Patents Assigned to Solulink Bioscience, Inc.
  • NOVEL HYDRAZONE-BASED AND OXIME-BASED FLUORESCENT AND CHROMOPHORIC/PRO-FLUORESCENT AND PRO-CHROMOPHORIC REAGENTS AND LINKERS
    Publication number: 20140171635
    Abstract: Novel Hydrazone-based Fluorescent and Pro-Fluorescent Reagents and Linkers, including conjugationally extended hydrazine compositions, fluorescent hydrazone compositions, methods of the formation of hydrazones from the reaction of conjugationally extended hydrazines with conjugationally extended carbonyls, and methods of their use in assays systems are described. Use of these conjugationally compositions for direct colorimetric and fluorometric assays wherein a chromophore or the fluorophore is incorporated into the linker that is positioned between a reactive linking moiety and a biotin molecule.
    Type: Application
    Filed: August 14, 2013
    Publication date: June 19, 2014
    Applicant: Solulink Biosciences, Inc.
    Inventors: David A. Schwartz, Leopold Mendoza
  • Hydrazone-based and oxime-based fluorescent and chromophoric/pro-fluorescent and pro-chromophoric reagents and linkers
    Patent number: 8541555
    Abstract: Conjugationally extended hydrazine compositions of the formula (RR2)N(H)n(NH2)n, fluorescent hydrazone compositions of the formula (RR2)NN?C(R1R2), methods of the formation of hydrazones from the reaction of conjugationally extended hydrazines with conjugationally extended carbonyls and methods of their use in assays systems are described. Use of these conjugationally extended hydrazine and oxime compositions for direct calorimetric and fluorometric assays wherein a chromophore or the fluorophore is incorporated into the linker that is positioned between a reactive linking moiety and a biotin molecule.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: September 24, 2013
    Assignee: Solulink Biosciences, Inc.
    Inventors: David A. Schwartz, Leopoldo Mendoza
  • Triphosphate oligonucleotide modification reagents and uses thereof
    Patent number: 7999098
    Abstract: Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
    Type: Grant
    Filed: December 11, 2006
    Date of Patent: August 16, 2011
    Assignee: Solulink Biosciences, Inc.
    Inventors: David A. Schwartz, Richard I. Hogrefe
  • Hydrazine-based and carbonyl-based bifunctional crosslinking reagents
    Patent number: 7462689
    Abstract: Reagents and methods are provided for crosslinking and immobilizing biomolecules, drugs and synthetic polymers. The reagents possess (i) a thiol or amino reactive group; and (ii) a hydrazino or oxyamino moiety. Conjugates and immobilized biomolecules are also provided.
    Type: Grant
    Filed: November 24, 2003
    Date of Patent: December 9, 2008
    Assignee: Solulink Biosciences, Inc.
    Inventor: David A. Schwartz
  • Hydrazine-based and carbonyl-based bifunctional crosslinking reagents
    Patent number: 6800728
    Abstract: Reagents and methods are provided for crosslinking and immobilizing biomolecules, drugs and synthetic polymers. The reagents possess (i) a thiol or amino reactive group; and (ii) a hydrazino or oxyamino moiety. Conjugates and immobilized biomolecules are also provided.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: October 5, 2004
    Assignee: Solulink Biosciences, Inc.
    Inventor: David A. Schwartz
  • Triphosphate oligonucleotide modification reagents and uses thereof
    Patent number: 6686461
    Abstract: Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
    Type: Grant
    Filed: August 1, 2000
    Date of Patent: February 3, 2004
    Assignee: Solulink Bioscience, Inc.
    Inventors: David A. Schwartz, Richard I. Hogrefe