Patents Assigned to Societe de Conseils de Recherches et d'Applications Scientifiques, S. A. S.
  • Somatostatin-dopamine chimeric analogs
    Patent number: 7579435
    Abstract: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: 6-n-propyl-8?-ergolinglmethylthioacetyl-D-Phe-c-(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH2.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: August 25, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Michael D. Culler, Zheng Xin Dong, Sun H. Kim, Jacques-Pierre Moreau
  • Somatostatin-dopamine chimeric analogs
    Patent number: 7572883
    Abstract: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo.
    Type: Grant
    Filed: May 15, 2006
    Date of Patent: August 11, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Michael D. Culler, Zheng Xin Dong, Sun H. Kim, Jacques-Pierre Moreau
  • Imidazolyl derivatives
    Patent number: 7566734
    Abstract: The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin receptors.
    Type: Grant
    Filed: July 31, 2001
    Date of Patent: July 28, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Christophe Alain Thurieau, Lydie Francine Poitout, Marie-Odile Galcera, Thomas D. Gordon, Barry A. Morgan, Christophe Philippe Moinet, Dennis C. H. Bigg
  • PTH2 receptor selective compounds
    Patent number: 7531621
    Abstract: This invention relates to a series of PTH and PTHrP analogues that selectively bind to PTH2 receptors and as such may be useful in treating abnormal CNS functions; abnormal pancreatic functions; divergence from normal mineral metabolism and homeostasis; male infertility; regulation of abnormal blood pressure; and hypothalmic disease.
    Type: Grant
    Filed: May 3, 1999
    Date of Patent: May 12, 2009
    Assignees: Societe de Conseils de Recherches et d'Applications Scientifiques S.A.S., Beth Israel
    Inventors: Zheng Xin Dong, Michael Chorev, Michael Rosenblatt
  • GLP-1 pharmaceutical compositions
    Patent number: 7521527
    Abstract: The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: April 21, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Zheng Xin Dong, Roland Cherif-Cheikh
  • Safety injection device for a liquid or semi-solid composition
    Patent number: 7445612
    Abstract: The invention features a safety injection device for injecting a liquid or semi-solid composition into a subject.
    Type: Grant
    Filed: April 10, 2001
    Date of Patent: November 4, 2008
    Assignee: Société de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventor: Roland Cherif-Cheikh
  • Prenyl transferase inhibitors
    Patent number: 7361656
    Abstract: A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by the following formula: wherein X is (CHR11)n3(CH2)n4Z(CH2)n5 where Z is O, N(R12), S, or a bond; Y is CO, CH2, CS, or a bond; R1 is or N(R24R25); and the remaining substituents are as defined in the disclosure.
    Type: Grant
    Filed: February 14, 2006
    Date of Patent: April 22, 2008
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Thomas D. Gordon, Barry A. Morgan
  • Farnesyl transferase inhibitors
    Patent number: 7323484
    Abstract: The present invention is directed to compounds of the formula wherein the variables are as defined in the specification. The compounds are useful for inhibiting farnesyl transferase and for the treatment of tumors and restenosis.
    Type: Grant
    Filed: November 28, 2005
    Date of Patent: January 29, 2008
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Thomas D. Gordon, Barry A. Morgan
  • GLP-1 pharmaceutical compositions
    Publication number: 20070244034
    Abstract: The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefore comprising said analogues.
    Type: Application
    Filed: December 29, 2006
    Publication date: October 18, 2007
    Applicant: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES, S.A.S.
    Inventors: Zheng Dong, Resurreccion Miravete, Roland Cherif-Cheikh, Jose-Antonio Rigol, Frederic Lacombe, Maria Maestre
  • Somatostatin and somatostatin agonists for treating insulin insensitivity and Syndrome X
    Patent number: 7256174
    Abstract: The present invention relates to a method of treating insulin resistance or Syndrome X by administering a therapeutically effective amount of a somatostatin agonist or a pharmaceutical composition comprised of a somatostatin agonist to a patient suffering from insulin resistance or Syndrome X.
    Type: Grant
    Filed: February 18, 2003
    Date of Patent: August 14, 2007
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Michael Anthony Cawthorne, Yong-Ling Liu, Matthew V. Sennitt
  • Method of inhibiting fibrosis with a somatostatin agonist
    Patent number: 7238666
    Abstract: The present invention relates to a method of inhibiting fibrosis in a patient. The method comprises administering a therapeutically effective amount of a somatostatin, a somatostatin agonist or apharmaceutically acceptable salt thereof to said patent.
