Patents Assigned to Sour Pliva
  • Metal complexes of N-acetyl-glucosaminyl-N-acetyl-muramoyl-L-alanyl-D-isoglutaminyl-(L)-mes o-diamino-pimelyl-(D-amide)-(L)-D-alanyl-D-alanine and their use in pharmaceuticals
    Patent number: 5064812
    Abstract: A complex of N-acetyl-glucosaminyl-N-acetyl-muramoyl-L-alanyl-D-isoglotaminyl- (L)-meso-diamino-pimelyl-(D-amide)-D-alanyl-D-alanine with bivalent metals chosen from the group comprising Cu.sup.2+, Zn.sup.2+, Co.sub.hu 2+ ; Ni.sup.2+ and Cd.sup.2+ in the molar ratio of the organic ligand: Cu.sup.2+ =2:1 and the organic ligand: Zn.sup.2+ or Co.sup.2+ or Ni.sup.2+ or Cd.sup.2+ =1:1, compositions containing it and their use in the treatment of immunological insufficiencies and disturbances in humans and animals.
    Type: Grant
    Filed: December 4, 1989
    Date of Patent: November 12, 1991
    Assignee: Sour Pliva
    Inventors: Bozidar Suskovic, Zlatko Vajtner, Radmila Naumski
  • Derivatives of tylosin and 10,11,12,13-tetrahydro tylosin and their use in pharmaceuticals
    Patent number: 5023240
    Abstract: Derivatives of tylosin and 10,11,12,13-tetrahydro tylosin of the general formula ##STR1## wherein R stands for CHO, CH.sub.2 OH, CH.dbd.NOH or CH(OCH.sub.3).sub.2,R.sup.1 stands for H,R.sup.2 stands for OH orR.sup.1 +R.sup.2 stand for .dbd.O or .dbd.NOH,R.sup.3 stands for a mycarosyl group or a hydrogen atom, andstands for a single or a double bond;methods for the manufacture thereof; their use as antimicrobial agents and processes for the preparation of the latter.
    Type: Grant
    Filed: April 13, 1988
    Date of Patent: June 11, 1991
    Assignee: Sour Pliva
    Inventors: Amalija Narandja, Bozidar Suskovic, Slobodan Djokic, Nevenka Lopotar
  • Metal complexes of N-methyl-11-aza-10-deoxo-10-dihydro-erythromycin A or 11-aza-10-deoxo-10-dihydro-erythromycin A, method for the manufacture thereof and their use in the manufacture of pharmaceuticals
    Patent number: 4963528
    Abstract: New 2:1 complexes of N-methyl-11-aza-10-deoxo-10-dihydroerythromycin A or 11-aza-10-deoxo-10-dihydroerythromycin A with bivalent metals chosen form the group comprising Cu.sup.+2, Zn.sup.+2, Co.sup.+2, Ni.sup.+2 and Ca.sup.+2, a process for their manufacture and their use in the manufacture of antibiotically active pharmaceuticals.New 2:1 complexes of N-methyl-11-aza-10-deoxo-10-dihydroerythromycin A or 11-aza-10-deoxo-10-dihydroerythromycin A with bivalent metals chosen from the group comprising Cu.sup.+2, Zn.sup.+2, Co.sup.+2, Ni.sup.+2 and Ca.sup.+2 are made by reacting N-methyl-11-aza-10-deoxo-10-dihydroerythromycin A or 11-aza-10-deoxo-10-dihydroerythromycin A in its free base form or in its water-soluble salt form with salts of said bivalent metals. The compounds possess antibiotic activity.
    Type: Grant
    Filed: September 9, 1987
    Date of Patent: October 16, 1990
    Assignee: Sour Pliva
    Inventors: Zlatko Vajtner, Nevenka Lopotar, Slobodan Djokic
  • 10-dihydro-10-deoxo-11-azaerythronolide a compounds, methods and intermediates for the manufacture thereof and their use in pharmaceuticals and in the manufacture thereof
    Patent number: 4886792
    Abstract: 10-dihydro-10-deoxo-11-azaerythronolide A compounds and pharmaceutically acceptable acid addition salts of said compounds; methods and intermediates for the manufacture thereof; their use as antiinflammatory agents and processes for their preparation.
    Type: Grant
    Filed: April 12, 1988
    Date of Patent: December 12, 1989
    Assignee: Sour Pliva
    Inventors: Slobodan Djokic, Nevenka Lopotar, Gabrijela Kobrehel, Hrvoje Krnjevic, Olga Carevic
  • 11-Methyl-11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl-7,1 3,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one and derivatives thereof
    Patent number: 4517359
    Abstract: 11-Methyl-11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl-7,13,14-trihydroxy -3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one and derivatives thereof, such as the 13,14-carbonate and C.sub.1 -C.sub.3 -alkanoyl derivatives thereof. The compounds exhibit antibacterial activity.
    Type: Grant
    Filed: September 22, 1981
    Date of Patent: May 14, 1985
    Assignee: Sour Pliva farmaceutska, kemijska prehrambena i kozmeticka industrija, n.sol.o.
    Inventors: Gabrijela Kobrehel, Slobodan Djokic