Patents Assigned to Societe de Conseils de Recherches et d'Applications Scientifiques
  • Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
    Patent number: 7122535
    Abstract: A method of treating pain in a warm-blooded animal comprising administering to anwarm-blooded animal in need thereof an amount of a compound of the formula wherein the substituents are defined in accordance with the disclosure.
    Type: Grant
    Filed: July 26, 2004
    Date of Patent: October 17, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Pierre Etienne Chabrier de Lassauniere, Serge Auvin, Dennis Bigg, Michel Auquet, Jeremiah Harnett
  • 4-aminopiperidine and their use as a medicine
    Patent number: 7115634
    Abstract: A subject of the present application is new derivatives of 4-aminopiperidines of formula in which R1, R2 and R3 represent various radical, and their preparation processes by synthetic methods in parallel in liquid and solid phase. These products having a good affinity with certain sub-types of somatostatin receptors, they are particularly useful for treating the pathological states or diseases in which one (or more) somatostatin receptors are involved.
    Type: Grant
    Filed: December 13, 2000
    Date of Patent: October 3, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques
    Inventors: Christophe Thurieau, Jérôme Gonzalez, Christophe Moinet
  • Sustained release formulation of a peptide
    Patent number: 7109166
    Abstract: This invention is directed to a sustained release composition comprised of Compound (A) having the formula or a pharmaceutically acceptable salt thereof, and a copolymer comprised of poly-(I)-lactic-glycolic-tartaric acid wherein the amino group of Compound (A) is ionically bound to a carboxyl group of the copolymer and wherein further the composition may be made into a sustained release pharmaceutical composition with pharmaceutically acceptable carrier(s).
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: September 19, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, SAS
    Inventor: Jacques-Pierre Moreau
  • Polymerization catalysts
    Patent number: 7101959
    Abstract: A subject of the present invention is new compounds having a lanthanide and having a tridentate ligand, a process for their preparation and their use in particular as polymerization catalysts.
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: September 5, 2006
    Assignees: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.), Centre National de la Recherche Scientifique (C.N.R.S.)
    Inventors: Anca Dumitrescu, Heinz Gornitzka, Blanca Martin-Vaca, Didier Bourissou, Guy Bertrand, Jean-Bernard Cazaux
  • Somatostatin analog and uses thereof
    Patent number: 7094753
    Abstract: Claimed is a somatostatin agonist according to formula (I), D-Phe-c(Cys-Tyr(I)-D-Trp-Lys-Val-Cys)-Thr-NH2, ??(I) or a pharmaceutically acceptable salt thereof, and uses thereof.
    Type: Grant
    Filed: November 21, 2002
    Date of Patent: August 22, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, SAS
    Inventors: Thomas D. Gordon, Barry A. Morgan, Michael D. Culler
  • Method for preparing polyesters having intrachain free acid functions
    Patent number: 7094862
    Abstract: The invention relates to a method for preparing polyesters A containing several mid-chain free acid functions by ring-opening polymerisation in the presence of a chain initiator: the benzyl diester of the tartaric acid, the phenyl radical of which is optionally substituted. A: aliphatic based on cyclic esters such as lactides and glycolides.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: August 22, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Jean-Bernard Cazaux, Charles Brigati, Alexandre Louchkoff, Francis Diancourt
  • DNA polymerase inhibitors, mikanolide and dihydromikanolide
    Patent number: 7091239
    Abstract: A method of treating proliferative diseases in warm-blooded animals comprising administering to warm-blooded animals in need thereof an amount of at least one compound selected from the group consisting of mikanolide and dihydromikanolide sufficient to treat said disease.
    Type: Grant
    Filed: June 9, 2004
    Date of Patent: August 15, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Poon Beng Teng, Marie-Christine Brezak Pannetier, Mohamed Moumen, Gregoire Prevost
  • Pharmaceutical compositions which inhibit vascular proliferation and method of use thereof
    Patent number: 7084117
    Abstract: The present invention relates to a method of treating vascular proliferation in a patient in need thereof. The method includes the step of administering a therapeutically effective amount of a type-1 somatostatin agonist to said patient.
