Patents Assigned to Sorin CRM SAS
  • System implantable into the coronary venous network for the stimulation of a cardiac left cavity
    Patent number: 9907951
    Abstract: This system includes a conductor microcable and an insulating microcatheter, including a hollow tube housing the microcable with the possibility of relative axial translation therebetween. The microcatheter is suitable for permanent implantation. The microcatheter, in its distal portion, includes at least one lateral window formed by a through orifice formed on the wall of the hollow tube. The window forms a stimulation site defined on the wall of the target vein facing the window of the microcatheter, and provides for a region of the microcable surface located at the window to form a stimulation electrode. In its distal portion, the microcable is not isolated at least in the region of the window of the microcatheter. The microcatheter is telescopically moveable on the microcable, so as to modify the position of the stimulation site of the target vein.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: March 6, 2018
    Assignee: SORIN CRM SAS
    Inventors: Willy Régnier, Nicolas Shan, Jean-François Ollivier
  • Intracardiac capsule implantable on a thin wall, including the septum wall
    Patent number: 9884185
    Abstract: An intracardiac capsule comprises a cylindrical body having an atraumatic rounded surface and a helical anchoring screw integral with the cylindrical body. The helical anchoring screw is able to penetrate tissue of a wall of the heart and is configured to provide temporary attachment, in rotation and in translation, of the capsule to an implantation site. The helical anchoring screw surrounds at least a portion of the length of the cylindrical body forming a contact region intended to come into contact with the wall of the cavity of the heart. Over the length of the contact region, the external diameter of the cylindrical body is less than the inner diameter of the helical anchoring screw, so as to leave a free gap there between. The helical anchoring screw is secured to the cylindrical body near the proximal end of the contact region, and extends freely to the opposite distal end.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: February 6, 2018
    Assignee: SORIN CRM SAS
    Inventor: Jean-François Ollivier
  • Use of an implantable cardiac pacing, defibrilation and/or resynchronization generator as a VNS generator for vagus nerve stimulation
    Patent number: 9884194
    Abstract: On a channel of an implantable cardiac generator, a cardiac lead is replaced by a vagus nerve stimulation VNS lead. The control circuit controlling the stimulation circuit of this channel of the generator is configured to generate sequences of VNS neurostimulation bursts according to a specific profile, synchronized or not with the heart rate. The control circuit dynamically controls the initial load voltage of the reservoir capacitor so as to adjust to a constant target value the electrical charge delivered to the nerve by each stimulating pulse, from a pulse to the next one and from a burst to the next one. This improves the consistency of the physiological effects of neurostimulation despite significant variations that may occur in impedance at the electrode/vagus nerve interface.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: February 6, 2018
    Assignee: SORIN CRM SAS
    Inventors: Thierry Legay, Hervé Blumstein, Guillaume Chatalic, Christine Henry
  • Pacemaker with detection of atrial activity without collection of atrial electrical activity
    Patent number: 9884193
    Abstract: The invention relates to an active implantable pacemaker. The device analyzes a ventricular electrogram signal (EGM) and is able to recognize, in a search window, an EA4 component of endocardial acceleration (EA) associated with atrial activity. In the presence of atrioventricular conduction, the search window is determined based on the temporal position of the EA1 and/or EA2 components of the EA signal. In the absence of atrioventricular conduction, a delay is counted from a paced ventricular event and applied to mask the EA1 and/or EA2 components in the EA signal, and the window for research of the EA4 component follows the masking delay. In the presence of a confirmed EA4 component, an atrioventricular delay is applied, counted from the EA4 component, and in the opposite case a predetermined escape interval is applied, counted from the last stimulated ventricular event.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: February 6, 2018
    Assignees: SORIN CRM SAS, UNIVERSITÉ DE BRETAGNE OCCIDENTALE, CENTRE HOSPITALIER RÉGIONAL ET UNIVERSITAIRE DE BREST
    Inventors: Amel Amblard, Jérôme Dumont, Fabrizio Renesto, Jacques Mansourati
  • Active implantable medical device with automatic optimization of the configuration of a multi-electrode stimulation lead
    Patent number: 9855428
    Abstract: A device includes a pulse generator coupled to a neurostimulation lead placed around the nerve and a set of electrodes individually connected to the generator by a splitter circuit controlled to preferentially stimulate certain regions of the nerve relative to other regions. The device performing an iterative search of an optimal configuration operating by selection of a plurality of different stimulation configurations, storing of a cardiac physiological parameter measured for each selected stimulation configuration, and designation as optimal stimulation configuration of the one of said selected different stimulation configurations, depending on at least the stored values of the physiological parameter measured for different electrode configurations.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: January 2, 2018
    Assignees: SORIN CRM SAS, INRIA—Institut National de Recherche en Informatique et en Automatique
    Inventors: Christine Henry, Laure Laporte-Duchemin, David Andreu, Christine Azevedo-Coste, David Guiraud, Pawel Maciejasz, Olivier Rossel
  • ACTIVE IMPLANTABLE MEDICAL DEVICE FOR THE DIAGNOSIS OF CARDIAC DECOMPENSATION
    Publication number: 20170368353
    Abstract: The disclosure relates to a device including a plurality of electrodes for stimulation of both ventricles with application of an atrioventricular delay and of an interventricular delay, a processor configured to multidimensionally measure an interventricular conduction delay, and monitor the evolution of a patient's condition. For the multidimensional measurement of the interventricular conduction delay, the device produces stimulation of one of the ventricles and collects, in the other ventricle, two endocardial electrogram signals on separate respective channels, giving two respective temporal components. Both temporal components are combined in one single parametric 2D characteristic representative of the cardiac cycle, and a comparison is made with reference descriptors for deriving an index representative of the evolution of the patient's condition.
