Patents Assigned to Sorin CRM SAS
  • Patent number: 10314613
    Abstract: An explantation accessory includes a catheter with a steerable head carrying a tubular receptacle adapted to accommodate the proximal portion of the capsule. The explantation accessory further includes a lasso having a flexible wire extending along the catheter to and forming at its distal end a deformable loop. One end of the deformable loop is mobile so as to allow tightening of the loop under the effect of a traction exerted on the flexible wire along the catheter. The free end edge of the tubular receptacle comprises a protruding anterior portion, an axially recessed posterior portion with respect to the anterior portion and located diametrically opposite to the protruding anterior portion, and two beveled edges connecting the protruding anterior portion to the recessed posterior portion.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: June 11, 2019
    Assignee: Sorin CRM SAS
    Inventors: Jean-François Ollivier, Nicolas Shan, Philippe D'hiver
  • Publication number: 20190167138
    Abstract: A lead for active implantable medical devices comprising a chip, notably for electrode multiplexing. The lead includes an insulating supporting tube interposed in a flexible elongated tube, with a central bore coaxial with the lumen of the lead. The supporting tube comprises on its surface at least one crossing conductive strip extending in the axial direction. A chip on a flexible substrate is disposed with a bent or curved conformation in a receptacle of the supporting tube isolated from the conductive strip. An electrode, e.g., for cardiac sensing/pacing, carried by the supporting tube is electrically connected to an outer conductive pad of the chip. The conductive strip is connected (i) at each end, face to face to a conductive connection, housed in the sheath, and (ii) in a central region, to an inner conductive pad of the chip.
    Type: Application
    Filed: January 18, 2019
    Publication date: June 6, 2019
    Applicant: SORIN CRM SAS
    Inventor: Jean-François Ollivier
  • Patent number: 10307328
    Abstract: A device for treating sleep apnea by discriminating between successive sleep stages of a patient includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, a sensor configured to measure a biological parameter of the patient, and a controller. The controller is configured to determine a state of the patient based on the biological parameter, perform a sleep analysis based on the state of the patient, activate the generator to trigger production of the stimulation pulses, determine a variation of the biological parameter subsequent to the production of the stimulation pulses, determine a response of the patient to the stimulation pulses according to the variation of the biological parameter, and determine a sleep stage of the patient based on the response.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: June 4, 2019
    Assignees: SORIN CRM SAS, UNIVERSITE JOSEPH FOURIER—GRENOBLE 1, INSERM—INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITÉ RENNES 1
    Inventors: Laurence Graindorge, Amel Amblard, Christine Henry, Marcel Limousin, Laure Duchemin Laporte, Alfredo Hernandez, Jean-Louis Pépin
  • Patent number: 10299984
    Abstract: A system includes a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a cessation of the respiratory disorder. The processor is further configured to extend the stimulation control signals for a determined duration following the cessation of the respiratory disorder.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: May 28, 2019
    Assignees: SORIN CRM SAS, INSERM-INSTITUT DE LA RECHERCHE MÉDICALE, UNIVERSITÉ JOSEPH FOURIER, UNIVERSITÉ DE RENNES 1
    Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
  • Patent number: 10300280
