Abstract: A computer-implemented method for determining and quantifying modes of activation of biological pathways in individual cells, including: receiving sequencing data obtained by a single-cell RNA sequencing method, and a plurality of gene lists, determining a gene-cell expression matrix based on the sequencing data and the plurality of gene lists, carrying out a principal component analysis (PCA) on said gene-cell expression matrix, so as to determine a plurality of modes of activation of at least one among the biological pathways, selecting a subset of so-called effective modes of activation among the plurality of modes of activation, determining a matrix referred to as activity matrix, the activity matrix including scores quantifying a level of activity of each effective mode of activation among the subset of effective modes of activation within each individual cell among the set of individual cells.

Abstract: The invention relates to the use, as a herbicide, of at least one compound chosen from the compounds of general formula (I) and organic or inorganic salts thereof and isomers thereof. The invention also relates to a phytotoxic composition and to a method for controlling the development of and/or treating undesirable plants on the surface of a target zone.

Abstract: The invention relates to a method for determining at least one property of an object, the method comprising a step of: a) obtaining first data relative to the object by an ultrasound imaging technique imaging the object at a frame rate superior to 300 Hz, characterized in that the method further comprises a step of: b) obtaining second data relative to the object by imaging the object with at least one of a X-ray and a ?-ray, and c) determining the at least one property of the object based on the first data and the second data.

Abstract: A device for simulating a behavior of a mammal in an environment by a virtual mammal includes a mobile head and at least one mobile eye including a first input for successive data representative of eye poses, a second input for mobility action instructions, a memory for storing information on the environment and on stabilization constraints, at least one processor assessing a current part of the environment and recording information on said current part, triggering successive movements of the head and of the eye(s) in function of said mobility action, controlling a dynamic adjustment of the successive movements of the eye(s) with respect to the successive movements of the head in function of the successive data and by using the stabilization constraints. The device further comprises a third input for training data representative of a training movement sequence of the head and the eye(s) associated with a training environment.

Abstract: Electroacoustic device having a transducer including a piezoelectric substrate, first and second electrodes of inverse polarity having respective first and second tracks provided on said substrate, the first and second tracks spiraling around a same center (C), the transducer being configured for generating a swirling ultrasonic surface wave in the substrate.

Abstract: A Tamm electromagnetic cavity (10, 20, 30, 40, 60) possessing a resonant frequency in the THz domain, comprising: an interference mirror that is reflective in the THz domain, this mirror consisting of a stack of dielectric layers (7) comprising an alternation, in a z-direction, of two different layers, a layer referred to as the layer of high refractive index (2) and a layer referred to as the layer of low refractive index (4), the index of the layer of low refraction being lower than that of the layer of high refractive index, and being manufactured by stacking layers mechanically or by joining dielectric layers to one another; an upper metal layer (5) deposited on or added to an upper dielectric layer of said interference mirror so as to form a structure that supports at least one Tamm mode in the THz domain, the upper metal layer (5) being structured so as to form an antenna possessing a resonant frequency equal to that of the electromagnetic cavity.

Abstract: The present invention concerns a device for producing a “digital video classifier” configured to determine the quality of cleanliness of one or more segments of the digestive tube in a video capsule endoscopy (VCE) of a subject, comprising: a VCE allowing the acquisition of videos of segments of the digestive tube, video storage means, coupled with the VCE, an “image database” with images extracted from VCE exams, a “video database” with videos extracted from VCE exams, calculating means connected to the video storage means, and to the databases, and configured for performing a statistical learning for the generation of a “digital image classifier” from the “image database” and which classifies the images in adequate cleanliness or non-adequate cleanliness; generating the “digital video classifier” capable of classifying a video of a subject as being of adequate cleanliness or of non-adequate cleanliness of one or more segments of the digestive tube.

