Patents Assigned to SOTIO a.s.
  • Coumarin derivatives, processes for their preparation and uses thereof for the treatment of cancer
    Patent number: 11111238
    Abstract: The invention provides novel coumarin derivatives as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: September 7, 2021
    Assignees: Lead Discovery Center GmbH, Max Planck Gesellschaft zur Förderung der Wissenschften e.V., SOTIO a.s.
    Inventors: Raffaella Di Lucrezia, Tim Bergbrede, Peter Nussbaumer, Uwe Koch, Bert Klebl, Axel Choidas, Anke Unger, Nils-Göran Larsson, Maria Falkenberg-Gustafsson, Claes M. Gustafsson
  • Means and methods for active cellular immunotherapy of cancer by using tumor cells killed by high hydrostatic pressure and dendritic cells
    Patent number: 10918704
    Abstract: Disclosed are pharmaceutical compositions for inducing an immune response against tumor cells comprising tumor cells which are made apoptotic by treatment with high hydrostatic pressure and dendritic cells, and methods for producing such compositions.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: February 16, 2021
    Assignee: SOTIO a.s.
    Inventors: Ji{hacek over (r)}ina Bartů{hacek over (n)}ková, Radek {hacek over (S)}pí{hacek over (s)}ek
  • Means and methods for active cellular immunotherapy of cancer by using tumor cells killed by high hydrostatic pressure and dendritic cells
    Patent number: 10905751
    Abstract: Disclosed are pharmaceutical compositions for inducing an immune response against tumor cells comprising tumor cells which are made apoptotic by treatment with high hydrostatic pressure and dendritic cells, and methods for producing such compositions.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: February 2, 2021
    Assignee: SOTIO a.s.
    Inventors: Ji{hacek over (r)}ina Bartů{hacek over (n)}ková, Radek {hacek over (S)}pí{hacek over (s)}ek
  • Cryopreservation of apoptotic cancer cells for use in immunotherapy against cancer
    Patent number: 10561717
    Abstract: Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells undergoing immunogenic cell death, and using such cells to activate dendritic cells for use in immunotherapy. In a specific embodiment, the method comprises cryopreserving cancer cells undergoing cell death, which can be used to prepare a pharmaceutical composition for immunotherapy against cancer.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: February 18, 2020
    Assignee: SOTIO a.s.
    Inventors: Jitka Fucikova, Lenka Koci, Katerina Pokorna, Iva Truxova, Irena Moserova, Daniela Rozkova, Radek Spisek
  • Cryopreservation of apoptotic cancer cells for use in immunotherapy against cancer
    Patent number: 10155033
    Abstract: Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells undergoing immunogenic cell death, and using such cells to activate dendritic cells for use in immunotherapy. In a specific embodiment, the method comprises cryopreserving cancer cells undergoing cell death, which can be used to prepare a pharmaceutical composition for immunotherapy against cancer.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: December 18, 2018
    Assignee: SOTIO A.S.
    Inventors: Jitka Fucikova, Lenka Koci, Katerina Pokorna, Iva Truxova, Irena Moserova, Daniela Rozkova, Radek Spisek
  • Tolerogenic dendritic cells, methods of producing the same, and uses thereof
    Patent number: 9987307
    Abstract: Described herein are methods for the preparation of stable semi-mature tolerogenic dendritic cells and compositions comprising such stable semi-mature tolerogenic dendritic cells. The stable semi-mature tolerogenic dendritic cells described herein and compositions thereof can be used for the establishment of immune tolerance when treating an autoimmune disease, graft rejection and/or graft-versus-host disease.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: June 5, 2018
    Assignee: SOTIO A.S.
