Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine-D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1): wherein the symbols have the meanings given in the specification.
Type:
Application
Filed:
December 6, 2005
Publication date:
June 21, 2007
Applicant:
SOLVAY PHARMECEUTICALS B.V.
Inventors:
Roelof Feenstra, Axel Stoit, Jan-Willem Terpstra, Maria Pras-Raves, Andrew McCreary, Bernard Van Vliet, Mayke Hesselink, Cornelis Kruse, Gustaaf Van Scharrenburg
Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine-D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1): wherein the symbols have the meanings given in the specification. and tautomers, stereoisomers and N-oxides thereof, as well as pharmacologically acceptable salts, hydrates and solvates of said compounds of formula (1) and its tautomers, stereoisomers and N-oxides.
Type:
Application
Filed:
December 6, 2005
Publication date:
March 29, 2007
Applicant:
SOLVAY PHARMECEUTICALS B.V.
Inventors:
Roelof Feenstra, Axel Stoit, Jan-Willem Terpstra, Maria Pras-Raves, Andrew McCreary, Bernard Van Vliet, Mayke Hesselink, Cornelis Kruse, Gustaaf Van Scharrenburg
Abstract: The present invention relates to a group of novel tetrahydropyridin-4-yl indoles with a dual mode of action: serotonin reuptake inhibition and affinity for dopamine-D2 receptors, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said tetrahydropyridin-4-yl indoles. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The invention relates to novel tetrahydropyridin-4-yl indoles of the formula.
Type:
Application
Filed:
December 6, 2005
Publication date:
March 22, 2007
Applicant:
SOLVAY PHARMECEUTICALS B.V.
Inventors:
Roelof van Hes, Pieter Smid, Cornelis Kruse, Martinus Tulp