    Type: Grant
    Filed: September 7, 2004
    Date of Patent: July 3, 2007
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S
    Inventors: Michael D. Culler, Philip G. Kasprzyk
  • Farnesyl transferase inhibitors
    Patent number: 7022704
    Abstract: A family of tetrahydroimidazo[1,2a]pyrazine based compounds capable of inhibiting the activity of farnesyl transferase and treating tumors and restenosis having the following structure: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined in the specification.
    Type: Grant
    Filed: October 18, 2002
    Date of Patent: April 4, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Thomas D. Gordon, Barry A. Morgan
  • Analogs of parathyroid hormone
    Patent number: 6921750
    Abstract: The present invention is directed to peptide analogues of fragment of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP), a method of using said analogues alone or in combination with a bisphosphonate or calcitonin to treat osteoporosis and pharmaceutical compositions comprising said analogues alone or in combination with a bisphosphonate or calcitonin.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: July 26, 2005
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventor: Zheng Xin Dong
  • Analogues of GLP-1
    Patent number: 6903186
    Abstract: The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: June 7, 2005
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S
    Inventor: Zheng Xin Dong
  • Neuromedin b and somatostatin receptor agonists
    Patent number: 6903074
    Abstract: A novel class of analogs which exhibit both high affinity and selectivity for Neuromedin B and Somatostann receptors are claimed. One example is Nal-Tyr-cyclo(D-Cys-D-Trp-Lys-D-Cys)-Abu-Nal-NH2.
    Type: Grant
    Filed: June 5, 2000
    Date of Patent: June 7, 2005
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Barry A. Morgan, Dean Sadat-Aalaee
  • Safety injection device
    Patent number: 6896670
    Abstract: An injection device for intramuscular or subcutaneous injection of solid or semi-solid medicaments is disclosed. The device includes main body member having a needle attached thereto. A protective sleeve covers the needle and retracts into the main body member when the device is pressed against the skin of a patient. A plunger with an attached rod maintains the medicament in the patient as the needle is withdrawn.
    Type: Grant
    Filed: September 26, 2002
    Date of Patent: May 24, 2005
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventor: Roland Cherif Cheikh
  • Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
    Patent number: 6867181
    Abstract: A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing polymer and a free amino group-containing drug which are ionically bonded to each other.
    Type: Grant
    Filed: January 26, 2000
    Date of Patent: March 15, 2005
    Assignees: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S., Poly-Med, Incorporated
    Inventors: Shalaby Wahba Shalaby, Steven A. Jackson, Jacques-Pierre Moreau
  • Somatostatin agonists
    Patent number: 6864234
    Abstract: The present invention is directed to cyclic peptides of formula (I): X-A1-cyclo(D-Cys-A3-A4-Lys-A6-A7)-A8-Y, or a pharmaceutically acceptable salt thereof. The peptides bind selectively to the somatostatin subtype receptor type-5 and elicit an agonist effect from the somatostatin subtype receptors.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: March 8, 2005
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Dean Sadat-Aalaee, Barry A. Morgan
  • Imidazolyl derivatives
    Patent number: 6852725
    Abstract: The present invention is directed to imidazolyl derivatives of the formula: where the substituents are defined in the specification, or a pharmaceutically acceptable salt thereof. The derivatives bind selectively to the somatostatin subtype receptors and elicit either an agonist or antagonist effect from the somatostatin subtype receptors.
    Type: Grant
    Filed: June 8, 1999
    Date of Patent: February 8, 2005
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S. A. S.
    Inventors: Christophe Alain Thurieau, Lydie Francine Poitout, Marie-Odile Galcera, Christophe Philippe Moinet, Thomas D. Gordon, Barry A. Morgan
  • Analogs of parathyroid hormone
    Patent number: RE40850
    Abstract: The present invention is directed to peptide analogues of fragment of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP), a method of using said analogues alone or in combination with a bisphosphonate or calcitonin to treat osteoporosis and pharmaceutical compositions comprising said analogues alone or in combination with a bisphosphonate or calcitonin.
    Type: Grant
    Filed: September 19, 2006
    Date of Patent: July 14, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventor: Zheng Xin Dong