    Inventors: Lenka Palová Jelínková, Klára Dáñová, Radek S̆pí{hacek over (s)}ek
  • Cryopreservation of apoptotic cancer cells for use in immunotherapy against cancer
    Patent number: 9895430
    Abstract: Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells undergoing immunogenic cell death, and using such cells to activate dendritic cells for use in immunotherapy. In a specific embodiment, the method comprises cryopreserving cancer cells undergoing cell death, which can be used to prepare a pharmaceutical composition for immunotherapy against cancer.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: February 20, 2018
    Assignee: SOTIO A.S.
    Inventors: Jitka Fucikova, Lenka Koci, Katerina Pokorna, Iva Truxova, Irena Moserova, Daniela Rozkova, Radek Spisek
  • Cryopreservation of apoptotic cancer cells for use in immunotherapy against cancer
    Patent number: 9562219
    Abstract: Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells undergoing immunogenic cell death, and using such cells to activate dendritic cells for use in immunotherapy. In a specific embodiment, the method comprises cryopreserving cancer cells undergoing cell death, which can be used to prepare a pharmaceutical composition for immunotherapy against cancer.
    Type: Grant
    Filed: December 27, 2013
    Date of Patent: February 7, 2017
    Assignee: SOTIO A.S.
    Inventors: Jitka Fucikova, Lenka Koci, Katerina Pokorna, Iva Truxova, Irena Moserova, Daniela Rozkova, Radek Spisek
  • IN VITRO METHOD FOR THE DIAGNOSIS AND SURVEILLANCE OF CANCER
    Publication number: 20150337384
    Abstract: The present invention relates to an in vitro method for the diagnosis and/or the monitoring and/or predicting the progress of a cancer disease, characterized in that in at least one sample the ratio of Tregs-cells to at least one other group of T cells comprising the group of Th17 cells, Th1 cells and/or Th2 cells is determined.
    Type: Application
    Filed: June 27, 2013
    Publication date: November 26, 2015
    Applicant: SOTIO a.s.
    Inventors: Jirina BARTUNKOVÁ, Radek SPÍSEK
  • CRYOPRESERVATION OF APOPTOTIC CANCER CELLS FOR USE IN IMMUNOTHERAPY AGAINST CANCER
    Publication number: 20150184130
    Abstract: Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells undergoing immunogenic cell death, and using such cells to activate dendritic cells for use in immunotherapy. In a specific embodiment, the method comprises cryopreserving cancer cells undergoing cell death, which can be used to prepare a pharmaceutical composition for immunotherapy against cancer.
    Type: Application
    Filed: December 27, 2013
    Publication date: July 2, 2015
    Applicant: SOTIO a.s.
    Inventors: Jitka Fucikova, Lenka Koci, Katerina Pokorna, Iva Truxova, Irena Moserova, Daniela Rozkova, Radek Spisek
  • MEANS AND METHODS FOR ACTIVE CELLULAR IMMUNOTHERAPY OF CANCER BY USING TUMOR CELLS KILLED BY HIGH HYDROSTATIC PRESSURE AND DENDRITIC CELLS
    Publication number: 20140086957
    Abstract: Disclosed are pharmaceutical compositions for inducing an immune response against tumor cells comprising tumor cells which are made apoptotic by treatment with high hydrostatic pressure and dendritic cells, and methods for producing such compositions.
    Type: Application
    Filed: July 4, 2012
    Publication date: March 27, 2014
    Applicant: SOTIO a.s.
    Inventors: Jirina Bartunková, Radek Spisek
  • Means And Methods For Active Cellular Immunotherapy Of Cancer By Using Tumor Cells Killed By High Hydrostatic Pressure and Dendritic Cells
    Publication number: 20130011438
    Abstract: Disclosed are pharmaceutical compositions for inducing an immune response against tumor cells comprising tumor cells which are made apoptotic by treatment with high hydrostatic pressure and dendritic cells, and methods for producing such compositions.
    Type: Application
    Filed: July 4, 2012
    Publication date: January 10, 2013
    Applicant: SOTIO a.s.
    Inventors: Jirina BARTUNKOVÁ, Radek SPÍSEK