Abstract: A glucose sensor assembly useful in patient systems includes an oxygen sensor from which glucose levels in the vicinity of the peritoneal cavity may be inferred. The sensor assembly may be associated with electronics, such as any or all of a DC power supply, an LED source of blue light, a photoreceptor for red light, a CPU, and transceiver, by a direct percutaneous connection. Alternatively they may be associated transdermally with the sensor and some of the electronics being located subdurally. Insulin infusion means are contemplated to respond manually or mechanically to information from the sensors through the CPU. Mechanical response may be automatic. Infusion means may be located subdurally. It is contemplated that the present invention enable revitalization or replacement of fluorescing compounds and glucose oxidase within the sensor assembly.

Abstract: An implantable biosensor assembly and system includes an enzymatic sensor probe from which subcutaneous and interstitial glucose levels may be inferred. The assembly may be associated by direct percutaneous connection with electronics, such as for signal amplification, sensor polarization, and data download, manipulation, display, and storage. The biosensor comprises a miniature probe characterized by lateral flexibility and tensile strength and has large electrode surface area for increased sensitivity. Irritation of tissues surrounding the probe is minimized due to ease of flexibility and small cross section of the sensor. Foreign body reaction is diminished due to a microscopically rough porous probe surface.

Abstract: A manifold assembly useful in patient ventilation/aspiration systems includes a stop cock valve with a hollow stem and a transverse slot arranged to permit the stem to be rotated between open and closed positions. In both positions, a ventilating pathway is maintained through the slot and the stem between ventilator and patient connection ports of the manifold. In open position the stem provides a travel pathway for a catheter between the patient connection port and an access port of the manifold. In closed condition, the stem seals this travel pathway. Catheter depth finding features and internally walled manifold structure for direction of respiratory therapy fluids particularly useful for neonatal patients are presented.