    Type: Application
    Filed: September 11, 2017
    Publication date: December 28, 2017
    Applicant: SORIN CRM SAS
    Inventors: Marie-Anne Euzen, Paola Milpied
  • ACTIVE IMPLANTABLE MEDICAL DEVICE FOR DETECTING A REMODELING OR REVERSE REMODELING PHENOMENON OF THE PATIENT
    Publication number: 20170368349
    Abstract: According to some embodiments, a device operates by comparative morphological analysis of depolarization signals collected in spontaneous rhythm on separate respective channels, with two temporal components combined into a single 2D parametric VGM vectogram characteristic. Similarity quantification methods evaluate a variation over time of a descriptor parameter of a current VGM compared to a stored previous reference VGM. This variation is compared with predetermined thresholds to diagnose an occurrence of remodeling or reverse remodeling in a patient, and/or to detect a lead failure or an occurrence of ischemia. The descriptor parameter is a function of a velocity vector of the VGM, a comparison relating to a correlation coefficient between respective magnitudes of a current VGM velocity vector and of a reference VGM velocity vector, and an average angle between these respective velocity vectors.
    Type: Application
    Filed: September 11, 2017
    Publication date: December 28, 2017
    Applicant: SORIN CRM SAS
    Inventors: Paola Milpied, Marie-Anne Euzen
  • Coronary venous pacing lead and anchoring screw system
    Patent number: 9849280
    Abstract: A system implantable in the coronary venous system, including a pacing lead with an anchoring screw is disclosed. The system includes a stimulation lead (10) for stimulating a left heart cavity of a patient, and a removable catheter (26) for implanting the lead. The lead (10) has at least one stimulation electrode having an anchoring screw (14) that penetrates into the epicardial tissue of the patient. The catheter tube (26) is a pre-shaped tube with two curvatures in the absence of stress. The two curvatures are inscribed in two separate surfaces (38, 40) for self-orientating the distal end of the catheter tube into the target vein and maintaining the axis of the anchoring screw towards the epicardial wall during the screwing of the lead head.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: December 26, 2017
    Assignee: SORIN CRM SAS
    Inventor: Jean Francois Ollivier
  • DETECTION/STIMULATION MICROLEAD IMPLANTABLE IN A VESSEL OF THE VENOUS, ARTERIAL OR LYMPHATIC NETWORK
    Publication number: 20170340224
    Abstract: A microlead has a distal active portion formed by a microcable including an electrically conductive core coated with an insulation layer, with a plurality of exposed areas forming the stimulation electrodes. The microcable has a three-dimensional preshape inscribed in a cylindrical envelope volume so as to match the target vessel wall. The microcable includes a plurality of exposed areas regularly distributed over the circumference of the cylindrical envelope volume considered in axial projection, the exposed zones extending only over an angular sector of the microcable considered in cross section, said angular sector facing the outside of the envelope volume of the preshape.