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: August 1, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, SAS
    Inventors: Michael Dewitt Culler, Romano Danesi, Guido Bocci, Mario Deltacca
  • Use of stannylenes and germylenes as polymerization catalysts for heterocycles
    Patent number: 7084237
    Abstract: The use of stannylenes and germylenes of general formula (I) wherein: M represents a tin or geranium atom; L1 and L2 independently represent a group of formula: -E14(R14) (R?14) (R?14), -E15(R15) (R?15) or -E16(R16)) or together form a chain of formula -L?1-A- L?2; A represents a saturated or unsaturated chain comprising one, two or three elements of group 14; L?1 and L?2, represent, independently, a group of formula: -E14(R14) (R?14)-, E15(R15)- or -E16-; E14 is an element of group 14; E15 is an element of group 15; E16 is an element of group 16; R14, R?14, R?14, R15, R?15 and R16 represent variable groups as polymerization catalysts of heterocycles.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: August 1, 2006
    Assignees: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.), Centre National de la Recherche Scientifique
    Inventors: Anca Dumitrescu, Heinz Gornitzka, Blanca Martin-Vaca, Didier Bourissou, Guy Bertrand, Jean-Bernard Cazaux
  • Prenyl transferase inhibitors
    Patent number: 7084135
    Abstract: A family of imidazole compounds useful for inhibiting the activity of prenyl transferases.
    Type: Grant
    Filed: December 30, 1999
    Date of Patent: August 1, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, SAS
    Inventors: Thomas D. Gordon, Barry A. Morgan
  • Use of Ginkgo extract
    Patent number: 7078434
    Abstract: The present invention is directed to the use of the extract of Ginkgo biloba leaves or isolated Ginkgolide B (GKB), a component of the extract of Ginkgo biloba leaves in a method for decreasing the expression of peripheral-type benzodiazepine receptor (PBR) in cells of a patient in need thereof. Further, the present invention is directed to the use of the extract of Ginkgo biloba leaves or isolated GKB in a method for decreasing the proliferation of cancer cells in a patient. More particularly, the present invention is directed to the use of the extract of Ginkgo biloba leaves or isolated GKB in a method of decreasing cancer cell proliferation in a patient wherein the cancer cell is human breast cancer cell.
    Type: Grant
    Filed: August 11, 2000
    Date of Patent: July 18, 2006
    Assignees: Societe de Conseils de Recherches et d'Applications Scientifiques SAS, Georgetown University
    Inventors: Katy Drieu, Vassilios Papadopoulos
  • Method for preparing an extract of ginkgo biloba leaves highly enriched in active principles
    Patent number: 7048954
    Abstract: A process for the preparation of an extract of Ginkgo biloba leaves, comprising i. extraction of the dried fragments of Ginkgo biloba leaves in ethanol containing a maximum of 20% by weight of water; ii. concentration of the extract under reduced pressure in the presence of an aqueous solution of sodium chloride and elimination of the dark oil from the remainder of the clear solution; iii. washing of the residual aqueous solution by liquid-liquid extraction with n-hexane, n-heptane or cyclohexane, iv. liquid-liquid extraction of the aqueous phase washed with ethyl acetate; and v. washing of the ethyl acetate phase obtained in stage iv with a sodium chloride solution followed by evaporation to dryness of the washed ethyl acetate phase and use of the resulting extract to treat cerebral and peripheral vascular disorders and neurodegenerative diseases.
    Type: Grant
    Filed: April 9, 2002
    Date of Patent: May 23, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventor: Beng Poon Teng
  • Product inhibiting transduction of G heterotrimeric protein signals combined with another anti-cancer agent for therapeutic use in cancer treatment
    Patent number: 7034024
    Abstract: The invention concerns a product inhibiting transduction of G heterotrimeric protein signals combined with another anti-cancer agent, in particular farnesyltransferase inhibitors, taxol or gemcitabin, for simultaneous, separate or prolonged therapeutic use in cancer treatment.
