Patents Assigned to Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
  • Use of a flavonoid extract of ginkgo biloba substantially devoid of terpenes, in the dentibuccal field, and composition containing such extract
    Patent number: 6340456
    Abstract: The invention concerns the use of a flavoniodic extract of ginkgo biloba leaves, and more specifically an extract devoid of terpenes for oral hygiene. The invention also concerns a composition for oral hygiene containing such an extract.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: January 22, 2002
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventor: Joseph O'Reilly
  • New derivatives of 2-(iminomethyl) amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
    Publication number: 20020007062
    Abstract: A method for treating neurodegenerative diseases in a warm-blooded animal comprising administering to a warm-blooded animal in need thereof an amount of a compound of the formula 1
    Type: Application
    Filed: June 15, 2001
    Publication date: January 17, 2002
    Applicant: SOCIETE DE CONSEILS DE RECHERCHES ET D' APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)
    Inventors: Pierre Etienne Chabrier de Lassauniere, Serge Auvin, Dennis Bigg, Michel Auguet, Jeremiah Harnett
  • Comptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues
    Patent number: 6339091
    Abstract: The compound of the formula wherein the substituents are defined as in the specification and its non-toxic, pharmaceutically acceptable salts which are useful for the treatment of viral infections, parasitic diseases and the treatment of cancer.
    Type: Grant
    Filed: June 14, 1999
    Date of Patent: January 15, 2002
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Dennis Bigg, Olivier Lavergne, Francesc Pla Rodas, Jacques Pommier, Gerard Ulibarri, Jerry Harnett, Alain Rolland, Anne-Marie Liberatore, Christophe Lanco, Jean-Bernard Cazaux, Christine Le Breton, Eric Manginot
  • Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
    Patent number: 6335445
    Abstract: A compound selected from the group consisting of a compound of the formula wherein A is selected from the group consisting of and the other substituents are defined in the specification having an inhibitory activity of NO-synthase enzymes producing nitrogen mono-oxide and/or an activity which traps the reactive oxygen species.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: January 1, 2002
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Pierre Etienne Chabrier de Lassauniere, Serge Auvin, Dennis Bigg, Michel Auguet, Jeremiah Harnett
  • Therapeutic use of a thienylcyclohexylamine derivative
    Publication number: 20010056091
    Abstract: A method of inhibiting effects of exogenous neurotoxic or neurotoxinic products in warm-blooded animals comprising administering to warm-blooded animals before exposure to said products an inhibitorily effective amount of reversible cholinesterase inhibitor selected from the group consisting of pyridostigmine and physostigmine followed by administration of an inhibitorily effective amount of 2-methyl-1-(1-piperidinyl)-1-(2-thienyl)-cyclohexane in substantially pure racemic, diastereoisomeric or enantiomeric form.
    Type: Application
    Filed: April 13, 2001
    Publication date: December 27, 2001
    Applicant: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S)
    Inventors: Guy Lallement, Pierre D'Arbigny, Jean-Marc Kamenka
  • Ginkgo biloba flavonoid extract free of terpene and/or with a high flavonoid heteroside content
    Publication number: 20010043976
    Abstract: A process for preparing a flavonoid extract from the leaves of ginkgo biloba comprising multiple distractions of the leaves of the ginkgo biloba with solvents wherein at least one of the extraction stages is a deterpenation step using a solvent of the formula RC(O)OR′ wherein R and R′ are individually lower alkyl.
    Type: Application
    Filed: April 18, 2001
    Publication date: November 22, 2001
    Applicant: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)
    Inventor: Joseph O'Reilly
  • Analogues of camptothecin, preparation procedures, their application as medicines and the pharmaceutical compositions comprising them
    Patent number: 6313135
    Abstract: A compound of the formula wherein the substituents are as defined in the specification and a method of inhibiting tumors.
