Abstract: Thiopheneprymidinone compounds useful in therapy, especially for use in the treatment and/or prevention of a steroid hormone dependent disorder, preferably a steroid hormone dependent disease or disorder requiring the inhibition of a 17?-hydroxysteroid dehydrogenase (17?-HSD) such as 17?-HSD type 1, type 2 or type 3 enzyme.
Type:
Application
Filed:
June 7, 2004
Publication date:
February 10, 2005
Applicant:
Solvay Pharmaceuticals B.V.
Inventors:
Kristiina Waehaelae, Annamaria Lilienkampf, Sari Alho, Kaisa Huhtinen, Nina Johansson, Pasi Koskimies, Kimmo Vihko
Abstract: An immediate release pharmaceutical formulation of a poorly water-soluble biologically active substance with enhanced bio-availability, the formulation being a homogeneous and thermostable solid solution, and the solid solution including as percentages of the total weight of the formulation: a) 10 to 50% of the active substance; b) 20 to 70% of a non-ionic hydrophilic surfactant which is liquid between 15 and 30° C.; c) 5 to 70% of a pharmaceutically acceptable organic polymer or polymer mixture which is liquid above 60° C. and solid below 30° C., and d) optionally, 1 to 10% of a disintegrating agent; as well as active substances formulated into such form, and methods for producing such formulations.
Abstract: The invention relates to novel phenylpiperazine derivatives of the formula wherein: —R represents the group (a) or (b) as indicated in the description. These compounds are (partial) D2 receptor agonists and are usefull for treating CNS disorders, in particular Parkinson's disease.
Type:
Grant
Filed:
January 30, 2003
Date of Patent:
December 7, 2004
Assignee:
Solvay Pharmaceuticals B.V.
Inventors:
Roelof W. Feenstra, Eric Ronken, Cornelis G. Kruse, Andrew C. McCreary, Gustaaf J. M. van Scharrenburg
Abstract: This invention relates to newly identified polypeptides which have zinc metalloprotease activities and are referred to as IGS5, and polynucleotides encoding such polypeptides, to their use in therapy and in identifying compounds which may be stimulators and/or inhibitors which are useful in therapy, and to production of such polypeptides and polynucleotides.
Type:
Application
Filed:
June 18, 2004
Publication date:
November 11, 2004
Applicant:
Solvay Pharmaceuticals B.V.
Inventors:
Willy Deleersnijder, Rico Wiegers, Michael Weske
Abstract: The present invention relates to novel identified polynucleotides, polypeptides encoded by them and to the use of such polynucleotides and polypeptides, and to their production. More particularly, the polynucleotides and polypeptides of the present invention relate to the G-protein coupled receptor family, referred to as IGS1-family. The invention also relates to inhibiting or activating the action of such polynucleotides and polypeptides, to a vector containing said polynucleotides, a host cell containing such vector and transgenic animals where the IGS1-gene is either overexpressed, misexpressed, underexpressed or suppressed (knock-out animals). The invention further relates to a method for screening compounds capable to act as an agonist or an antagonist of said G-protein coupled receptor family IGS1 and the use of IGS1 polypeptides and polynucleotides and agonists or antagonists to the IGS1 receptor family in the treatment of psychiatric and CNS disorders.
Type:
Application
Filed:
December 10, 2003
Publication date:
September 30, 2004
Applicant:
Solvay Pharmaceuticals B.V.
Inventors:
Willy Deleersnijder, Guy Nys, Fan Zhang
Abstract: The present invention relates to novel identified polynucleotides, polypeptides encoded by them and to the use of such polynucleotides and polypeptides, and to their production. More particularly, the polynucleotides and polypeptides of the present invention relate to the G-protein coupled receptor family, referred to as IGS4-family. The invention also relates to inhibiting or activating the action of such polynucleotides and polypeptides, to a vector containing said polynucleotides, a host cell containing such vector and transgenic animals where the IGS4-gene is either overexpressed, misexpressed, underexposed or suppressed (knock-out animals).
Type:
Application
Filed:
February 4, 2004
Publication date:
September 9, 2004
Applicant:
Solvay Pharmaceuticals, B.V.
Inventors:
Jakob Venema, Claudia Berger, Christiane Loken, Willy Deleersnijder, Guy Nys
Abstract: This invention relates to newly identified polypeptides which have zinc metalloprotease activities and are referred to as IGS5, and polynucleotides encoding such polypeptides, to their use in therapy and in identifying compounds which may be stimulators and/or inhibitors which are useful in therapy, and to production of such polypeptides and polynucleotides.
Type:
Application
Filed:
May 20, 2002
Publication date:
September 25, 2003
Applicant:
Solvay Pharmaceuticals B.V.
Inventors:
Willy Deleersnijder, Rico Wiegers, Michael Weske
Abstract: The present invention relates, among many things, to novel 4,5-dihydro-1H-pyrazole compounds which can be potent antagonists of the cannabis CB1-receptor.
The compounds have the formula (I)
wherein
R and R1 are the same or different and represent unsubstituted or substituted phenyl, thienyl, or pyridyl, or naphthyl. naphthyl
R2 represents hydrogen, hydroxy, C1-3-alkoxy, acetyloxy or propionyloxy,
Aa represents one of the groups (i), (ii), (iii), (iv) or (v) as defined herein,
Bb represents sulfonyl or carbonyl, and
R3 represents benzyl, phenyl, thienyl or pyridyl, each of which is unsubstituted or substituted, or R3 represents C1-8 branched or unbranched alkyl or C3-8 cycloalkyl, or R3 represents naphthyl.
Type:
Grant
Filed:
March 23, 2001
Date of Patent:
November 5, 2002
Assignee:
Solvay Pharmaceuticals, B.V.
Inventors:
Josephus H. M. Lange, Cornelis G. Kruse, Jacobus Tipker, Martinus T. M. Tulp, Bernard J. Van Vliet
Abstract: The present invention relates, among many things, to novel 4,5-dihydro-1H-pyrazole compounds which can be potent antagonists of the cannabis CB1-receptor.
Type:
Application
Filed:
March 23, 2001
Publication date:
December 20, 2001
Applicant:
Solvay Pharmaceuticals B.V.
Inventors:
Josephus H. M. Lange, Cornelis G. Kruse, Jacobus Tipker, Martinus T. M. Tulp, Bernard J. Van Vliet