Patents Assigned to SORBONNE UNIVERSITE
  • Patent number: 11905330
    Abstract: Autophagy is typically activated by starvation, allowing cells and organisms to mobilize their energy reserves. It is known that pharmacological modulation of autophagy represents a therapeutic potential. Here the inventors report that a protein that is released from cells in an unconventional, autophagy-dependent manner, namely, diazepam binding inhibitor (DBI), regulates autophagy. In particular, the inventors demonstrate that DBI inhibits autophagy and that the supply of recombinant DBI to mice enhanced glycolysis, enhanced lipogenesis, and inhibited fatty acid oxidation. The inventors show that neutralisation of DBI by a monoclonal antibody and an active immunization by means of an immunogenic DBI derivative eliciting autoantibodies induce autophagy and lead to metabolic changes that increase starvation-induced weight loss, reduce food intake upon refeeding, and reduce weight gain in response to hypercaloric diets.
    Type: Grant
    Filed: September 26, 2022
    Date of Patent: February 20, 2024
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP), UNIVERSITÉ PARIS CITÉ, SORBONNE UNIVERSITÉ
    Inventors: Guido Kroemer, José Manuel Bravo San Pedro
  • Patent number: 11903382
    Abstract: Disclosed is a device for the perfusion of an organ, including: a container of fluid, containing an organ bathed in the perfusion fluid; a first path including an inlet, an outlet and a pump; and a second path including an inlet, an outlet and a pump. The “arterial” outlet of the first path has a diameter smaller than a diameter of the “portal” outlet of the second path. The device additionally includes, between the pump and the outlet of the first path and/or between the pump and the outlet of the second path, an oxygenation unit arranged to oxygenate the fluid emerging from the “arterial” outlet of the first path more than the fluid emerging from the “portal” outlet of the second path. The device can include a communication path between the first path and the second path in order to oxygenate the second path. Use in liver transplantation.
    Type: Grant
    Filed: January 11, 2023
    Date of Patent: February 20, 2024
    Assignees: UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS
    Inventors: Cécile Legallais, Patrick Paullier, Olivier Scatton, Eric Savier
  • Publication number: 20240053345
    Abstract: The present invention relates to a polypeptide X1X2-RK-X3X4-KK-X5X6X7X8X9X10-KR-X11X12 SEQ ID NO: 1 able to bind selectively to cells expressing proteoglycans comprising glycosaminoglycans as heparin or heparan sulfate. The linkage of said polypeptide to an internalization peptide enables the polypeptide to be internalized. The present invention further relates to a conjugated polypeptide comprising said polypeptide and a biomarker, to a cell penetrating polypeptide comprising said polypeptide, optionally a linker and a cell internalization peptide and a chimeric polypeptide comprising said cell penetrating polypeptide and one or more biological cargos.
    Type: Application
    Filed: December 17, 2020
    Publication date: February 15, 2024
    Applicants: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), COLLEGE DE FRANCE
    Inventors: Sandrine Sagan, Alain Joliot, Astrid Walrant, Ludovic Carlier, Sébastien Cardon
  • Publication number: 20240041423
    Abstract: A device tracking system for monitoring a target body structure and localizing a device inside the target body structure. The device tracking system includes: a control unit, a device having one steering element to be handled outside the target body structure and one steerable element to be introduced inside the target body structure, one probe to be removably secured to the patient, and one tracker to be secured to the steerable element. The control unit stores one ultrasound image of the target body structure. The probe and the tracker communicate, and the control unit is able to localize, in real time, the steerable element. The control unit displays, the stored ultrasound image and displays, in real time, the localisation of the at steerable element on the at least one ultrasound image.