    Type: Grant
    Filed: November 8, 2000
    Date of Patent: April 25, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Grégoire Prevost, Marie-Odile Lonchampt, Thomas Gordon, Barry Morgan
  • Use of cysteine derivatives for the preparation of a medicament intended to treat pathologies which result from the formation of the heterotrimeric G protein
    Patent number: 7034025
    Abstract: A method of treating cholera or travel diarrhea in a patient in need thereof by an effective amount of a compound of the formula wherein the substrates are defined in the specification or its non-toxic, pharmaceutically acceptable salts.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: April 25, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Grégoire Prevost, Marie-Odile Lonchampt, Thomas Gordon
  • Somatostatin and somatostatin agonists for decreasing body weight
    Patent number: 7034003
    Abstract: The present invention relates to a method of decreasing body weight in a patient. The method includes the step of administering a therapeutically effective amount of a somatostatin or a somatostatin agonist to said patient. A pharmaceutical/cosmetic composition comprises the somatostatin or somatostatin agonist. Such products are used to prepare such compositions for the reduction of body weight in a human or mammalian animal.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: April 25, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, SAS
    Inventors: Michael Anthony Cawthorne, Yong-Ling Liu, Matthew V. Sennitt
  • Method and compositions for treating hyperlipidemia and other conditions
    Patent number: 7026289
    Abstract: The present invention relates to a method of treating hyperlipidemia and to reducing triacylglycerols, glycerol and cholesterol in a patient. The method includes the step of administering a therapeutically effective amount of a type-5 selective somatostatin agonist to said patient. A pharmaceutical composition comprises said agonist and such product is used in the preparation of the composition for use in treating hyperlipidemia or reducing triacylglycerols, glycerol and cholesterol in a patient's body.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: April 11, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, SAS
    Inventors: Michael Anthony Cawthorne, Yong-Ling Liu, Matthew V. Sennitt
  • Farnesyl transferase inhibitors
    Patent number: 7022704
    Abstract: A family of tetrahydroimidazo[1,2a]pyrazine based compounds capable of inhibiting the activity of farnesyl transferase and treating tumors and restenosis having the following structure: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined in the specification.
    Type: Grant
    Filed: October 18, 2002
    Date of Patent: April 4, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Thomas D. Gordon, Barry A. Morgan
  • Derivatives of amidines, their preparation and their use as medicaments
    Patent number: 7019025
    Abstract: Compounds of the formula wherein R1 is alkyl and R2 is alkenyl, alkynyl, allenyl or cyanoalkyl, n is 0 or 1, k is an integer from 1 to 3, X is —(CH2)m— and m is 0 or 1; and pharmaceutical salts thereof useful for inhibiting NO synthases and/or monoamine oxydases.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: March 28, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Pierre-Etienne Chabrier De Lassauniere, Jeremiah Harnett
  • Use of diazepines for preparing medicines for treating pathological conditions or diseases involving one of the growth hormone release inhibiting factor receptors
    Patent number: 7015213
    Abstract: The invention concerns the use of pyrido-thieno-triazolo-diazepins for preparing a medicine for treating pathological conditions or diseases involving one of the growth hormone release inhibiting factor receptors. The invention also concerns novel pyrido-thieno-triazolo-diazepins and therapeutic compositions containing them.
    Type: Grant
    Filed: June 15, 1999
    Date of Patent: March 21, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Dennis Bigg, Anne-Marie Liberatore, Jacques Pommier, John Taylor
  • Crosslinked copolymers based on non-crosslinked polycarboxylic copolymers
    Patent number: 7014845
    Abstract: The invention relates to cross-linked copolymers based on non cross-linked polycarboxylic copolymers, said non cross-linked copolymers containing at least one polysaccharide. The invention also relates to a process for the preparation of these copolymers and their use in particular as a support in pharmaceutical compositions.
    Type: Grant
    Filed: October 3, 2000
    Date of Patent: March 21, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S)
    Inventors: Denis Labarre, Nada Lambert, Cathy Ducos, Françis Diancourt