Abstract: The present technology relates to an information processing device, an information processing method, a program, and an information processing system for enabling reduction in a load by enabling selective arithmetic processing in performing imaging without using an imaging lens. The information processing device includes an acquisition unit configured to acquire a detection image output from an imaging element that receives incident light incident without through an imaging lens, and restoration information including setting information set by a user and to be used to generate a restoration image from the detection image, a restoration processing unit configured to perform restoration processing of generating the restoration image using the detection image and the restoration information, and an output control unit configured to control an output of the restoration image. The present technology can be applied to, for example, a device or a system that restores a detection image captured by a lensless camera.