    Type: Application
    Filed: August 11, 2017
    Publication date: November 30, 2017
    Applicant: SORIN CRM SAS
    Inventors: Willy Régnier, Philippe d'Hiver
  • Active implantable medical device with cardiac lead and peripheral lead discrimination
    Patent number: 9808638
    Abstract: The device includes a cardiac therapy circuit with a first terminal, and a peripheral therapy circuit with a second terminal. These terminals can either receive a cardiac detection/stimulation lead or a peripheral detection/stimulation lead of an organ. The device is configured to recognize the leads and automatically configure the connection terminals according to the type of lead received by the terminal. This includes discrimination methods for identifying the terminal on which a cardiac signal is detected, and selectively activating the cardiac therapy circuit and the peripheral therapy circuit based on the detection of the cardiac signal on a lead.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: November 7, 2017
    Assignee: SORIN CRM SAS
    Inventors: Hervé Blumstein, Hervé Mével
  • Active implantable medical device with cardiac lead and peripheral lead discrimination
    Patent number: 9795798
    Abstract: The device includes a cardiac therapy circuit with a first terminal, and a peripheral therapy circuit with a second terminal. These terminals can either receive a cardiac detection/stimulation lead and a peripheral detection/stimulation lead of an anatomical structure. The device is configured to recognize the leads and automatically configure the connection terminals. This includes discrimination methods for identifying the terminal on which a cardiac signal is detected, and switching methods for coupling the cardiac therapy circuit to the terminal and the peripheral therapy circuit to the other terminal.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: October 24, 2017
    Assignee: SORIN CRM SAS
    Inventors: Hervé Blumstein, Hervé Mével
  • System with kinesthetic stimulation medical device for the non-invasive assessment of the sympathovagal balance of a patient
    Patent number: 9782117
    Abstract: A system for assessing a sympathovagal balance of a patient includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and outputs a stimulation energy, a sensor configured to measure a physiological signal, and a processor. The processor is configured to control the generator during a plurality of sequences to produce the stimulation pulses over a test period, determine a biological parameter of a current activity of the patient derived from the physiological signal, determine a variation of the biological parameter resulting from the stimulation pulses, and determine a sympathovagal balance index according to the variation in the biological parameter.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: October 10, 2017
    Assignees: SORIN CRM SAS, UNIVERSITÉ DE RENNES 1
    Inventors: Jean-Luc Bonnet, Alfredo Hernandez
  • Retractable screw intracardiac lead for cardiac stimulation and/or defibrillation
    Patent number: 9770585
    Abstract: A retractable screw-type stimulation or defibrillation intracardiac lead is disclosed. According to one embodiment, the lead comprises a flexible hollow sheath (12) having at its distal end a lead head (10) and a connector (66) at its proximal end. The connector comprises a pin (62) connected to a lead head electrode (18). The lead head comprises a tubular body (28), at least one electrode (18, 20) for stimulation or defibrillation, a moving element translationally and rotationally moving within the tubular body in a helical motion, and an anchoring screw (24) axially moving with respect to the tubular body, and a deployment mechanism (22) to deploy the anchoring screw out of the tubular body (28).
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: September 26, 2017
    Assignee: SORIN CRM SAS
    Inventor: Jean-François Ollivier
  • Active implantable medical device for the treatment of heart failure with vagus nerve stimulation in synchrony with cardiac activity
    Patent number: 9770594
    Abstract: A medical device includes a VNS pulse burst generator for stimulation of the vagus nerve, and a controller for analyzing the cardiac rhythm. It further includes a sequencer that uses an estimator to calculate during a given cycle an estimate of the temporal position of the R wave of the next cycle. The controller is configured to define the moment of application of the VNS pulse burst as an instant corresponding to the estimate minus a predetermined advance delay. VNS therapy is thus delivered in a non-vulnerable period, near the end of the period of natural ventricular escape.