    Type: Grant
    Filed: June 4, 1999
    Date of Patent: November 6, 2001
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Dennis Bigg, Olivier Lavergne, Francesc Pla Rodas, Jacques Pommier, Gerard Ulibarri
  • Metal complexes with a tridentate ligand as polymerization catalysts
    Patent number: 6303807
    Abstract: The invention concerns novel compounds having the elements of group 11, 12 or 14; and a tridentate ligand, a method for preparing them and their use in particular as polymerisation catalyst.
    Type: Grant
    Filed: December 23, 1999
    Date of Patent: October 16, 2001
    Assignees: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.), Centre National de la Recherche Scientifique (C.N.R.S.)
    Inventors: Guy Bertrand, Jean-Bernard Cazaux, Jean-Luc Faure, Hanh Nguyen, Régis Reau
  • &agr;1-adrenergic receptor antagonists
    Patent number: 6300499
    Abstract: Phenylpiperazine derivatives having high affinity for the &agr;1-adrenoreceptor and pharmaceutical compositions containing them. Also disclosed is a method of using the such derivatives to treat benign prostatic hyperplasia.
    Type: Grant
    Filed: September 28, 1998
    Date of Patent: October 9, 2001
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Dennis Bigg, Pierre Etienne Chabrier de Lassauniere, Serge Auvin, Michel Auguet
  • Association of no syntase inhibitors with trappers of oxygen reactive forms
    Patent number: 6297281
    Abstract: The invention concerns a pharmaceutical composition containing, as active principle, at least one NO syntase inhibiting substance and at least one oxygen reactive form trapping substance, optionally with a pharmaceutically acceptable support. The invention also concerns a product containing at least one NO syntase inhibiting substance and at least one oxygen reactive form trapping substance as combined product of these active principles in separate form.
    Type: Grant
    Filed: March 2, 1999
    Date of Patent: October 2, 2001
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Pierre-Etienne Chabrier de Lassauniere, Dennis Bigg
  • Compounds having one group 13 element, bound with one mono- or di-anionic trident ligand, a method of preparation and application thereof as polymerization catalysts
    Patent number: 6281154
    Abstract: Novel compounds having one group 13 element bound with one mono- or di-anionic tridentate ligand, a method of preparation thereof and use thereof as a copolymerization catalyst.
    Type: Grant
    Filed: October 28, 1998
    Date of Patent: August 28, 2001
    Assignees: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S), Centre National de la Recherche Scientifique (CNRS)
    Inventors: Guy Bertrand, Jean Bernard Cazaux, Norbert Emig, Régis Reau
  • Ginkgo Bilboa flavonoid extract which is terpene-free and has a high flavonoid heteroside content
    Patent number: 6242030
    Abstract: The invention concerns a Ginkgo biloba leaf flavonoid extract and more specifically an extract which is terpene free and/or has a high flavonoid heteroside content. The invention also concerns a flavoring compound containing such an extract and the use of this extract as a flavoring ingredient. The invention finally concerns a process for obtaining a substantially terpene-free Ginkgo biloba leaf flavonoid extract.
    Type: Grant
    Filed: November 5, 1997
    Date of Patent: June 5, 2001
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventor: Joseph O'Reilly
  • Polycarboxylic based cross-linked copolymers
    Patent number: 6229009
    Abstract: A cross-linked copolymer based on at least one non-crosslinked polycarboxylic polysaccharide and at least one second non-crosslinked polycarboxylic polymer which is not a polycarboxylic polysaccharide and a cross-linking agent having at least two amine functions.
    Type: Grant
    Filed: February 18, 1999
    Date of Patent: May 8, 2001
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Nada Lambert, Denis Labarre, Hatem Fessi
  • Therapeutic application of a thienycyclohexylamine derivative
    Patent number: 6207685
    Abstract: A method of inhibiting effects of neurotoxic products in warm-blooded animals comprising administering to warm-blooded animals an amount of 2-methyl-1-(1-piperidinyl)-1-(2-thienyl)-cyclohexane in substantially pure racemic, diastereoisomeric or enantiomeric form effect to inhibit effects of neurotropic products and mixtures of thienyl cyclohexylamine and at least one member of the group consisting of anticholinergic, anticonvulsant or cholinesterase-reactivating substances.