    Type: Application
    Filed: December 10, 2021
    Publication date: February 8, 2024
    Applicants: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
    Inventors: Antoine COUDERT, Olivier COUTURE, Vincent HINGOT
  • Patent number: 11872413
    Abstract: The present invention relates to a method for controlling a probe for the treatment of brain tissue using an assembly comprising the probe and an acoustic window (1), the probe (2) including a plurality of transducers (21) for generating ultrasound waves, the method comprising: —a phase of detection: •of the probe transducers situated above the cranium (4) of the patient, and •of the probe transducers situated above the acoustic window (1), so as to permit: •deactivation of the transducers situated above the cranium (4) of the patient, •activation of the transducers situated above the acoustic window (1).
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: January 16, 2024
    Assignees: ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, SORBONNE UNIVERSITE, CARTHERA
    Inventors: Alexandre Carpentier, Guillaume Bouchoux, Michael Canney, Francois Lacoste
  • Patent number: 11865189
    Abstract: The present invention relates to methods and composition for use in the treatment of retinal degeneration, in particular retinal degeneration due to retinal pigment epithelium dysfunction.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: January 9, 2024
    Assignees: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Thierry Leveillard, Christo Kole, Jose-Alain Sahel
  • Publication number: 20240002776
    Abstract: The present invention relates to a device (2) for providing a liquid medium with a controlled flow rate and with a controlled concentration of a dissolved gas, the device (2) comprising: —a liquid reservoir (4) provided with: —at least one gas inlet (7); —at least one gas outlet (8); and—at least one liquid outlet (9); —an admission line (5) configured to provide a gaseous medium into the liquid reservoir (4), the admission line (5) being connected to the at least one gas inlet (7) and comprising at least one control valve (12); and an emission line (6) configured to withdraw the gaseous medium from the liquid reservoir (4), the emission line (6) being connected to the at least one gas outlet (8) and comprising at least one control valve (15). The present invention further relates to an assembly comprising said device, and to a method for providing a liquid medium with a controlled flow rate and with a controlled concentration in a dissolved gas.
    Type: Application
    Filed: September 30, 2021
    Publication date: January 4, 2024
    Applicants: Sorbonne Universite, Centre National De La Recherche Scientifique, Institut Curie, Fluigent
    Inventors: William Cesar, Charlotte Bouquerel, Marine Verhulsel, Jean-Louis Viovy, Stéphanie Descroix
  • Patent number: 11857254
    Abstract: The invention relates to a method for characterizing a visual system of a subject using measures of the sensitivity to contrast, the visual system comprising visual signal processing elements each having an impact on the sensitivity to contrast, wherein a visual test where visual patterns having different spatiotemporal frequencies and with varying luminance levels and with varying levels of visual degradation of the visual patterns are shown to a subject to measure the sensitivity to contrast of said subject, is performed, wherein a predetermined response model of a visual system is preestablished on the basis of a determination of the visual signal processing element that predominantly limits the sensitivity to contrast for each value of luminance and spatiotemporal frequency, said predetermined response model relating the visual signal processing elements predominantly limiting the sensitivity to contrast to the luminances and to the spatiotemporal frequencies, wherein at least one of the visual signal pro
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: January 2, 2024
    Assignees: Essilor International, Sorbonne Université
    Inventors: Rémy Allard, Daphné Silvestre
  • Patent number: 11854801
    Abstract: A method for depositing an object, including: —approaching, in an enclosure, a holder in the direction of a carrier substrate, then—transferring, in the enclosure, the object from the holder to an area for depositing the carrier substrate. The transfer step is preferably carried out when the inside of the enclosure is in a vacuum at a pressure below 10?6 bar.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: December 26, 2023
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE, SORBONNE UNIVERSITE, UNIVERSITE DE PARIS
    Inventors: Matthieu Delbecq, Tino Cubaynes, José Palomo, Matthieu Dartiailh, Takis Kontos, Matthieu Desjardins
  • Patent number: 11849958
    Abstract: The present invention relates to a surgical kit for use in a craniectomy procedure, the surgical kit comprising: a medical device to be implanted in a cranial bone of a patient, the medical device (10) including several transducers for emitting ultrasound waves for treatment of brain tissue, a surgical accessory (20) intended to be positioned on the cranial bone of the patient, the surgical accessory (20) including a body whose outer perimeter defines the dimensions of an opening that is to be made in the cranial bone of the patient in order to receive the medical device, characterized in that the surgical accessory (20) comprises a plurality of holes (201) formed in the body, the position of each hole (201) on the body coinciding with the position of the axis of symmetry of a respective transducer, such that the accessory is able to be positioned optimally through the joint use of a neuronavigation system.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: December 26, 2023
