Abstract: The invention concerns a device for injecting a solid medicine (10) comprising a body (2) inside which moves along a general forward moving axis (X-X) a bevelled (34) needle (4) wherein is introduced the medicine (10), said injection device (1) further comprising retaining means for preventing the medicine from falling (10) prior to being injected. The invention is characterized in that the medicine (10) is retained through an elastic deformation imparted to the needle (4) by the retaining means or by an elastic deformation of the retaining means themselves, or still by the combined flexibility of those two means.
Type:
Grant
Filed:
November 15, 2005
Date of Patent:
January 8, 2013
Assignee:
Société de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S) SAS
Abstract: The present invention relates to new derivatives of imidazo, pyrimido and diazepine-pyrimidine-dione of the general formula (I) in which R1, R2, L1, L2, Y, Z and A are various and varying groups. These products exhibit a good affinity for certain sub-types of cannabinoid receptors, in particular the CB2 receptors. They are particularly useful for treating pathological conditions and diseases in which one or more cannabinoid receptors are involved. The invention also relates to pharmaceutical compositions containing said products, and to the use thereof for preparing a drug.
Type:
Application
Filed:
December 17, 2007
Publication date:
June 10, 2010
Applicant:
SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)
Abstract: The invention concerns a novel method for synthesis of 1,4-morpholine-2,5-diones of formula (I), wherein: R, R1, R2, R3 and R4 independently represent various radicals, by oxidizing the ketone function of a cyclic compound of formula (II).
Type:
Application
Filed:
January 24, 2007
Publication date:
February 11, 2010
Applicant:
Societe de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
Inventors:
Didier Bourissou, Blaca Martin-Vaca, Sylvie Moebs-Sanchez, Coralie Ivens, Roland Cherif-cheikh, Anne-Paula De Sousa Delgado
Abstract: A process for preparing recombinant heterocarpine with the complete sequence of heterocarpine (SEQ. ID. NO. 10), expression vectors comprising a polynucleotide encoding for heterocarpine, host cells transformed or transfected by said expression vectors as well as a process for obtaining heterocarpine by means of said transformed or transfected host cells are described where in the recombinant heterocarpine obtained is used to treat cancer.
Type:
Grant
Filed:
December 9, 2003
Date of Patent:
February 2, 2010
Assignee:
Societe de Conseils de Recherches et d'Application Scientifiques (S.C.R.A.S.)
Abstract: A subject of the present invention is novel compounds comprising 2 or 3 benzothiazole-4,7-dione- or benzooxazole-4,7-dione-type units, which inhibit the cdc25 phosphatases, in particular cdc25-C phosphatase. These compounds can in particular be used in the treatment of cancer.
Type:
Application
Filed:
December 16, 2005
Publication date:
November 5, 2009
Applicant:
Societe de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
Inventors:
Marie-Odile Galcera-Contour, Dennis Bigg, Grégoire Prevost, Alban Sidhu
Abstract: The invention relates to a product comprising (1R)-1-[(({2R)-2-amino-3-[(8S)-8-(cyclohexylmethyl) -2-phenyl-5,6-dihydroimidazo [1,2-a]pyrazin-7(8H)-yl]-3-oxopropyl}dithio)methyl]-2-[(8S)-8-(cyclohexylmethyl) -2-phenyl-5,6-dihydrolmidazo[1,2-a]pyrazin-7(8H)-yl]-2-oxoethylamine in association with an analgesic agent selected from morphine, the similar or a morphine derivative, sodium channel inhibitors, non-steroidal antiflammatory agents (AINS), glutamatergic system inhibitors, tricycle antidepressants and gabaergic derivatives for simultaneous therapeutic use which is separated or out over the time for pain treatment or prevention.
Type:
Application
Filed:
December 16, 2005
Publication date:
October 29, 2009
Applicant:
Societe de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
Inventors:
Michel Auguet, Christine Favre, Gregoire Prevost, Pierre-Etienne Chabrier De Lassauniere
Abstract: The invention relates to a device which is used to inject an implant (6) into tissues (50). The inventive device is characterized in that it comprises : a main hollow body (2; 2?) having a hollow needle (4; 4?) fixed thereto, into which the implant (6) is introduced; a secondary body (26; 26?) which is disposed coaxially inside the main body (2; 2?) and which surrounds the needle (4; 4?); and a plunger rod (36; 36?) which can slide coaxially inside the hollow needle (4; 4?).