    Abstract: An active implantable medical device includes a VNS pulse bursts generator for stimulation of the vagus nerve according to several selectable configurations. The device may further include a sensor of the current activity level of the patient. The generator is controlled on the activity signal via a classifier determining the of class the current level of activity among a plurality of classes of activity. A controller selects a configuration of VNS therapy depending on the class of activity thus determined. Limits of the activity classes are dynamically changeable by a calibration module that conducts a historical analysis of the successive current activity levels over a predetermined analysis period. The calibration module can prepare a histogram of the historical analysis, and can define the limits of the activity classes depending on the outcome of the historical analysis and the histogram.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: May 28, 2019
    Assignee: Sorin CRM SAS
    Inventor: Jean-Luc Bonnet
  • Patent number: 10300267
    Abstract: The disclosure relates to a lead including a connector for connection to a generator, a demultiplexing circuit receiving at its input on the first conductors of the electrical control signals from the control bus and whose output is connected to a plurality of second conductors contained in the lead and connected to the lead electrodes. The lead further includes a gate and connection circuit component having a body forming a support for an integrated circuit for demultiplexing and defining a set of connection cavities with the second conductor distributed at the periphery of the body around a general axis of the body, and a plurality of connecting elements embedded in the body material, and emerging at an element region and supporting the circuit at respective cavities. The gate and connection circuit component is advantageously made of ceramic-metal.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: May 28, 2019
    Assignee: Sorin CRM SAS
    Inventors: Nicolas Shan, Philippe D'Hiver
  • Patent number: 10292898
    Abstract: A device includes a processor configured to detect a respiratory disorder episode and generate kinesthetic stimulation control signals in response to the detection of a respiratory disorder episode. The device further includes at least one kinesthetic effector adapted to be applied to a patient's outer skin site and includes a vibrating electromechanical transducer capable of receiving stimulation control signals and outputting a kinesthetic stimulation energy determined by the stimulation control signals. The processor is further configured to determine the effectiveness of stimulation by detecting a cessation of the respiratory disorder episode. The processor is further configured to determine a stimulation energy by selecting an initial energy value and varying the energy value as a function of the effectiveness of previous stimulation.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: May 21, 2019
    Assignees: SORIN CRM SAS, INSERM-INSTITUT DE LA RECHERCHE MÉDICALE, UNIVERSITÉ JOSEPH FOURIER, UNIVERSITÉDE RENNES 1
    Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
  • Patent number: 10292897
    Abstract: A system includes a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a disappearance of the respiratory disorder. The processor is further configured to determine a therapy by selecting a stimulation strategy among several stimulation strategies according to a type of expected or detected disorder.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: May 21, 2019
    Assignees: SORIN CRM SAS, INSERM—INSTITUT DE LA RECHERCHE MÉDICALE, UNIVERSITÉ JOSEPH FOURIER, UNIVERSITÉ DE RENNES 1
    Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
  • Publication number: 20190126048
    Abstract: An active implantable medical device for neurostimulation therapy is disclosed. The device produces stimulation pulse sequences generated continuously in succession during activity periods separated by intermediate inactivity periods during which no stimulation is issued. An input signal, provided by a physiological sensor, representative of cardiac activity and/or of the patient's hemodynamic status is received by circuitry. The circuitry further provides for dynamic control of the neurostimulation therapy, wherein the length of activity periods is modulated based on the current value level of the control parameter compared to a threshold. The duration of the next period of inactivity is calculated by the circuitry at the end of each activity period to maintain a constant duty cycle ratio between periods of activity and periods of inactivity.
