Patents Assigned to SORBONNE UNIVERSITE
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Patent number: 12256992Abstract: Disclosed is a device including a detector producing a signal depending on variations of the pupil diameter of an eye of a subject, a display for presenting, to the subject, a light pattern subdivided into a plurality of regions, and an analyzer receiving the signal of the detector and analyzing the frequential content thereof. The display is controlled such that each region has a light intensity modulated at a respective modulation frequency, the modulation frequencies being different from one region to the next.Type: GrantFiled: July 16, 2019Date of Patent: March 25, 2025Assignees: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)Inventors: Jean Lorenceau, Suzon Ajasse
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Patent number: 12251451Abstract: The present description relates to an injectable emulsion comprising an amphiphilic compound, a first phase comprising droplets including at least one perfluorocarbon compound and a second phase, which is aqueous. The droplets have a diameter d4,3 of between 0.5 pm and 5.5 pm, and the at least one perfluorocarbon compound has a boiling point above 100° C. The present description also relates to methods comprising administering such an injectable emulsion in, for example, ultrasound ablation surgery (FIG. 3).Type: GrantFiled: June 14, 2019Date of Patent: March 18, 2025Assignees: Avignon Université, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, Sorbonne Université, UNIVERSITE DE MONTPELLIER, ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIERInventors: Christiane Contino-Pepin, Stéphane Desgranges, Nicolas Taulier
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Patent number: 12251258Abstract: Disclosed is a method for characterising an object, comprising: emission of ultrasonic waves that enter an object by passing through an external interface, then reflect off an internal interface, then exit the object by passing through the external interface again, the ultrasonic waves comprising first waves having a mode that varies according to a first variation during their propagation in the object, and second waves having a mode that varies according to a second variation during their propagation in the object; reception of echo signals comprising first signals representing echoes of the first waves, and second signals representing echoes of the second waves, construction of a plurality of images showing the object, the plurality of images being constructed from the echo signals, under the assumption that two characteristics of the object are equal to two candidate values, and comprising a first image constructed from the first signals, and a second constructed from the second signals; construction of aType: GrantFiled: April 26, 2021Date of Patent: March 18, 2025Assignees: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALEInventor: Guillaume Renaud
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Patent number: 12248202Abstract: The invention relates to filter dedicated to protect eye cone cells and method associated. The eye cone cells protecting filter is intended to be applied to a transparent surface and to filter incident light for preventing eye cone cells of a user, from damages due to illumination at physiological light levels on the eye of said user, and having spectral characteristics to i) filter light wavelengths between 405 and 465 nanometers, and ii) transmit a filtered light reaching the eye cone cells and having a harmfulness on said eye cone cells under a predefined maximum threshold.Type: GrantFiled: March 13, 2020Date of Patent: March 11, 2025Assignees: Essilor International, Sorbonne UniversitéInventors: Mélanie Marie, Serge Picaud, Valérie Fradot, José Sahel, Thierry Villette, Coralie Barrau, Camille Ehrismann
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Publication number: 20250040942Abstract: A medical device for penetrating an anatomic structure, e.g., a bone structure, including a processing unit programmed to execute one or more statistical algorithms, e.g., Bayesian-based perforation detection algorithms, with electrical conductivity measured during penetration of an anatomic structure as an input to detect a breach condition, e.g., a spinal canal perforation, based on the measured electrical conductivity. The medical device may include a drill bit having sensing capabilities coupled to the distal end of a robot arm via a power drill unit mounted on the robot arm. The power drill unit may cease transmission of rotary motion to the drill bit upon detection of the breach condition.Type: ApplicationFiled: July 25, 2024Publication date: February 6, 2025Applicants: SpineGuard, Sorbonne Universite, Centre National De La Recherche Scientifique-CNRS, INSERM (Institut National de la Sante et de la Recherche Medicale)Inventors: Lilyan LEBLANC, Brahim TAMADAZTE, Thibault CHANDANSON, Elie SAGHBINY
