Patents Assigned to Solulink Incorporated
  • Functional biopolymer modification reagents and uses thereof
    Patent number: 7732628
    Abstract: Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that incorporate the reagents provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
    Type: Grant
    Filed: September 8, 2004
    Date of Patent: June 8, 2010
    Assignee: Solulink Incorporated
    Inventors: David A. Schwartz, Richard I. Hogrefe
  • Hydrazine-based and carbonyl-based bifunctional crosslinking reagents
    Publication number: 20030013857
    Abstract: Reagents and methods are provided for crosslinking and immobilizing biomolecules, drugs and synthetic polymers. The reagents possess (i) a thiol or amino reactive group; and (ii) a hydrazino or oxyamino moiety. Conjugates and immobilized biomolecules are also provided.
    Type: Application
    Filed: March 22, 2001
    Publication date: January 16, 2003
    Applicant: Solulink Incorporated
    Inventor: David A. Schwartz
  • Functional biopolymer modification reagents and uses thereof
    Patent number: RE46171
    Abstract: Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that incorporate the reagents provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: October 4, 2016
    Assignee: SOLULINK, INCORPORATED
    Inventors: David A. Schwartz, Richard I. Hogrefe