Abstract: The present invention is related to a nucleic acid molecule comprising a double-stranded structure, wherein the double-stranded structure is formed by a first strand and a second strand, wherein the first strand consist of the following nucleotide sequence 5? acGaGcUgGaCcAcUgGuCdTsdT 3?, and the second strand consists of the following nucleotide sequence 5? GAcCaGuGgUcCaGcUcGudTsdT 3?, wherein a minor nucleotide indicates that the nucleotide is 2?-F modified and an underlined nucleotide indicates that the nucleotide is 2?-0-methyl modified and wherein dTsdT indicates that at the 3? end a dinucleotide is attached consisting of two dT nucleotides, wherein said two dTs are covalently linked through a phosphorothioate bond.

Abstract: The present invention is related to a nucleic acid molecule comprising a double-stranded structure, wherein the double-stranded structure is formed by a first strand and a second strand, wherein the first strand consist of the following nucleotide sequence 5? acGaGcUgGaCcAcUgGuCdTsdT 3?, and the second strand consists of the following nucleotide sequence 5? GAcCaGuGgUcCaGcUcGudTsdT 3?, wherein a minor nucleotide indicates that the nucleotide is 2?-F modified and an underlined nucleotide indicates that the nucleotide is 2?-O-methyl modified and wherein dTsdT indicates that at the 3? end a dinucleotide is attached consisting of two dT nucleotides, wherein said two dTs are covalently linked through a phosphorothioate bond.