Abstract: The invention is in the field of therapy of antibody deficiencies. Inventors demonstrate for the first time in both controls and IgA-deficient patients. systemic anti-microbiota IgG responses correlate with reduced inflammation suggesting that systemic IgG responses contribute to the gut microbiota confinement. Furthermore. SIgAd-associated inflammation is inversely correlated with systemic anti-commensal IgG responses, which may thus serve as a second line of defense. Altogether, these data suggest that systemic IgG and intestinal IgA cooperate in different body compartments to limit systemic pro-inflammatory pathways. As selective IgA deficient patients harbour elevated seric anti-commensal IgG levels. these findings suggest that in selective IgA deficiency, microbiota confinement is obtained at the price of a strong inflammatory response. Accordingly. the invention relates to a composition containing immunoglobulins A (IgA). more particularly secretory IgA.

Abstract: The present invention relates to hybrid transcription regulatory elements to drive gene expression, in particular hybrid promoters, designed by the fusion of at least two transcription regulatory elements with different tissue selectivity, such as two promoters driving expression in different tissues in a tissue-selective manner.

Abstract: The invention concerns a multi-sensor brain detecting apparatus, the detecting apparatus being adapted to obtain two different physical values of a brain of a subject, the detecting apparatus comprising: a set of sensors comprising an ultrasound transducer adapted to produce ultrasound waves, a frame with a position with relation to the brain known with a stereotaxic precision, the frame being adapted to hold a sensor that can be positioned at a specific location by a user of the detecting apparatus without using a tool.

Abstract: A metasurface device includes a ground structure able to have a ground plane function, the ground structure being able to be alternately in an insulating state, wherein it prevents the propagation of the surface wave over the front surface of a substrate so as to prevent the antenna element from radiating, and in a conductive state, wherein the ground structure has the ground plane function, allowing the propagation of the surface wave over the front surface of the substrate from the emission/reception device to the conductive patches, or vice versa, the ground structure being able to change from the insulating state to the conductive state through illumination of the ground structure at a wavelength called a switching wavelength.

Abstract: Because of the increase of the obesity related diseases, it is desirable to be able to detect a fatty liver and quantify the content in fat for the fatty liver. Known methods are biopsy and magnetic resonance imaging. However, biopsy is an invasive method and magnetic resonance imaging is a complicated method to carry out. The inventors propose a new ultrasonic method, which is more compliant with a regular control of the content in fat for the fatty liver for a subject. This method notably relies on a smart exploitation of the coherence properties of ultrasound pulses applied to the liver. This method has already been validated on sane subjects as providing accurate measurements, notably for fat content.

Abstract: This system for real-time localization of a millimetric or submillimetric object, such as a microrobot, in a viscoelastic medium, in particular in an organ of a subject such as a brain, a liver or a pancreas, includes: at least one bubble configured to be attached to said object, the or each bubble having a hermetic envelope filled with a gas; at least one ultrasound transducer configured to emit initial ultrasound signals and to detect deflected ultrasound signals deflected at the surface of the bubble(s); a processing unit in communication with the ultrasound transducers and configured to generate localization data of the object from localization data of the bubble(s) based on the deflected ultrasound signals detected by the ultrasound transducers.

Abstract: The structure (10) comprises an elastically deformable body (12) defining at least one network of internal cavities (14), each internal cavity (14) having a closed contour in at least one section of the internal cavity (14). Each internal cavity (14) is able to be pressurized so as to make the elastically deformable body (12) pass from a rest configuration to at least one pressurized configuration. In each pressurized configuration, the elastically deformable body (12) has a macroscopic metric that is distinct from its macroscopic metric in the rest position. In each pressurized configuration, the radius of curvature of an outer surface of the elastically deformable body (12), considered regarding each internal cavity (14) adjacent to the outer surface, is greater than twice the size of the internal cavity (14) adjacent to the outer surface.