    Type: Grant
    Filed: January 11, 1999
    Date of Patent: March 27, 2001
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Guy Lallement, Pierre D'Arbigny, Jean-Marc Kamenka
  • Use of Ginkgo biloba flavonoidic extract substantially devoid of terpenes for oral hygiene and composition containing such extract
    Patent number: 6159450
    Abstract: The invention concerns the use of a flavonoidic extract of ginkgo biloba leaves, and more specifically an extract designed for oral hygiene. The invention also concerns a composition for oral hygiene containing such an extract.
    Type: Grant
    Filed: April 6, 1999
    Date of Patent: December 12, 2000
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques S.C.R.A.S.
    Inventor: Joseph O'Reilly
  • Glycosylated ginkgolide derivatives, their application as medicines and pharmaceutical compositions
    Patent number: 6143725
    Abstract: The invention relates to new glycosylated derivatives of ginkgolides, their use as medicaments and the pharmaceutical compositions containing them. The invention also provides a preparation process for these derivatives.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: November 7, 2000
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S)
    Inventors: Andrea Vasella, Martin Weber
  • Heteroaryloxyethylamines, method of preparation, application as medicine and pharmaceutical compositions containing them
    Patent number: 6063784
    Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as in the application and its non-toxic, pharmaceutically acceptable acid addition salts which are useful for treating hypertension.
    Type: Grant
    Filed: March 10, 1999
    Date of Patent: May 16, 2000
    Assignee: Societe de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S. )
    Inventors: Dennis Bigg, Marie-Odile Galcera
  • Camptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues
    Patent number: 5981542
    Abstract: A camptothecin analog characterized in that the hydroxy lactone of the camptothecin is a .beta.-hydroxy lactone or the corresponding .beta.-hydroxyacid, resulting from the opening of said lactone, or a derivative of said .beta.-hydroxyacid, or a Pharmaceutically acceptable salt thereof, is disclosed. In particular, compounds of formulae (I) and (II) are disclosed. Methods for preparing the compounds of formulae (I) and (II), pharmaceutical compositions containing said containing said compounds, and their use, particularly as topoisomerase inhibitors and antitumoral drugs, are also disclosed.
    Type: Grant
    Filed: December 2, 1997
    Date of Patent: November 9, 1999
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Dennis Bigg, Olivier Lavergne, Francesc Pla Rodas, Jacques Pommier, Gerard Ulibarri
  • Antisense oligonucleotides for inhibiting helicobacter pylori activity
    Patent number: 5977340
    Abstract: Antisense oligonucleotides that selectively hybridise with one or more genes necessary for Helicobacter pylori (H. pylori) activity, and particularly with the CagA cytotoxicity-associated immunodominant antigen, flagellin (flaA and flaB) or vacuolating cytotoxin (vacA), are disclosed. Pharmaceutical compositions containing said antisense oligonucleotides, and the use thereof for treating atrophic gastritis, peptic and duodenal ulcers, gastric atrophy or stomach cancer, are also disclosed.
    Type: Grant
    Filed: October 1, 1997
    Date of Patent: November 2, 1999
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Eduardo Pirotzky, Soudhir Colote
  • Galanthamine derivatives, and their pharmaceutical compositions
    Patent number: 5958903
    Abstract: Novel galanthamine derivatives of general fonnulae (Ia) and (Ib), a method for preparing same, pharmaceutical compositions containing said derivatives, and their use, in particular as cholinesterase inhibitors, are disclosed.
    Type: Grant
    Filed: January 9, 1998
    Date of Patent: September 28, 1999
    Assignee: Societe de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Dolor Renko, Pierre Potier, Yves Christen, Claude Thal, Catherine Guillou, Aude Mary