Type:
Application
Filed:
November 15, 2005
Publication date:
August 20, 2009
Applicant:
Société de Conseils de Recherches et d'Application Scientifiques (S.C.R.A.S.) SAS
Abstract: The invention concerns the use or a fragment of botulinum toxin having said toxin activity for preparing a medicine for reversibly desensitizing an area of the skin, said skin area being designed to receive injections. Said injections can be related, for example, to repeated delivery of insulin, growth hormones or other medicines in injectable form.
Type:
Application
Filed:
December 21, 2005
Publication date:
July 23, 2009
Applicant:
Societe de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
Abstract: The invention concerns novel imidazole derivatives of general formula (I), wherein Z? and Z represent different variable groups. Said products have an antitumoral activity. The invention also concerns pharmaceutical compositions containing said products and their use for preparing antitumoral medicine.
Type:
Application
Filed:
April 26, 2007
Publication date:
July 23, 2009
Applicant:
Societe de Conseils de Recherches et D' Applications Scientifiques (S.C.R.A.S.)
Inventors:
Anne-Marie Liberatore, Dennis Bigg, Dominique Pons, Grégoire Prevost
Abstract: A subject of the invention is a product comprising at least one Cdc25 phosphatase inhibitor in combination with at least one other anti-cancer agent for a therapeutic use which is simultaneous, separate or spread over time in the treatment of cancer.
Type:
Application
Filed:
October 7, 2008
Publication date:
May 28, 2009
Applicant:
Societe de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
Inventors:
Gregoire PREVOST, Marie-Christine Brezak Pannetier, Christian Diolez
Abstract: The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in particular be used for preparing a medicine for cancer treatment.
Type:
Application
Filed:
October 6, 2008
Publication date:
May 21, 2009
Applicant:
Societe de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
Abstract: Novel imidazole compounds of the formula wherein the substituents are as defined in the application having antitumoral activity and use thereof.
Type:
Grant
Filed:
May 26, 2004
Date of Patent:
May 19, 2009
Assignee:
Societe de Conseils de Recherches Et d'Applications Scientifiques (S.C.R.A.S.)
Inventors:
Dennis Bigg, Anne-Marie Liberatore, Dominique Pons
Abstract: The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in particular be used for preparing a medicine for cancer treatment.
Type:
Application
Filed:
October 3, 2008
Publication date:
March 26, 2009
Applicant:
Societe de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
Abstract: A subject of the present Application is novel derivatives of benzimidazole and imidazo-pyridine which have a good affinity for certain sub-types of melanocortin receptors, in particular the MC4 receptors. They are particularly useful for treating pathological conditions and diseases in which one or more melanocortin receptors are involved. The invention also relates to pharmaceutical compositions containing said products.
Type:
Grant
Filed:
January 31, 2008
Date of Patent:
March 10, 2009
Assignee:
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Abstract: A compound of the formula wherein the substituents are as defined in the specification and pharmaceutical salts thereof having a good affinity for sub-types of melanocortin receptors making them useful for treating diseases in which such receptors are included such as pain, inflammatory conditions, etc.
Type:
Grant
Filed:
August 11, 2004
Date of Patent:
March 10, 2009
Assignee:
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Abstract: Derivatives of imidazopyridine which have a good affinity for certain sub-types of melanocortin receptors, in particular MC4 receptors and are useful for treating pathological states and diseases in which one or more melanocortin receptors are involved and pharmaceutical compositions containing said products.
Type:
Grant
Filed:
March 29, 2004
Date of Patent:
February 24, 2009
Assignee:
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Abstract: The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in particular be used for preparing a medicine for cancer treatment.
Type:
Grant
Filed:
August 31, 2007
Date of Patent:
February 24, 2009
Assignee:
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Abstract: A subject of the present application is new benzimidazole derivatives of formula in which A, Y, R1, R2, R3 and R4 represent different variable groups. These products have an antagonist activity of GnRH (Gonadotropin-Releasing Hormone). The invention also relates to pharmaceutical compositions containing said products and their use for the preparation of a medicament.
Type:
Grant
Filed:
December 20, 2002
Date of Patent:
February 24, 2009
Assignee:
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Inventors:
Lydie Poitout, Valérie Brault, Eric Ferrandis, Christophe Thurieau