Abstract: By reacting 1-5.5M nitric acid with from 45 to 170 mmol of primary C.sub.1 -C.sub.5 -alkanol per l of nitric acid, an improved preparation is obtained for the local treatment of changes in skin and mucous membrane and of infections of the skin and mucous membrane. The preparation comprises 1-5.5M nitric acid, not more than 170 mmol of C.sub.1 -C.sub.5 -alkanoic acid per l of solution, and nitrate reduction products in a concentration corresponding to from 0.1 to 6 mg of nitrite per ml of solution. The preparation is notable for a good activity and a low risk of side effects.

Abstract: An antisun product which contains, besides cosmetic auxiliaries and sunscreen agents and/or sun blocks, an effective amount of deproteinated haemodialysate of mammalian blood or an active fraction thereof results in improving the condition of the skin and in reducing or avoiding the adverse effects of exposure to the sun. The composition is suitable for both prophylaxis and aftercare.

Abstract: The compounds of the formula I exert a pronounced specific cytoprotective effect; they can be used for the treatment of acute and chronic inflammations and organ ischemias caused by narrowing of vessels. R.sup.1 denotes an aliphatic radical having 9 to 19 C atoms in the straight chain, R.sup.2 denotes the acyl radical of a saturated or unsaturated fatty acid having 14 to 24 C atoms, and X denotes a --CH.sub.2 CH.sub.2 --or --CH.dbd.CH-- group. The invention relates to pharmaceutical products in which the active ingredient is the said compounds, as well as to those compounds I in which R.sup.2 denotes the acyl radical of an unsaturated fatty acid, and to the process for the preparation thereof.

Abstract: New compounds of the formula (I)-D and (I)-L as shown in the sheet of formulae are described, for example D- and L-erythro-1-(.beta.-D-glycopyranosyloxy)-3-hydroxy-2-palmitoylamino-4-tran s-octadecene, which exert actions promoting wound healing and cell and tissue regeneration, and can be used therapeutically for the treatment of wounds of any cause. They are prepared in good yield and in a stereochemically homogeneous form from ceramides of the formula (II)-D and/or (II)-L. The process comprises the protection of the 1-hydroxyl group, esterification of the 3-hydroxyl group, elimination of the 1-hydroxyl protective group, reaction with the trifluoroacetimidate or trichloroacetimidate of a 2,3,4,6-tetraacylated D-glucose and elimination of the O-acyl groups.

Abstract: The invention relates to a new process for the preparation of the sphingosine derivatives described in European Patent Application No. 146,810, of the formula: ##STR1## It comprises protecting D-galactose in the 4,6-position and oxidizing it to the corresponding D-threose protected in the 2,4-position, condensing an aliphatic chain (R.sup.3) onto the latter by a Wittig reaction, converting the free hydroxyl group into a azido group and splitting off the protective group, protecting the resulting 2-azido-1,3-dihydroxy compound selectively in the 1-position and blocking it in the 3-position, liberating the 1-hydroxy group again, glycosidating the resulting compound or the abovementioned 2-azido-1,3-dihydroxy compound with the 0-trifluoro- or 0-trichloro-acetimade or the 1-halogen derivative of a 2,3,4,6-0-tetraacyl-D-glucose, splitting off the acyl groups of these and the protective group in the 3-position, converting the azido group into an amino group and acylating the amino compound with a fatty acid R.sup.

Abstract: Stable injection solutions of radiodiagnostic aids ready for use are obtained by addition to the organ-or tissue-specific carrier, before, during or after the labeling with the pertechnetate, of a compound of the formula: ##STR1## in which R denotes hydrogen, and R' denotes a sulpho- or a carboxymethyl group, or R and R' each denote a sulpho- or a carboxymethyl group, or a water-soluble salt thereof, as stabilizer. These compounds do not alter the specific organ or tissue distribution of the carrier.