    Type: Application
    Filed: December 21, 2018
    Publication date: May 2, 2019
    Applicants: SORIN CRM SAS, UNIVERSITÉ DE RENNES 1, INSERM - INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero
  • Patent number: 10271752
    Abstract: A microlead has a distal active portion formed by a microcable including an electrically conductive core coated with an insulation layer, with a plurality of exposed areas forming the stimulation electrodes. The microcable has a three-dimensional preshape inscribed in a cylindrical envelope volume so as to match the target vessel wall. The microcable includes a plurality of exposed areas regularly distributed over the circumference of the cylindrical envelope volume considered in axial projection, the exposed zones extending only over an angular sector of the microcable considered in cross section, said angular sector facing the outside of the envelope volume of the preshape.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: April 30, 2019
    Assignee: Sorin CRM SAS
    Inventors: Willy Régnier, Philippe d'Hiver
  • Patent number: 10251809
    Abstract: A device for treating sleep apnea in a patient through stimulation. The device includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, and a controller. The controller is configured to determine a sleep state of the patient, adaptively control the generator based on the sleep state where the sleep state includes a plurality of sleep stages, and modulate a stimulation energy of the stimulation pulses produced by the generator based on the sleep stage of the patient.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: April 9, 2019
    Assignees: Sorin CRM SAS, INSERM—INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITÉ DE RENNES 1, UNIVERSITE JOSEPH FOURIER—GRENOBLE 1
    Inventors: Laurence Graindorge, Amel Amblard, Christine Henry, Marcel Limousin, Laure Duchemin Laporte, Alfredo Hernandez, Jean-Louis Pépin
  • Publication number: 20190083802
    Abstract: An implantable cardiac device that detects and protects against strong magnetic fields produced by MRI equipment is disclosed. The device has a magnetic field sensor for detecting the presence of a relatively weak static magnetic field (102, 110, 118, 122) of a level equivalent to that of a permanent magnet in the vicinity of the device. The device is switched from a standard operating mode (100) where the nominal functions of the device are active, to a specific protected MRI mode (114, 116) in the presence of a magnetic static field of a level corresponding to that emitted by MRI equipment. The device further temporarily switches the device from the standard operating mode (100) to an MRI stand-by state (108) when a magnetic field is detected by the magnetic field sensor such that a subsequent detection of a magnetic field switches the device from an MRI stand-by state to the specific protected MRI mode.
    Type: Application
    Filed: November 16, 2018
    Publication date: March 21, 2019
    Applicant: SORIN CRM SAS
    Inventors: Thierry Legay, Dominique Decoene
  • Patent number: 10226622
    Abstract: This accessory comprises a remotely steerable catheter (40) extended by a tip (50) comprising a base (52) to which the catheter (40) connects to and a cylindrical portion (54) defining a volume (56) suitable for housing the capsule (10). A sub-catheter (30) and the capsule are telescopically extendable with respect to the catheter between i) a retracted position and a deployed position wherein the capsule is removed from the connector and is carried by the distal end of the sub-catheter, and the distal end of sub-catheter and the proximal region (18) of the capsule being provided with disconnectable means of attachment (20, 36). The tip presents, between its base (52) and its cylindrical portion (54), a flexible portion (58) providing, between the base and the cylindrical portion, an elastic deformability in bending and compression.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: March 12, 2019
    Assignee: Sorin CRM SAS
    Inventors: Jean-François Ollivier, Willy Régnier
  • Publication number: 20190070408
    Abstract: An autonomous capsule includes a tubular body provided at its distal end with an anchoring screw, and in its proximal region of a capture groove. An explantation accessory includes a reinforced catheter combined with a flexible wire which can slide in the catheter and has a deformable loop which can be clamped by gradual introduction of its ends in the catheter under the effect of a traction exerted on the wire. During tightening, the capture groove receives the wire loop, allowing, after complete tightening, to secure in tension and rotation an assembly formed by the catheter, the capsule, and the wire. The reinforced catheter is then used to transmit a tensile force and an axial torque from its proximal end to its distal end, allowing safe unscrewing of the capsule and its extraction through the patient venous network.
    Type: Application
    Filed: November 8, 2018
    Publication date: March 7, 2019
    Applicant: SORIN CRM SAS
    Inventors: Jean-François Ollivier, Philippe D'hiver, Willy Regnier
  • Publication number: 20190038905
    Abstract: A hybrid system forming an active implantable medical device includes a subcutaneous autonomous capsule and at least one intracorporeal autonomous leadless capsule. The subcutaneous capsule is a hybrid capsule having a seal body of dimensions comparable to those of a leadless capsule, but extended by a detection/stimulation microlead, without any intermediate connector. The leadless capsule includes a seal body, anchoring means in a wall of an organ and a detection/stimulation electrode. The hybrid capsule and the leadless capsules each include transmitter/receiver means for intracorporeal mutual wireless communication so as to constitute a network wherein the hybrid capsule is the master and leadless capsules are the slaves. The hybrid capsule further includes means for centralizing data transmitted by the leadless capsules and for exchanging data with remote external equipment.
