Abstract: The present invention relates to a process for producing amino/guanidinothiosulfonic acid, which comprises treating a styrenedivinylbenzene copolymer sulfonate of amino/guanidinoethyl disulfoxide into contact with an alkali, selectively eluting amino/guanidinosulfinic acid, then reacting this product in a non-aqueous solvent in the presence of a base, and passing the reaction product through a weakly acidic cation exchange resin column; in accordance with the present invention, hypotaurine, thiotaurine and the like having a high purity can industrially be produced.

Abstract: Taurine analogues are used for scavenging active oxygen compounds and preventing and minimizing damage to the skin from ultraviolet rays. The taurine analogues have the following formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification.

Abstract: Disclosed are a method of detecting bitter or odor odorous substances, which method comprises adsorbing the bitter or odorous substances onto an immobilized bilayer film and directly, quantitatively, separately, and selectively detecting the adsorbed bitter or odorous substances, and an apparatus therefor.

Abstract: A method of determining the amount of the substances or ions contained in an ionic solution or a non-deionized solution by measuring the frequency of a one side barrier-covered crystal oscillator comprising a crystal oscillator, a barrier to cover over one of the electrodes of the crystal oscillator through a predetermined insulative space so as to prevent the ionic solution or the non-deionized solution from permeating therethrough and an adsorption film cast on the other electrode of the crystal oscillator, in situ in the state that the one side barrier-covered crystal oscillator is dipped in the ionic solution or the non-deionized solution, and the one side barrier-covered crystal oscillator used therefor.

Abstract: The present invention concerns an enzyme inhibitor containing the compound represented by the following formula (I) as an effective ingredient: ##STR1## where R represents hydrogen or substituted or not substituted alkyl group, alkenyl group, aryl group or aralkyl group, X represents OR' or NR"R"', in which R', R" and R'" represent respectively hydrogen or substituted or not substituted alkyl group, alkenyl group, aryl group or aralkyl group.The enzyme inhibitor according to the present invention can effectively inhibit aldose reductase, glyoxalase I and reverse transcriptase.

Abstract: A cosmetic comprising pantetheine-S-sulfonic acid and/or its salt. A pantetheine-S-sulfonate can prevent pigmentation on the skin. The present invention provides a cosmetic having an extremely high beautifying effect.

Abstract: Pantetheine-S-sulfonic acid and/or its salt(s) have(has) an effect of curing and preventing pigmentation in the skin, an effect of improving rough skin and a curative effect to wounds, burns and the like, therefore being used for agents for epidermis.

Abstract: A lipid metabolism improving drug or pharmaceutical composition contains pantetheine-S-sulfonic acid as an active ingredient. When an effective dose of pantetheine-S-sulfonic acid or a pharmaceutically active, non-toxic salt thereof is administered to an animal, such as a human, in pure form or composition form, the lipid concentration in the plasma is lowered, lipid peroxide concentration in the serum and liver is lowered, B-lipo protein-cholesterol concentration in serum is decreased and HDL-cholesterol concentration is increased.

Abstract: The present invention relates to a nylon capsule to whose pore portion is applied a bimolecular membrane so that the capsule can respond to pH.The nylon capsule accommodates various matters such that they can be released into the outside depending on the change of pH. The nylon capsule is useful, for example, for the missile treatment of anticancer drugs, and as a gradually-releasing microcapsule.

Abstract: Hexamethylene.bis-dicyandiamide is safely prepared in good yield and desired purity by a novel method which comprises reacting N-cyano-O (or S)-alkyl-iso (or isothio) urea with hexamethylenediamine. The desired product is useful as an intermediate of chlorhexidine which is an antibacterial agent.

Abstract: Novel amidoxime derivatives having the following structural formula (IV) of (IV'): ##STR1## wherein R.sub.1 represents methyl or ethyl group and R.sub.2 represents hydrogen or methyl group, useful as a raw material for 3-amino-5-methyl isoxazole, are prepared from .beta.-amino crotonitrile. Said isoxazole, useful as an intermediate for various medicines, may be prepared without producing any by-products of isomer.

Abstract: Salt of pantothenic acid and salt of cystamine or cysteamine are caused to react under the presence of an accelerator selected from the group consisting of carbodiimides and N-hydroxy compounds without any pretreatment thereby producing pantethine or pantetheine, and the pantetheine is oxidized to produce pantethine which is a precursor of co-enzyme A.