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: September 26, 2017
    Assignee: SORIN CRM SAS
    Inventors: Jean-Luc Bonnet, Christine Henry
  • Neural network system for the evaluation and the adaptation of antitachycardia therapy by an implantable defibrillator
    Patent number: 9764151
    Abstract: The system includes an active medical device with means for delivering defibrillation shocks; means for continuous collection of the patient current cardiac activity parameters; and evaluator means with neuronal analysis comprising a neural network with at least two layers. This neural network comprises upstream three neural sub-networks receiving the respective parameters divided into separate sub-groups corresponding to classes of arrhythmogenic factors; and downstream an output neuron coupled to the three sub-networks and capable of outputting an index of risk of ventricular arrhythmia. The risk index is compared with a given threshold, to enable or disable at least one function of the device in case of crossing of the threshold.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: September 19, 2017
    Assignee: SORIN CRM SAS
    Inventors: Charles-Henri Cappelaere, Amel Amblard, Sylvain Christophle-Boulard, Gérard Dreyfus, Rémi Dubois, Pierre Roussel
  • Active implantable medical device for detecting a remodeling or reverse remodeling phenomenon of the patient
    Patent number: 9757566
    Abstract: According to some embodiments, a device operates by comparative morphological analysis of depolarization signals collected in spontaneous rhythm on separate respective channels, with two temporal components combined into a single 2D parametric VGM vectogram characteristic. Similarity quantification methods evaluate a variation over time of a descriptor parameter of a current VGM compared to a stored previous reference VGM. This variation is compared with predetermined thresholds to diagnose an occurrence of remodeling or reverse remodeling in a patient, and/or to detect a lead failure or an occurrence of ischemia. The descriptor parameter is a function of a velocity vector of the VGM, a comparison relating to a correlation coefficient between respective magnitudes of a current VGM velocity vector and of a reference VGM velocity vector, and an average angle between these respective velocity vectors.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: September 12, 2017
    Assignee: SORIN CRM SAS
    Inventors: Paola Milpied, Marie-Anne Euzen
  • Active implantable medical device for the diagnosis of cardiac decompensation
    Patent number: 9757568
    Abstract: The disclosure relates to a device including a plurality of electrodes for stimulation of both ventricles with application of an atrioventricular delay and of an interventricular delay, a processor configured to multidimensionally measure an interventricular conduction delay, and monitor the evolution of a patient's condition. For the multidimensional measurement of the interventricular conduction delay, the device produces stimulation of one of the ventricles and collects, in the other ventricle, two endocardial electrogram signals on separate respective channels, giving two respective temporal components. Both temporal components are combined in one single parametric 2D characteristic representative of the cardiac cycle, and a comparison is made with reference descriptors for deriving an index representative of the evolution of the patient's condition.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: September 12, 2017
    Assignee: SORIN CRM SAS
    Inventors: Marie-Anne Euzen, Paola Milpied
  • RF telemetry receiver circuit for active medical implants
    Patent number: 9748986
    Abstract: An RF telemetry receiver circuit for active implantable medical devices. The baseband binary signal (Db) is doubly modulated by a low frequency carrier (Fm) and by a high frequency carrier (Fc). The receiver circuit is a semi-passive non heterodyne circuit, devoid of a local oscillator and mixer. It comprises an antenna (104), a passive bandpass filter (108) centered on the high-frequency carrier (Fc), a passive envelope detector (120-126) and a digital demodulator (116). The envelope detector comprises a first diode circuit (120) of non-coherent detection, an active bandpass filter (122) centered on a frequency (2.Fm) twice the low frequency carrier and having a bandwidth (2.Db) twice the baseband bandwidth, and a second diode circuit (124) of non-coherent detection, outputting a baseband signal applied to the digital demodulation stage (116).
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: August 29, 2017
    Assignee: SORIN CRM SAS
    Inventor: Alaa Makdissi
  • Atraumatic detection/stimulation microlead
    Patent number: 9743852
    Abstract: An atraumatic detection/stimulation lead is disclosed. The lead includes at least one microcable having a core cable comprising a plurality of elementary metal strands. One of the microcables has provided at its distal end an atraumatic protection device. The atraumatic protection device includes a protective coating on the distal ends of the elementary strands of the microcable, and the protective coating is covered by a protective cap of deformable material. The protective cap may be a conical distal end adapted to deform and axially flatten out. The microcable may have an overall diameter less than or equal to 1.5 French (0.50 mm).
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: August 29, 2017
    Assignee: SORIN CRM SAS
    Inventors: Willy Régnier, Nicolas Shan
  • Detection/stimulation microlead implantable in a vessel of the venous, arterial or lymphatic network
    Patent number: 9730595
    Abstract: A microlead has a distal active portion formed by a microcable including an electrically conductive core coated with an insulation layer, with a plurality of exposed areas forming the stimulation electrodes. The microcable has a three-dimensional preshape inscribed in a cylindrical envelope volume so as to match the target vessel wall. The microcable includes a plurality of exposed areas regularly distributed over the circumference of the cylindrical envelope volume considered in axial projection, the exposed zones extending only over an angular sector of the microcable considered in cross section, said angular sector facing the outside of the envelope volume of the preshape.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: August 15, 2017
    Assignee: SORIN CRM SAS
    Inventors: Willy Régnier, Philippe d'Hiver