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Patent number: 12215067Abstract: Disclosed is chemical compounds C that are derivatives of norbixin and have tropism for the eye, and are intended to be used in the treatment of eye diseases in mammals, in particular in the context of altering the retinal pigment epithelium and more particularly in the context of age-related macular degeneration (AMD) and Stargardt's disease.Type: GrantFiled: December 22, 2020Date of Patent: February 4, 2025Assignees: BIOPHYTIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), SORBONNE UNIVERSITEInventors: Laurence Dinan, René Lafont, Pierre Dilda, Serge Camelo, Valérie Fontaine, Christine Balducci, Elodie Monteiro, Louis Guibout, Mathilde Latil, José-Alain Sahel, Stanislas Veillet
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Publication number: 20250029678Abstract: A computer-implemented method for determining and quantifying modes of activation of biological pathways in individual cells, including: receiving sequencing data obtained by a single-cell RNA sequencing method, and a plurality of gene lists, determining a gene-cell expression matrix based on the sequencing data and the plurality of gene lists, carrying out a principal component analysis (PCA) on said gene-cell expression matrix, so as to determine a plurality of modes of activation of at least one among the biological pathways, selecting a subset of so-called effective modes of activation among the plurality of modes of activation, determining a matrix referred to as activity matrix, the activity matrix including scores quantifying a level of activity of each effective mode of activation among the subset of effective modes of activation within each individual cell among the set of individual cells.Type: ApplicationFiled: July 20, 2023Publication date: January 23, 2025Applicants: One Biosciences, Centre National de la Recherche Scientifique, Institut CURIE, Sorbonne UniversitéInventors: Céline VALLOT, Yuna LANDAIS
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Patent number: 12193443Abstract: The invention relates to the use, as a herbicide, of at least one compound chosen from the compounds of general formula (I) and organic or inorganic salts thereof and isomers thereof. The invention also relates to a phytotoxic composition and to a method for controlling the development of and/or treating undesirable plants on the surface of a target zone.Type: GrantFiled: March 16, 2020Date of Patent: January 14, 2025Assignees: ECOLE POLYTECHNIQUE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITEInventors: Bastien Nay, Emmanuel Baudouin, Wei Zhang
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Patent number: 12193864Abstract: The invention relates to a method for determining at least one property of an object, the method comprising a step of: a) obtaining first data relative to the object by an ultrasound imaging technique imaging the object at a frame rate superior to 300 Hz, characterized in that the method further comprises a step of: b) obtaining second data relative to the object by imaging the object with at least one of a X-ray and a ?-ray, and c) determining the at least one property of the object based on the first data and the second data.Type: GrantFiled: June 7, 2023Date of Patent: January 14, 2025Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, SORBONNE UNIVERSITE, UNIVERSITÉ PARIS CITÉ, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, ASSISTANCE PUBLIQUE—HOPITAUX DE PARISInventors: Jean Provost, Anikitos Garofalakis, Mathieu Pernot, Mickaël Tanter, Bertrand Tavitian, Thomas Viel
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Patent number: 12198573Abstract: A device for simulating a behavior of a mammal in an environment by a virtual mammal includes a mobile head and at least one mobile eye including a first input for successive data representative of eye poses, a second input for mobility action instructions, a memory for storing information on the environment and on stabilization constraints, at least one processor assessing a current part of the environment and recording information on said current part, triggering successive movements of the head and of the eye(s) in function of said mobility action, controlling a dynamic adjustment of the successive movements of the eye(s) with respect to the successive movements of the head in function of the successive data and by using the stabilization constraints. The device further comprises a third input for training data representative of a training movement sequence of the head and the eye(s) associated with a training environment.Type: GrantFiled: March 20, 2020Date of Patent: January 14, 2025Assignees: Essilor International, Sorbonne UniversitéInventors: Denis Sheynikhovich, Richard Carrillo, Luca Leonardo Bologna, Youssouf Cherifi, Tianyi Li, Angelo Arleo, Konogan Baranton, Anne-Catherine Scherlen, Delphine Tranvouez-Bernardin
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Patent number: 12179192Abstract: Electroacoustic device having a transducer including a piezoelectric substrate, first and second electrodes of inverse polarity having respective first and second tracks provided on said substrate, the first and second tracks spiraling around a same center (C), the transducer being configured for generating a swirling ultrasonic surface wave in the substrate.Type: GrantFiled: June 16, 2023Date of Patent: December 31, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE LILLE, ECOLE CENTRALE DE LILLE, SORBONNE UNIVERSITEInventors: Michaël Aymeric Baudoin, Olivier Khalil Nizar Bou Matar-Lacaze, Antoine Jean-Pierre Riaud, Jean-Louis Pierre Thomas