Abstract: In apparatus for receiving and reinfusing a patient's own blood, a rigid container encloses a readily deformable inner container, blood being drawn into the readily deformable container by suction and being displaced therefrom by pressure applied between the outer container and the inner container, for pressure reinfusion. Alternatively, the apparatus has a concertina-like container which is held in its expanded condition by a support structure during the blood-intake suction phase, the blood being displaced from the container back into the patient by compression of the container. In another alternative form, the container is a concertina-like container with a high degree of resiliency adapted to expand it into an expanded condition, the container drawing blood from the patient by being compressed before being connected to the patient and then sucking the blood into the container by expansion under the effect of the resiliency.

Abstract: A vaccine for curative and prophylactic treatment of urinary tract infections in humans. The vaccine contains inactivated bacteria which originate from the cultures of 8 to 14 uropathogenic bacteria strains isolated from the urine of a person suffering from a urinary tract infection and aluminum phosphate in an amount of 1.5-10 mg of AlPO.sub.4 per ml of solution. Such bacteria are of the species E. coli, Klebsiella pneumoniae, Proteus mirabilis, Proteus morganii and Streptococcus faecolis.

Abstract: The invention concerns a process for obtaining cell respiratory stimulating active agents having a molecular weight in the range of about 300 to 8000 Dalton, by defibrination of calves blood, hemolyzing the solution obtained thereby, separating the proteins and substances having a molecular weight of over about 8000 Dalton comprised in the hemolyzed solution by a membrane separation procedure, concentrating the resulting protein- and high molecular weight-freed solution under reduced pressure at a temperature not exceeding 40.degree. C. to a density in the range of 1.10 to 1.15 g/ml at 20.degree. C.

Abstract: The composition consists of an aqueous solution of nitric acid and nitrous acid with a pH below 1 and an acid equivalent of from 6 to 10 mmole/ml; the amount of nitrous acid corresponds to 0.01 to 5 mg of nitrite (NO.sub.2.sup.-) per ml. Additionally, the solution preferably contains acetic acid, oxalic acid and lactic acid as well as copper and cadmium ions. For the preferred composition, the preparation takes place by mixing the components and letting them react to the end or by an oxidative method, in the course of which nitrous acid is formed. The composition is suitable for the local treatment of superficial lesions of the skin and mucous membranes in the fields of cosmetics and medicine, particularly for certain malignant tumors. Experimentally, the effectiveness can be checked by two biological tests developed for this purpose.

Abstract: A mammal organ, for example the thymus, or a cell culture is comminuted to form a slurry, accompanied by cell disintegration, high molecular weight substances are precipitated by heating and removed by centrifuging, and residual substances of molecular weight greater than 10,000 are separated out by ultrafiltration; finally, the salts are substantially removed by electrodialysis. A biologically active, low-salt, sterile, pyrogen-free and antigen-free complete extract is obtained and, in contrast to all known processes, no foreign substance or auxiliary, other than water--not even a preservative or a carrier for separation methods--is used.

Abstract: In apparatus for receiving and reinfusing a patient's own blood, a rigid container encloses a readily deformable inner container, blood being drawn into the readily deformable container by suction and being displaced therefrom by pressure applied between the outer container and the inner container, for pressure reinfusion. Alternatively, the apparatus has a concertina-like container which is held in its expanded condition by a support structure during the blood-intake suction phase, the blood being displaced from the container back into the patient by compression of the container. In another alternative form, the container is a concertina-like container with a high degree of resiliency adapted to expand it into an expanded condition, the container drawing blood from the patient by being compressed before being connected to the patient and then sucking the blood into the container by expansion under the effect of the resiliency.

Abstract: Glycolipids having cell- and tissue-regenerating properties are isolated from the blood or organ homogenates of mammals by subjecting the starting material to autolysis and dialysis against an alcoholic-aqueous medium. The glycolipids can be isolated, and purified, from the resulting crude product by precipitation with ethanol or extraction followed by chromatography. The process gives relatively high yields of active compounds; it is outstandingly suitable for industrial application.

