Patents Assigned to Societe de Conseils de Recherches et
  • N-(iminomethyl)amines derivatives, their preparation, their use as medicines and compositions containing them
    Patent number: 6482822
    Abstract: The invention concerns novel N-(iminomethyl)amine derivatives comprising in their skeleton the aminophenylamine, oxodiphenylamine, carbazole, phenazine, phenoxazine or oxodiphenyl motif, their use as medicines and pharmaceutical compositions containing them. The invention concerns in particular the following compounds: -4-{[2-thienyl(imino)methyl]amino}-N-[2-(phenylamino)phenyl]-benzenebutanamide; -4-{[2-thienyl(imino)methyl]amino}-N-[4-(phenylamino)phenyl]-benzenebutanamide; -N-′[4-(10H-phenothiazin-2-yloxy)phenyl]-2-thiophenecarboximidamide; -4-(4-{[amino(2-thienyl)methylidene]amino}phenyl)-N-(10H-phenothiazin-3-ylH)butanamide; -3-[(3-{[amino(2-thienyl)methylidene]amino}-benzyl)amino]-N-(4-anilinophenyl)propanamide; -N′-(4-{2-[(10H-phenothiazin-3-ylmethyl)amino]ethyl}phenyl-2-thiophene carboximidamide.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: November 19, 2002
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Dennis Bigg, Pierre-Etienne Chabrier de Lassauniere, Serge Auvin, Jeremiah Harnett, Gérard Ulibarri
  • New analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them
    Publication number: 20020160994
    Abstract: A process for the preparation of a compound of the formula 1
    Type: Application
    Filed: January 30, 2002
    Publication date: October 31, 2002
    Applicant: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)
    Inventors: Dennis Bigg, Olivier Lavergne, Francesc Pla Rodas, Jacques Pommier, Gerard Ulibarri, Jerry Harnett, Alain Rolland, Anne-Marie Liberatore, Christophe Lanco, Jean-Bernard Cazaux, Christine Le Breton, Eric Manginot
  • Camptothecin tetracyclic analogues, preparation, method, applications as medicines and pharmaceutical compositions containing them
    Patent number: 6436951
    Abstract: The invention relates to new tetracyclic analogues of camptothecin, their preparation processes, their use as medicaments and the pharmaceutical compositions containing them. Said analogues, which include in particular 3-hydroxy-3-(4-oxo-4,6-dihydroindolizino [1,2-b] quinoline-2-yl)pentanoic acid, have a powerful biological activity inhibiting topoisomerase I and/or topoisomerase II.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: August 20, 2002
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Dennis Bigg, Olivier Lavergne, Alain Rolland, Christophe Lanco, Gerard Ulibarri
  • Device for local administration of solid or semi-solid formulations and delayed-release formulations for proposal parental administration and preparation process
    Publication number: 20020111603
    Abstract: A method for implanting or inserting a solid or semisolid formulation containing at least one active principle uses a device comprising one part set inside the body of the patient and which conditions the solid or semisolid form, brings these conditioning action to the deposit site, injects or inserts in this deposit site, and withdraws after injection or insertion, with one part remaining outside and activating the functions of the device. The invention also concerns a sustained-release solid formulation for parenteral administration comprising a homogeneous mixture of an active principle in non-dispersed state and of a biologically compatible and biodegradable excipient, in which the amount of active principle is at least 50% by weight.
    Type: Application
    Filed: February 1, 2002
    Publication date: August 15, 2002
    Applicant: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATION
    Inventor: Roland Cherif Cheikh
  • Imidazolyl derivatives
    Patent number: 6420555
    Abstract: The present invention is directed to imidazolyl derivatives of formula (I), wherein the variables are defined in the specification, which are useful as prenyl transferase inhibitors.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: July 16, 2002
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Zheng Xin Dong, Yeelana Shen
  • Use of a flavonoid extract of ginkgo biloba substantially devoid of terpenes, in the dentibuccal field, and composition containing such extract
    Publication number: 20020064571
    Abstract: Cosmetic compositions containing the flavonoid extract of ginkgo biloba leaves substantially free of terpenes and a cosmetic carrier.