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Patent number: 12181694Abstract: A Tamm electromagnetic cavity (10, 20, 30, 40, 60) possessing a resonant frequency in the THz domain, comprising: an interference mirror that is reflective in the THz domain, this mirror consisting of a stack of dielectric layers (7) comprising an alternation, in a z-direction, of two different layers, a layer referred to as the layer of high refractive index (2) and a layer referred to as the layer of low refractive index (4), the index of the layer of low refraction being lower than that of the layer of high refractive index, and being manufactured by stacking layers mechanically or by joining dielectric layers to one another; an upper metal layer (5) deposited on or added to an upper dielectric layer of said interference mirror so as to form a structure that supports at least one Tamm mode in the THz domain, the upper metal layer (5) being structured so as to form an antenna possessing a resonant frequency equal to that of the electromagnetic cavity.Type: GrantFiled: April 3, 2020Date of Patent: December 31, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1, SORBONNE UNIVERSITE, ECOLE NORMALE SUPERIEURE DE PARIS, UNIVERSITE DE PARISInventors: Juliette Mangeney, Sukhdeep Dhillon, Clémentine Symonds, Joël Bellessa, Simon Messelot
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Patent number: 12175663Abstract: The present invention concerns a device for producing a “digital video classifier” configured to determine the quality of cleanliness of one or more segments of the digestive tube in a video capsule endoscopy (VCE) of a subject, comprising: a VCE allowing the acquisition of videos of segments of the digestive tube, video storage means, coupled with the VCE, an “image database” with images extracted from VCE exams, a “video database” with videos extracted from VCE exams, calculating means connected to the video storage means, and to the databases, and configured for performing a statistical learning for the generation of a “digital image classifier” from the “image database” and which classifies the images in adequate cleanliness or non-adequate cleanliness; generating the “digital video classifier” capable of classifying a video of a subject as being of adequate cleanliness or of non-adequate cleanliness of one or more segments of the digestive tube.Type: GrantFiled: September 28, 2021Date of Patent: December 24, 2024Assignees: ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ÉCOLE NATIONALE SUPÉRIEURE DE L'ELECTRONIQUE ET DE SES APPLICATIONS, CY CERGY PARIS UNIVERSITEInventors: Marc Souchaud, Aymeric Histace, Romain Leenhardt, Xavier Dray
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Patent number: 12173053Abstract: The invention is in the field of therapy of antibody deficiencies. Inventors demonstrate for the first time in both controls and IgA-deficient patients. systemic anti-microbiota IgG responses correlate with reduced inflammation suggesting that systemic IgG responses contribute to the gut microbiota confinement. Furthermore. SIgAd-associated inflammation is inversely correlated with systemic anti-commensal IgG responses, which may thus serve as a second line of defense. Altogether, these data suggest that systemic IgG and intestinal IgA cooperate in different body compartments to limit systemic pro-inflammatory pathways. As selective IgA deficient patients harbour elevated seric anti-commensal IgG levels. these findings suggest that in selective IgA deficiency, microbiota confinement is obtained at the price of a strong inflammatory response. Accordingly. the invention relates to a composition containing immunoglobulins A (IgA). more particularly secretory IgA.Type: GrantFiled: June 19, 2023Date of Patent: December 24, 2024Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Sorbonne Université, Assistance Publique-Hôpitaux de Paris (APHP)Inventors: Guy Gorochov, Martin Larsen, Delphine Sterlin, Jehane Fadlallah
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Patent number: 12171843Abstract: The present invention relates to hybrid transcription regulatory elements to drive gene expression, in particular hybrid promoters, designed by the fusion of at least two transcription regulatory elements with different tissue selectivity, such as two promoters driving expression in different tissues in a tissue-selective manner.Type: GrantFiled: February 7, 2019Date of Patent: December 24, 2024Assignees: GENETHON, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM), SORBONNE UNIVERSITÉ, UNIVERSITE D'EVRY VAL D'ESSONNE, ASSOCIATION INSTITUT DE MYOLOGIEInventors: Federico Mingozzi, Pasqualina Colella