    Type: Application
    Filed: October 12, 2018
    Publication date: February 7, 2019
    Applicant: SORIN CRM SAS
    Inventor: Willy Régnier
  • Patent number: 10183161
    Abstract: A microlead, of an overall diameter less than 0.5 mm, includes a plurality of at least eight conductor wires individually insulated and twisted together. Each conductor wire includes an electrically conductive core microcable and an insulation layer surrounding the core microcable and having at least one exposed area to form a detection/stimulation electrode of the microlead. The microlead further includes a central support structure shaped as a surface of revolution, which may be free of conductor wires and of central lumen. The conductor wires are configured in one or more layers of twisted peripheral conductor wires carried by the central support structure and circumferentially distributed thereon.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: January 22, 2019
    Assignee: Sorin CRM SAS
    Inventors: Nicolas Shan, The-hoa Lai
  • Patent number: 10182730
    Abstract: A lead for active implantable medical devices comprising a chip, notably for electrode multiplexing. The lead includes an insulating supporting tube interposed in a flexible elongated tube, with a central bore coaxial with the lumen of the lead. The supporting tube comprises on its surface at least one crossing conductive strip extending in the axial direction. A chip on a flexible substrate is disposed with a bent or curved conformation in a receptacle of the supporting tube isolated from the conductive strip. An electrode, e.g., for cardiac sensing/pacing, carried by the supporting tube is electrically connected to an outer conductive pad of the chip. The conductive strip is connected (i) at each end, face to face to a conductive connection, housed in the sheath, and (ii) in a central region, to an inner conductive pad of the chip.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: January 22, 2019
    Assignee: Sorin CRM SAS
    Inventor: Jean-François Ollivier
  • Publication number: 20190001118
    Abstract: A method of manufacturing a detection/stimulation lead for implantation into a venous, arterial, or lymphatic network is shown and described. The method includes providing a microcable comprising a sheath of insulating material covering an electrically conductive core. The method further includes surrounding a portion of the microcable with an electrically conductive metal ring. The method also includes crimping the ring such that the thickness of the sheath is penetrated by a portion of the metal ring and such that an electrical connection is formed between the metal ring and the electrically conductive core.
    Type: Application
    Filed: September 7, 2018
    Publication date: January 3, 2019
    Applicant: SORIN CRM SAS
    Inventors: Jean-François Ollivier, Nicolas Shan, Philippe D'Hiver
  • Patent number: 10166393
    Abstract: The invention relates to an active implantable medical device. The device includes a VNS pulse generator, an activity sensor for detecting a patient's current activity level, and a processor. The processor is configured to collect the electrical activity of the heart, such as a current intrinsic heart rate of the patient. The processor further calculates values of a reference heart rate based on the patient's current activity level. A first histogram is constructed from the reference heart rate values, and a second histogram is constructed from the intrinsic heart rate values. An index representative of the patient's condition is derived by comparing the first and second histograms.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: January 1, 2019
    Assignees: SORIN CRM SAS, UNIVERSITÉ DE RENNES 1
    Inventors: Jean-Luc Bonnet, Mélanie Mullemeester, Alfredo Hernandez, Guy Carrault
  • Publication number: 20180369588
    Abstract: This disclosure relates to an implantable probe for electrical stimulation of an organ and/or for detection of electrical potentials on this organ. The probe comprises a distal end able to come into contact with the tissues of the organ, this end comprising an insulating substrate, and at least one conductive interface carried by the substrate. The probe further comprises a probe body having at least one bonding conductor connected to a respective conductive interface. The conductive interface comprises at least one deformable conductive wire, at least partially exposed, with a woven, embroidered, braided or knitted configuration for anchoring the deformable wire to the substrate.
    Type: Application
    Filed: December 9, 2016
    Publication date: December 27, 2018
    Applicant: SORIN CRM SAS
    Inventors: Maxime Rault, Patrick Le Gousse