Abstract: A method for predicting the risk of prostate cancer recurrence in a subject affected with prostate cancer, including: (a) providing a sample from the subject, (b) determining the TMPRSS/ERG fusion status of the sample, (c) if the sample is positive for TMPRSS/ERG fusion (Fus+), determining a molecular signature of the sample by measuring the expression level of at least 6 prostate cancer markers selected from the ANPEP, AZGP1, CHRNA2, COMP, KHDRBS3 and SFRP4, (d) comparing the molecular signature to a reference signature, and (e) assigning the subject to a risk group based on the correlation of the molecular signature with the reference signature, thereby predicting the risk of cancer recurrence in the subject.

Abstract: A superconducting detection device for detecting a single microwave photon, including: —a quantum system with two energy levels of which the ground state and an excited state are controllable and detectable, the quantum system being designed to allow modulable three-wave interaction; —a buffer resonator arranged to receive an incident single microwave photon; —a highly dissipative auxiliary resonator arranged to discharge a photon; and —a reading device arranged to detect the state of the two-level quantum system; the buffer resonator and the auxiliary resonator are coupled to the quantum system; and the excited state of the quantum system and the photon of the auxiliary resonator are created in response to the reception of the incident photon in the buffer resonator and to the application of parametric pumping to the device. A method for detecting a single microwave photon implemented by a device according to the invention.

Abstract: The present invention concerns a reactor for the conversion of carbon dioxide or carbon monoxide into hydrocarbon and/or alcohol comprising a support made from an electrically and thermally conductive material, forming the wall or walls of at least one longitudinal channel that passes through the support and also acting as the cathode of the reactor, at least one wire electrode forming an anode of the reactor, and extending within each longitudinal channel, and being arranged at a distance from the wall or walls of the longitudinal channel, each wire electrode optionally being covered with an electrically insulating layer along the part of the wire electrode extending within the longitudinal channel, a catalyst capable of catalysing a conversion reaction for the conversion of carbon dioxide or carbon monoxide into hydrocarbon and/or alcohol, the catalyst being situated between the wire electrode and the wall or walls of each longitudinal channel.

Abstract: A method of diagnosing an MSI cancer in a patient including extracting and sequencing DNA from a tumoral sample and if available from a normal sample and operate an analyse of MNRs. The method is based on the demonstration that the FDA-approved NGS-based diagnostic test for identifying MSI in mCRC and nmCRC gave inaccurate results when compared with the gold standard reference methods. Consequently, whole exome sequencing (WES) data from all samples was further analyzed to improve detection of the MSI genomic signal in CRC and other primary tumor types. This allowed identification of weaknesses and limits of MSISensor and the design and validation of a newly optimized algorithm, namely MSICare. The high accuracy of MSICare for the detection of MSI in CRC and non-CRC tumors should allow it to become a future reference test for assessing MSI in pan-cancer.

Abstract: The invention relates to a recombinant adeno-associated virus (AAV) capsid protein, which is a hybrid between AAV serotype 9 (AAV9) and AAV serotype 74 (AAVrh74) capsid proteins, wherein said recombinant hybrid AAV capsid protein has a reduced liver tropism compared to the parent AAV9 and AAVrh74 capsid proteins. The invention relates also to the derived hybrid AAV serotype vector particles packaging a gene of interest and their use in gene therapy, in particular for treating neuromuscular genetic diseases.

Abstract: Systems, methods, and compositions relating to pretreatment and enzymatic degradation of polymeric materials comprising one or more crystallizable polymers or copolymers are generally described. Certain aspects are directed to methods comprising reacting a polymeric material comprising a crystallizable polymer or copolymer with a reactive agent to produce a pretreated polymeric material and exposing the pretreated polymeric material to a polymer-degrading enzyme. In some embodiments, the reactive agent induces chain extension, branching, and/or cross-linking of the crystallizable polymer or copolymer. In some embodiments, the reactive agent induces chain scissions followed by chain extension, branching, and/or cross-linking of the crystallizable polymer or copolymer.