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Patent number: 12138118Abstract: The invention concerns a multi-sensor brain detecting apparatus, the detecting apparatus being adapted to obtain two different physical values of a brain of a subject, the detecting apparatus comprising: a set of sensors comprising an ultrasound transducer adapted to produce ultrasound waves, a frame with a position with relation to the brain known with a stereotaxic precision, the frame being adapted to hold a sensor that can be positioned at a specific location by a user of the detecting apparatus without using a tool.Type: GrantFiled: October 21, 2021Date of Patent: November 12, 2024Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, SORBONNE UNIVERSITÉ, UNIVERSITÉ PARIS CITÉ, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARISInventors: Jean-Luc Gennisson, Mickaël Tanter, Thomas Deffieux, Mathieu Pernot
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Patent number: 12142832Abstract: A metasurface device includes a ground structure able to have a ground plane function, the ground structure being able to be alternately in an insulating state, wherein it prevents the propagation of the surface wave over the front surface of a substrate so as to prevent the antenna element from radiating, and in a conductive state, wherein the ground structure has the ground plane function, allowing the propagation of the surface wave over the front surface of the substrate from the emission/reception device to the conductive patches, or vice versa, the ground structure being able to change from the insulating state to the conductive state through illumination of the ground structure at a wavelength called a switching wavelength.Type: GrantFiled: July 20, 2021Date of Patent: November 12, 2024Assignees: ULTIMETAS, PARIS SCIENCES ET LETTRES, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITEInventors: Jean Chazelas, Charlotte Tripon-Canseliet
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Patent number: 12138111Abstract: Because of the increase of the obesity related diseases, it is desirable to be able to detect a fatty liver and quantify the content in fat for the fatty liver. Known methods are biopsy and magnetic resonance imaging. However, biopsy is an invasive method and magnetic resonance imaging is a complicated method to carry out. The inventors propose a new ultrasonic method, which is more compliant with a regular control of the content in fat for the fatty liver for a subject. This method notably relies on a smart exploitation of the coherence properties of ultrasound pulses applied to the liver. This method has already been validated on sane subjects as providing accurate measurements, notably for fat content.Type: GrantFiled: September 25, 2020Date of Patent: November 12, 2024Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITÉ PARIS CITÉ, SORBONNE UNIVERSITÉ, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARISInventors: Mathieu Pernot, Thomas Deffieux, Mickael Tanter, Clément Papadacci
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Patent number: 12133767Abstract: This system for real-time localization of a millimetric or submillimetric object, such as a microrobot, in a viscoelastic medium, in particular in an organ of a subject such as a brain, a liver or a pancreas, includes: at least one bubble configured to be attached to said object, the or each bubble having a hermetic envelope filled with a gas; at least one ultrasound transducer configured to emit initial ultrasound signals and to detect deflected ultrasound signals deflected at the surface of the bubble(s); a processing unit in communication with the ultrasound transducers and configured to generate localization data of the object from localization data of the bubble(s) based on the deflected ultrasound signals detected by the ultrasound transducers.Type: GrantFiled: November 14, 2019Date of Patent: November 5, 2024Assignees: ROBEAUTE, SORBONNE UNIVERSITÉ, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Bertrand Duplat, Quentin Francois, Sinan Haliyo, Régis Marchiano, Stéphane Regnier
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Patent number: 12129907Abstract: The structure (10) comprises an elastically deformable body (12) defining at least one network of internal cavities (14), each internal cavity (14) having a closed contour in at least one section of the internal cavity (14). Each internal cavity (14) is able to be pressurized so as to make the elastically deformable body (12) pass from a rest configuration to at least one pressurized configuration. In each pressurized configuration, the elastically deformable body (12) has a macroscopic metric that is distinct from its macroscopic metric in the rest position. In each pressurized configuration, the radius of curvature of an outer surface of the elastically deformable body (12), considered regarding each internal cavity (14) adjacent to the outer surface, is greater than twice the size of the internal cavity (14) adjacent to the outer surface.Type: GrantFiled: July 22, 2019Date of Patent: October 29, 2024Assignees: PARIS SCIENCES ET LETTRES—QUARTIER LATIN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, SORBONNE UNIVERSITÉ, UNIVERSITÉ DE PARISInventors: Emmanuel Siefert, Benoît Roman, José Bico, Etienne Reyssat