Patents Assigned to Somatogenetics International, Inc.
  • Blood substitutes
    Patent number: 5028588
    Abstract: Solutions of mutant hemoglobins having a lower oxygen affinity than that of native hemoglobin are used as blood substitutes. The mutant hemoglobins are preferably obtained by recombinant DNA techniques. Both alpha and beta globin chains can now be so prepared, making possible the production of wholly artificial hemoglobin, whether conventional or mutant in form. Solutions of wholly artificial hemoglobins are also used as blood substitutes.
    Type: Grant
    Filed: May 16, 1988
    Date of Patent: July 2, 1991
    Assignee: Somatogenetics International, Inc.
    Inventors: Stephen L. Hoffman, Kiyoshi Nagai
  • Squalene oxide cyclase inhibitors and therapeutic use thereof
    Patent number: 4863932
    Abstract: Azadecalins and C-7 substituted decalins with squalene oxide cyclase inhibitory activity are useful as inhibitors of cholesterol synthesis and hence may be used in pharmaceuticals for regulating cholesterol levels in a mammal.
    Type: Grant
    Filed: March 11, 1988
    Date of Patent: September 5, 1989
    Assignees: Somatogenetics International, Inc., Dartmouth College
    Inventors: Michael Sinensky, Thomas A. Spencer