Abstract: A hose clamp, which may be completely made of plastic, comprises two clamping stirrups which can be anchored in clamping position by interaction of a tongue on one stirrup and a toothed section of the other stirrup. The hose to be clamped can either extend through coaxial openings of the clamping stirrups or be introduced between the stirrups from the side. In the first case, the clamp can only be removed over a free end of the hose while, in the second case, the clamp can be positioned at any point along the hose as desired.

Abstract: The assembly comprises a blood collection vessel, a flexible tube removably connected to the collection vessel and a flow control mechanism for regulating the flow of liquid into or out of the collection vessel. One of the shaped sections of the collection vessel has a size effective to be grasped by the hand of an operator. Inlet and outlet means are disposed at opposite ends of the vessel so that blood may be introduced into the vessel at one end and discharged at the other end when desiring to place the blood back into the person. Other specific features of the invention include the particular structural configuration of the flow control mechanism the disposition of a flexible tube between the flow control mechanism and the collection vessel and other features of the collection vessel.

Abstract: A colloidal solution of human serum albumin is prepared by mixing an aqueous solution of the latter with a non-ionic surface-active agent and an acid solution of a tin(II) salt, adjusting the pH to 3.5 to 8.0 and heating at a constant temperature between 45.degree. and 100.degree. C. until complete hydrolysis of the tin(II) salt and denaturation of the albumin have taken place; the colloidal solution can also be lyophilized. By treating the solution or the lyophilizate with a .sup.99m Tc-pertechnetate solution, a colloidal preparation is obtained for scintigraphy of the reticuloendothelial system or the lymphatic system. By suitable pH adjustment, the process makes it possible selectively to obtain colloids with a particle size of, for example, 3.0-0.2 or 0.2-0.03 or below 0.03 .mu.m.

Abstract: The organ transplants are intended to be used as a replacement (prostheses) for organs or parts of organs, for examples arteries or veins, which have undergone pathological change or are functionally impaired. The organs, which are taken from a fish, bird or higher mammal, are subjected to crosslinking of the amino groups and of the alcoholic hydroxyl groups of the peptide chains of the intercellular matix by means of a di-, tri- or poly-carboxylic acid. It is advantageous subsequently to treat the crosslinked product with a dialdehyde, in order to bind amino groups which have not reacted, or to free the crosslinked product from material which potentially may act as an antigen, by hydrolysis with ficin, papain or a protease having a smaller action. After the hydrolysis, a comprehensive crosslinking is appropriately ensured using a dialdehyde or a di-, tri- or poly-carboxylic acid.

Abstract: An apparatus for sucking blood out of body cavities blood collecting vessel is at one end connected via a flexible line to a source of vacuum, and, at the other provided integrally with a suction tube. The lower portion of the suction tube includes suction orifices and projects into a basket acting as a filter carrier. This basket includes a series of suction slots located only in the lower part of the wall of the basket to avoid aspiration of air. On its outer surface, the basket is surrounded by a filter fabric which is fixed in an annular groove. Structures alternative to the basket are also disclosed.

Abstract: A radioactive composition for the scintigraphic imaging of the hepatobiliary system is disclosed, the composition comprising a complex of .sup.99m Tc with a [2,6-di(lower)alkyl or 2,4,6-tri(lower)alkyl-acetanilido]-iminodiacetic acid having a total of at least 3 carbon atoms in the alkyl groups, or a salt thereof, in sterile aqueous solution. In a preferred composition the complex contains in addition a tin salt and is prepared directly prior to use by reacting NaTcO.sub.4 with SnCl.sub.2 and the iminodiacetic acid.

Abstract: For labelling organic or anorganic substances with technetium-99m in the heterogenous phase, an aqueous solution of the substance to be labelled is mixed with a pertechnetate and an aqueous suspension of Sn.sub.2 Fe(CN).sub.6, Sn.sub.3 [Fe(CN).sub.6 ].sub.2, SnS or SnTe and the solution of the labelled substance is separated from the solid phase after completion of the reduction of the pertechnetate. In particular, the reducing agent can be in a vial, in lyophilized or adsorbed form, as appropriate together with the substance to be labeled.