    Type: Application
    Filed: November 26, 2001
    Publication date: May 30, 2002
    Applicant: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)
    Inventor: Joseph O'Reilly
  • New derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
    Publication number: 20020045753
    Abstract: A compound of the formula 1
    Type: Application
    Filed: September 4, 2001
    Publication date: April 18, 2002
    Applicant: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)
    Inventors: Pierre Etienne Chabrier de Lassauniere, Serge Auvin, Dennis Bigg, Michel Auguet, Jeremiah Harnett
  • New derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
    Publication number: 20020042511
    Abstract: A compound of the formula XXV (H) wherein the substituents are defined as set forth in the specification which are useful intermediates for the production of derivatives of 2-(iminomethyl)-imino-phenyl having inhibitory activity on NO-synthase enzymes.
    Type: Application
    Filed: September 17, 2001
    Publication date: April 11, 2002
    Applicant: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)
    Inventors: Pierre Etienne Chabrier de Lassauniere, Serge Auvin, Dennis Bigg, Michel Auguet, Jeremiah Harnett
  • Method for preparing an injectable preparation and device for implementing same
    Patent number: 6349850
    Abstract: A method comprising the following steps: preparing in a vacuum a dry form (18) of an active principle, as well as a liquid (22), and drawing this liquid into the dry form, by the action of the vacuum to obtain an injectable preparation. The device comprises a gastight syringe (19) to condition under vacuum the dry form, a reservoir (12) containing the liquid (22) and a cap (29) forming a connector between the syringe and the liquid reservoir, the injection needle (25) of the syringe being driven into the septum (24) of the cap (29). The invention enables a preparation which is directly injectable by an automatic rehydration step to be obtained; indeed, after activation, the extemporaneous preparation is automatic since the device elements move by themselves under the action of the liquid which is drawn by suction into the volume under vacuum containing the solid formulation (18).
    Type: Grant
    Filed: February 18, 1999
    Date of Patent: February 26, 2002
    Assignee: Societe de Conseils de Recherches et D'Applications Scientifiques SCRAS
    Inventor: Roland Cherif Cheikh
  • Phencyclidine derivatives, preparation method and pharmaceutical compositions containing same
    Patent number: 6342511
    Abstract: The invention concerns novel phenylcyclidine derivatives with selective affinity for low affinity receptors, methods for preparing them, pharmaceutical compositions containing them and their use as protective agents for central or peripheral nervous system cells against acute or chronic degeneration, or as an anticonvulsant.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: January 29, 2002
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Jean-Marc Kamenka, Jacques Hamon, Jacques Vignon
  • 2-(iminomethyl) amino-phenyl derivatives, preparation, application as medicines and pharmaceutical compositions containing same
    Patent number: 6340700
    Abstract: A compound of the formula wherein the substituents are defined as in the specification and their pharmaceutically acceptable salts having NOS and ROS activity.
    Type: Grant
    Filed: September 22, 1999
    Date of Patent: January 22, 2002
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Pierre Etienne Chabrier de Lassauniere, Serge Auvin, Dennis Bigg, Michel Auguet
  • Use of a flavonoid extract of ginkgo biloba substantially devoid of terpenes, in the dentibuccal field, and composition containing such extract
    Patent number: 6340456
    Abstract: The invention concerns the use of a flavoniodic extract of ginkgo biloba leaves, and more specifically an extract devoid of terpenes for oral hygiene. The invention also concerns a composition for oral hygiene containing such an extract.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: January 22, 2002
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventor: Joseph O'Reilly
  • New derivatives of 2-(iminomethyl) amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
    Publication number: 20020007062
    Abstract: A method for treating neurodegenerative diseases in a warm-blooded animal comprising administering to a warm-blooded animal in need thereof an amount of a compound of the formula 1
    Type: Application
    Filed: June 15, 2001
    Publication date: January 17, 2002
    Applicant: SOCIETE DE CONSEILS DE RECHERCHES ET D' APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)
    Inventors: Pierre Etienne Chabrier de Lassauniere, Serge Auvin, Dennis Bigg, Michel Auguet, Jeremiah Harnett
  • Comptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues
    Patent number: 6339091
    Abstract: The compound of the formula wherein the substituents are defined as in the specification and its non-toxic, pharmaceutically acceptable salts which are useful for the treatment of viral infections, parasitic diseases and the treatment of cancer.
