Abstract: It is described a complex of riboflavin into hydroxypropylated ?-cyclodextrins as photosensitizer in the riboflavin-UV mediated cross-linking of corneal collage fibers and the relative ophthalmic compositions comprising it.

Abstract: It is described a complex of riboflavin into hydroxypropylated ?-cyclodextrins as photosensitizer in the riboflavin-UV mediated cross-linking of corneal collage fibers and the relative ophthalmic compositions comprising it.

Abstract: Ocular iontophoresis device and method for delivering any ionized drug solution to the cornea includes: a reservoir containing a solution suitable to be positioned on the eye; an active electrode disposed in or on the reservoir; and a passive electrode suitable to be placed on the skin of the subject, elsewhere on the body; elements for irradiating the cornea surface with suitable light for obtaining corneal cross-linking after the drug delivery; wherein the reservoir and the active electrode are transparent to UV light and/or visible light and/or IR light. The method includes: positioning the iontophoretic device on the eye to be treated; driving the solution by a cathodic current applied for 0.5 to 5 min, at an intensity not higher than 2 mA; and thereafter irradiating, with UV light for 5 to 30 min at a power of 3 to 30 mW/cm2; thereby obtaining the corneal cross-linking of the solution.

Abstract: An improved formulation of an ophthalmic composition contains riboflavin, as cross-linking agent of corneal collagen, administered by corneal iontophoresis, able to guarantee an increased capacity of permeation of riboflavin of the corneal stroma and therefore greater therapeutic efficacy in the treatment of keratoconus.

Abstract: A method of for prevention of presbyopia and glaucoma envisages stimulation of the ciliary body to determine contraction thereof via a low-voltage d.c. current sent in the form of pulse trains. This contraction, if applied in a rhythmic way at a constant frequency, subjects the ciliary muscle to a passive gymnastics increasing the force of contraction thereof, the dimensions, and the efficiency. This increase of force enables the crystalline to be moved with greater efficiency and consequently increases the power of accommodation thereof. The contraction of the ciliary muscle stretches the tendinous formation in direct contact with the sclero-corneal trabeculate and increases the distance between the lamellae of the sclero-corneal angle, restoring the natural function of the trabeculate and thus preventing glaucoma.

Abstract: Iontophoresis for delivering ophthalmic compositions (in particular. collyriums) preferably containing riboflavin, or other cross-linking agents, designed to imbibe the corneal stroma in the practice of the corneal collagen cross-linking (CXL) for the keratoconus treatment, and the corresponding ophthalmic compositions adapted to be administrated by iontophoresis in the treatment of keratoconus by corneal collagen cross-linking. Additionally, an ophthalmic composition for the treatment of keratoconus by corneal iontophoresis characterized by the fact that it includes cross-linking agents having buffering properties and whose initial pH value is included between 5 and 6, and/or bio-enhancers, and/or photo-enhancers.

Abstract: Ocular iontophoresis device and method for delivering any ionized drug solution to the cornea includes: a reservoir containing a solution suitable to be positioned on the eye; an active electrode disposed in or on the reservoir; and a passive electrode suitable to be placed on the skin of the subject, elsewhere on the body; elements for irradiating the cornea surface with suitable light for obtaining corneal cross-linking after the drug delivery; wherein the reservoir and the active electrode are transparent to UV light and/or visible light and/or IR light. The method includes: positioning the iontophoretic device on the eye to be treated; driving the solution by a cathodic current applied for 0.5 to 5 min, at an intensity not higher than 2 mA; and thereafter irradiating, with UV light for 5 to 30 min at a power of 3 to 30 mW/cm2; thereby obtaining the corneal cross-linking of the solution.

Abstract: The use of enhancers with possibly riboflavin, as well as the corresponding compositions for the treatment of keratoconus or other ectasic corneal disorders by the method of corneal cross-linking.

Abstract: A method of for prevention of presbyopia and glaucoma envisages stimulation of the ciliary body to determine contraction thereof via a low-voltage d.c. current sent in the form of pulse trains. This contraction, if applied in a rhythmic way at a constant frequency, subjects the ciliary muscle to a passive gymnastics increasing the force of contraction thereof, the dimensions, and the efficiency. This increase of force enables the crystalline to be moved with greater efficiency and consequently increases the power of accommodation thereof. The contraction of the ciliary muscle stretches the tendinous formation in direct contact with the sclero-corneal trabeculate and increases the distance between the lamellae of the sclero-corneal angle, restoring the natural function of the trabeculate and thus preventing glaucoma.