    Assignees: ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, SORBONNE UNIVERSITE, CARTHERA
    Inventors: Alexandre Carpentier, Alexandre Vignot, Matthieu Cholvy
  • Patent number: 11819492
    Abstract: The present invention relates to a compound of the following general formula (I): or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug, particularly intended for inhibiting a programmed cell death route selected from the group consisting of ferroptosis, oxytosis and cellular necroptosis. The present invention also relates to a compound of general formula (I) for use as a drug for neuroprotection as well as for preventing and/or treating disorders associated with cellular necroptosis or ferroptosis. The present invention also relates to a pharmaceutical composition comprising a compound of general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: November 21, 2023
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite, Universite de Poitiers, Centre Hospitalier Universitaire de Poitiers
    Inventors: Stéphane Bach, Marie-Thérèse Dimanche-Boitrel, Claire Delehouze, Thierry Hauet
  • Patent number: 11808627
    Abstract: A photoconductive switch for generating or detecting terahertz radiation (TR) is provided. The photoconductive switch may comprise at least a first and a second pair of electrodes (EV, EH, EGR) on a surface (SS) of a photoconductive substrate, wherein the electrodes of the first pair are separated by a first gap comprising at least a plurality of first rectilinear sections (GV) extending along a first direction (x) and the electrodes of the second pairs are separated by a second gap comprising at least a plurality of second sections (GH) extending along a second direction (y), different from the first direction. The photoconductive switch may further comprise a patterned opaque layer (PML) selectively masking portions of the gaps between the electrodes. Methods and devices for generating and detecting terahertz radiation comprising such photoconductive switches are also provided.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: November 7, 2023
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE, ECOLE NORMALE SUPERIEURE DE PARIS, UNIVERSITÉ PARIS CITÉ
    Inventors: Kenneth Maussang, Sukhdeep Dhillon, Jerome Tignon
  • Patent number: 11803014
    Abstract: Optical system comprising two optical fibres which are configured to define between them a Fabry-Perot cavity, and a connecting element bonded to each of the two optical fibres, the connecting element defining a through-passage, at least one of the two optical fibres comprising an end portion arranged in the through-passage and bonded to the connecting element, the two optical fibres extending along an axis and being separated from one another by a distance Le parallel to the axis, one of the optical fibres being bonded to the connecting element at a first bonding zone, and the other optical fibre being bonded to the connecting element at a second bonding zone separated from the first bonding zone by distance parallel to the axis.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: October 31, 2023
    Assignees: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE
    Inventors: Jakob Reichel, Romain Long
  • Publication number: 20230330440
    Abstract: Devices and methods for reversibly stimulating neuronal cells in a subject. The devices include a module for generating ultrasounds at 4 MHz or more to stimulate neuronal cells expressing mechanosensitive channels with the ultrasounds. The methods include expressing mechanosensitive channels into neuronal cells and exposing the cells to ultrasounds at 4 MHz or more. Also, the use of the methods or devices for visual restoration in a subject.
    Type: Application
    Filed: September 9, 2021
    Publication date: October 19, 2023
    Applicants: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
    Inventors: Serge PICAUD, Sara CADONI, José-Alain SAHEL, Mickaël TANTER, Charlie DEMENE
  • Patent number: 11771925
    Abstract: An implantable ultrasound generating treating device (12) to induce spinal cord or spinal nerves treatment, suitable for implantation in the spinal canal and comprises an elongate support member (22, 32) and an array of several treatment transducers (20) distributed along the elongate support member. The several treatment transducers (20) comprise radial transducers emitting an ultrasound treatment beam oriented radially, wherein the treatment transducers (20) have a resonant frequency comprised between 0.5 and 4 MHz. The device has articulating portions so that the implantable device can adapt its shape to a curved elongation path. Also disclosed is an apparatus including the implantable ultrasound generating treating device and methods comprising inserting the implantable ultrasound generating treating device (12) inside the spinal canal of the spine of the patient.
