) (R?14), -E15(R15) (R?15) or -E16(R16)) or together form a chain of formula -L?1-A- L?2; A represents a saturated or unsaturated chain comprising one, two or three elements of group 14; L?1 and L?2, represent, independently, a group of formula: -E14(R14) (R?14)-, E15(R15)- or -E16-; E14 is an element of group 14; E15 is an element of group 15; E16 is an element of group 16; R14, R?14, R?14, R15, R?15 and R16 represent variable groups as polymerization catalysts of heterocycles.
Type:
Grant
Filed:
May 10, 2001
Date of Patent:
August 1, 2006
Assignees:
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.), Centre National de la Recherche Scientifique
Inventors:
Anca Dumitrescu, Heinz Gornitzka, Blanca Martin-Vaca, Didier Bourissou, Guy Bertrand, Jean-Bernard Cazaux