Patents Assigned to Sosei Co., Ltd.
  • GM-95-containing antitumor effect potentiator, combined antitumor preparation and antitumor agent
    Patent number: 7470714
    Abstract: An antitumor effect enhancer for enhancing the antitumor effects of an antitumor substance, which comprises a compound represented by the following formula (1): wherein each R independently represents a hydrogen atom, a lower alkyl group, an aryl group, an allyl group, an aralkyl group, a halogen atom, a hydroxyl group, an amino group, R?O—, R?(C?O)—, R?(C?O)O—, or R?O(C?O)—, wherein R? is an alkyl group containing 1 to 5 carbon atoms, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 4, 2004
    Date of Patent: December 30, 2008
    Assignee: Sosei Co., Ltd.
    Inventors: Kazuo Shinya, Tetsuzo Tauchi, Toshiro Morohoshi, Takashi Ono
  • microorganism and a process for producing the substance GM-95
    Patent number: 7192763
    Abstract: A compound which has the following formula (1), a process for its production, a pharmaceutical composition comprising the compound as an active ingredient, a method of treating tumor which comprises administering the compound, use of the compound as a medicine, and a microorganism capable of producing the compound. The compound of the present invention is a novel compound which has antitumor action and is useful as a medicine.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: March 20, 2007
    Assignee: Sosei Co., Ltd.
    Inventors: Haruo Seto, Kazuo Shin-Ya, Konstanty Wierzba
  • Process for preparing substance GM-95
    Patent number: 6818764
    Abstract: A method of manufacturing substance GM-95 having general formula [I], comprising (a) deprotecting a macrocyclic compound having general formula [II] (wherein, R1's are the same or different and each represents a lower alkyl group, and R2 represents a thiol protecting group) by removing acetal protecting groups (the R1's) thereof, and forming an oxazole ring through an intramolecular cyclization reaction between produced formyl group and an amide group, and (b) deprotecting a resulting macrocyclic compound having general formula [III] (wherein, R2 is as mentioned above) by removing the thiol protecting group (R2) thereof, and forming a thiazoline ring through an intramolecular cyclization reaction between a thiol group thus produced and an amide group.
    Type: Grant
    Filed: June 3, 2003
    Date of Patent: November 16, 2004
    Assignees: Taiho Pharmaceutical Co., Ltd., Sosei Co., Ltd.
    Inventors: Shozo Yamada, Kazuhiko Shigeno, Kazuhiro Kitagawa, Shigeo Okajima, Tetsuji Asao
  • Substance GM-95, process for producing the same and utilization thereof
    Patent number: 6613759
    Abstract: A compound which has the following formula (1), a process for its production, a pharmaceutical composition comprising the compound as an active ingredient, a method of treating tumor which comprises administering the compound, use of the compound as a medicine, and a microorganism capable of producing the compound. The compound of the present invention is a novel compound which has antitumor action and is useful as a medicine.
    Type: Grant
    Filed: April 9, 2001
    Date of Patent: September 2, 2003
    Assignees: Taiho Pharmaceutical Co., Ltd., Sosei Co., Ltd.
    Inventors: Haruo Seto, Kazuo Shin-Ya, Konstanty Wierzba