    Type: Grant
    Filed: June 14, 1999
    Date of Patent: January 15, 2002
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Dennis Bigg, Olivier Lavergne, Francesc Pla Rodas, Jacques Pommier, Gerard Ulibarri, Jerry Harnett, Alain Rolland, Anne-Marie Liberatore, Christophe Lanco, Jean-Bernard Cazaux, Christine Le Breton, Eric Manginot
  • Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
    Patent number: 6335445
    Abstract: A compound selected from the group consisting of a compound of the formula wherein A is selected from the group consisting of and the other substituents are defined in the specification having an inhibitory activity of NO-synthase enzymes producing nitrogen mono-oxide and/or an activity which traps the reactive oxygen species.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: January 1, 2002
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Pierre Etienne Chabrier de Lassauniere, Serge Auvin, Dennis Bigg, Michel Auguet, Jeremiah Harnett
  • Therapeutic use of a thienylcyclohexylamine derivative
    Publication number: 20010056091
    Abstract: A method of inhibiting effects of exogenous neurotoxic or neurotoxinic products in warm-blooded animals comprising administering to warm-blooded animals before exposure to said products an inhibitorily effective amount of reversible cholinesterase inhibitor selected from the group consisting of pyridostigmine and physostigmine followed by administration of an inhibitorily effective amount of 2-methyl-1-(1-piperidinyl)-1-(2-thienyl)-cyclohexane in substantially pure racemic, diastereoisomeric or enantiomeric form.
    Type: Application
    Filed: April 13, 2001
    Publication date: December 27, 2001
    Applicant: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S)
    Inventors: Guy Lallement, Pierre D'Arbigny, Jean-Marc Kamenka
  • Ginkgo biloba flavonoid extract free of terpene and/or with a high flavonoid heteroside content
    Publication number: 20010043976
    Abstract: A process for preparing a flavonoid extract from the leaves of ginkgo biloba comprising multiple distractions of the leaves of the ginkgo biloba with solvents wherein at least one of the extraction stages is a deterpenation step using a solvent of the formula RC(O)OR′ wherein R and R′ are individually lower alkyl.
    Type: Application
    Filed: April 18, 2001
    Publication date: November 22, 2001
    Applicant: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)
    Inventor: Joseph O'Reilly
  • Analogues of camptothecin, preparation procedures, their application as medicines and the pharmaceutical compositions comprising them
    Patent number: 6313135
    Abstract: A compound of the formula wherein the substituents are as defined in the specification and a method of inhibiting tumors.
    Type: Grant
    Filed: June 4, 1999
    Date of Patent: November 6, 2001
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Dennis Bigg, Olivier Lavergne, Francesc Pla Rodas, Jacques Pommier, Gerard Ulibarri
  • Methods and apparatus for the delivery of solid drug compositions
    Patent number: 6306420
    Abstract: The invention features an implantable device for the automatic delivery of an active ingredient according to an adjustable delivery profile. The device includes a housing; a reservoir operatively connected to the housing and arranged to store a solid composition including the active ingredient; an actuator arranged within the housing to move the solid composition from the reservoir to a transit area, wherein the solid composition exits the housing at the transit area; a controller that acts on the actuator to adjust movement of the solid composition out of the housing according to the adjustable delivery profile; and a power source arranged to provide energy to the actuator and the controller. The solid composition can be an elongate, solid composition comprising a drug, and up to 90% of a carrier, wherein the composition has a cross-section of less than 0.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: October 23, 2001
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventor: Roland Cherif Cheikh
  • Metal complexes with a tridentate ligand as polymerization catalysts
    Patent number: 6303807
    Abstract: The invention concerns novel compounds having the elements of group 11, 12 or 14; and a tridentate ligand, a method for preparing them and their use in particular as polymerisation catalyst.
    Type: Grant
    Filed: December 23, 1999
    Date of Patent: October 16, 2001
    Assignees: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.), Centre National de la Recherche Scientifique (C.N.R.S.)
    Inventors: Guy Bertrand, Jean-Bernard Cazaux, Jean-Luc Faure, Hanh Nguyen, Régis Reau