    Type: Grant
    Filed: July 18, 2022
    Date of Patent: October 3, 2023
    Assignees: SORBONNE UNIVERSITE, ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS
    Inventor: Alexandre Carpentier
  • Publication number: 20230293490
    Abstract: Disclosed are anti-angiogenic agents that target Pfn1:actin interaction. Also disclosed are compounds for treating ocular diseases or conditions. Further disclosed are compounds for treating cancer.
    Type: Application
    Filed: August 12, 2021
    Publication date: September 21, 2023
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Sorbonne Université, Centre National de la Recherche Scientifique, INSERM (Institut de la Sante er de la Recherche Medicale)
    Inventors: Partha Roy, Lee McDermott, Abigail E. Allen, David Koes, David M. Gau, Paul G. Francoeur, Xavier Guillonneau
  • Patent number: 11757168
    Abstract: A method for manufacturing a superconducting LC-type resonator of the type including at least one high-resistivity substrate on which are printed an inductive meander, a first so-called lower electrode and a second so-called upper electrode arranged opposite the first so as to form together a capacitor connected in parallel with the inductive meander, as well as inductive coupling means dedicated to the resonator, in which a sacrificial aluminium layer is deposited between the first and second electrodes. Also disclosed is the superconducting LC-type resonator thus obtained and the use of such a resonator for detecting the noise of a millimetre photon.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: September 12, 2023
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, OBSERVATOIRE DE PARIS, CY CERGY PARIS UNIVERSITÉ, SORBONNE UNIVERSITE, UNIVERSITÉ DE PARIS
    Inventors: Faouzi Boussaha, Samir Beldi, Christine Chaumont, Thibaut Vacelet
  • Publication number: 20230279422
    Abstract: The use of recombinant AAV vectors expressing a molecule of interest in a method for treating diseases or conditions affecting the nervous system in a subject in need thereof, or in a method for increasing or inducing expression of the molecule of interest in the nervous system of a subject.
    Type: Application
    Filed: May 20, 2022
    Publication date: September 7, 2023
    Applicants: ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE), INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCH MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS), SORBONNE UNIVERSITE
    Inventors: Françoise PIGUET, Caroline SEVIN
  • Patent number: 11738214
    Abstract: An apparatus having an implantable ultrasound generating treating device to induce brain disorder treatment, suitable for implantation in or under the skull bone of a patient, includes several ultrasound generating transducers, which are connectable by a common electrical connection circuit to a generator, and wherein the ultrasound generating transducers each have one or several operating frequencies. The transducers include the group of transducers having several transducers driven by a same electrical drive signal, and connected to the generator system by a common electrical connection circuit, where the electric drive signal serves both as power signal and as a control signal for operating selectively, within said group, at least one or the other of a first transducer or sub-group of transducers, and of a second transducer or sub-group of transducers. The apparatus is also used to treat brain disorders.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: August 29, 2023
    Assignees: SORBONNE UNIVERSITE, ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS, CARTHERA
    Inventors: Alexandre Carpentier, Michael Canney, Matthieu Cholvy
  • Patent number: 11731127
    Abstract: Electroacoustic device having a transducer including a piezoelectric substrate, first and second electrodes of inverse polarity having respective first and second tracks provided on said substrate, the first and second tracks spiraling around a same center (C), the transducer being configured for generating a swirling ultrasonic surface wave in the substrate.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: August 22, 2023
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE LILLE, ECOLE CENTRALE DE LILLE, SORBONNE UNIVERSITE
    Inventors: Michaël Aymeric Baudoin, Olivier Khalil Bou Matar-Lacaze, Antoine Jean-Pierre Riaud, Jean-Louis Pierre Thomas