Patents Assigned to Southern Research Institute
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Patent number: 11753374Abstract: The present disclosure is concerned with biaryl aminomaleimide compounds for the treatment of disorders associated with heme oxygenase-1 (HO-1) signaling dysfunction such as, for example, kidney diseases (e.g., chronic kidney disease, acute kidney injury). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: November 17, 2021Date of Patent: September 12, 2023Assignees: Southern Reserach Institute, The UAB Research Foundation, The United States Government as represented by the Department of Veterans AffairsInventors: Mark J. Suto, Bini Mathew, Anupam Agarwal, Amie M. Traylor
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Patent number: 11752153Abstract: In one aspect, compounds and compositions that inhibit TXNIP expression and/or that lower hepatic glucose production and methods of identifying, making, and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with elevated TXNIP and/or elevated glucagon levels such as, for example, diabetes and associated disorders. Further provided are methods for treating hyperlipidemia or fatty liver disease, optionally associated with elevated TXNIP and/or elevated glucagon levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: November 3, 2022Date of Patent: September 12, 2023Assignees: SOUTHERN RESEARCH INSTITUTE, THE UAB RESEARCH FOUNDATIONInventors: Corinne E. Augelli-Szafran, Omar Moukha-Chafiq, Mark J. Suto, Anath Shalev, Lance Thielen, Junqin Chen, Gu Jing
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Patent number: 11718593Abstract: The present disclosure is concerned with 2,5-amino-thiazole compounds that are capable of activating NF-?B signaling. The present disclosure is also concerned with methods of using these compounds for the treatment of neurological disorders such as, for example, amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, spinal muscular atrophy, traumatic brain injury, vascular dementia, Huntington's disease, mental retardation, and attention deficit and hyperactivity disorder (ADHD), and neuromuscular disorders such as, for example, Duchenne muscular dystrophy (DMD). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: May 16, 2019Date of Patent: August 8, 2023Assignee: Southern Research InstituteInventors: Mark J. Suto, Bini Mathew, Rita Cowell, Corinne E. Augelli-Szafran
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Publication number: 20230172932Abstract: In one aspect, compounds and compositions that inhibit TXNIP expression and/or that lower hepatic glucose production and methods of identifying, making, and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with elevated TXNIP and/or elevated glucagon levels such as, for example, diabetes and associated disorders. Further provided are methods for treating hyperlipidemia or fatty liver disease, optionally associated with elevated TXNIP and/or elevated glucagon levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: November 3, 2022Publication date: June 8, 2023Applicants: SOUTHERN RESEARCH INSTITUTE, THE UAB RESEARCH FOUNDATIONInventors: Corinne E. Augelli-Szafran, Omar Moukha-Chafiq, Mark J. Suto, Anath Shalev, Lance Thielen, Junqin Chen, Gu Jing
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Publication number: 20230159542Abstract: This disclosure provides compounds that inhibit RNA-binding proteins, such as Human antigen R protein (HuR). The compounds described herein have a high affinity for HuR multimers and inhibit the pathological processes that promote cancer and inflammation. The compounds are highly water-soluble and have good biodistribution for both systemic and central nervous system disease processes. The compounds provide a unique therapeutic option for disease processes related to neoplastic progression or acute or chronic inflammation.Type: ApplicationFiled: April 21, 2021Publication date: May 25, 2023Applicants: THE UAB RESEARCH FOUNDATION, SOUTHERN RESEARCH INSTITUTE, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Louis B. Nabors, Natalia Filippova, Xiuhua Yang, Subramaniam Ananthan, Vibha Pathak, Peter King
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Patent number: 11623918Abstract: The present disclosure is concerned with thioquinolinone compounds for the treatment of disorders associated with heme oxygenase-1 (HO-1) signaling dysfunction such as, for example, kidney diseases (e.g., chronic kidney disease, acute kidney injury). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: November 17, 2021Date of Patent: April 11, 2023Assignees: Southern Research Institute, UAB Research Foundation, The United States Government as Represented by the Department of Veterans AffairsInventors: Mark J. Suto, Bini Mathew, Anupam Agarwal, Amie M. Traylor
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Patent number: 11578073Abstract: The present disclosure is concerned with xanthine analogs, methods of making xanthine analogs, and methods of treating West Nile virus using these analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: June 18, 2020Date of Patent: February 14, 2023Assignees: Southern Research Institute, Oregon Health and Science UniversityInventors: Ashish Kumar Pathak, Theresa Ha Nguyen, Corinne E. Augelli-Szafran, Alec Jay Hirsch, Jessica Lee Smith
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Patent number: 11566019Abstract: The present disclosure is concerned with 2-pyrimidone compounds that are capable of inhibiting a viral infection and methods of treating alphavirus viral infections such as, for example, chikungunya, Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), and Venezuelan equine encephalitis using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: April 2, 2021Date of Patent: January 31, 2023Assignees: Southern Research Institute, Oregon Health and Science UniversityInventors: Ashish Kumar Pathak, Corinne E. Augelli-Szafran, Atefeh Garzan, Daniel Streblow, Nicole Haese
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Patent number: 11524010Abstract: In one aspect, compounds and compositions that inhibit TXNIP expression and/or that lower hepatic glucose production and methods of identifying, making, and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with elevated TXNIP and/or elevated glucagon levels such as, for example, diabetes and associated disorders. Further provided are methods for treating hyperlipidemia or fatty liver disease, optionally associated with elevated TXNIP and/or elevated glucagon levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: July 13, 2021Date of Patent: December 13, 2022Assignees: SOUTHERN RESEARCH INSTITUTE, THE UAB RESEARCH FOUNDATIONInventors: Corinne E. Augelli-Szafran, Omar Moukha-Chafiq, Mark J. Suto, Anath Shalev, Lance Thielen, Junqin Chen, Gu Jing
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Patent number: 11505531Abstract: The present disclosure is concerned with piperazine-2,5-diones that are capable of inhibiting TGF-? and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: August 5, 2019Date of Patent: November 22, 2022Assignees: UAB RESEARCH FOUNDATION, SOUTHERN RESEARCH INSTITUTEInventors: Mark J. Suto, Vandana V. Gupta, Wei Zhang, Joanne Murphy-Ullrich
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Patent number: 11478743Abstract: A thermochemical energy storage system and method of storing thermal energy are described. The energy storing system described herein comprises a reactor comprising: a) a reactor with a CO2 sorbent including MgO; and b) a supercritical CO2 source with supercritical CO2 and H2O, wherein the supercritical CO2 source is in fluid communication with the reactor and the CO2 sorbent including MgO to allow flow of the supercritical CO2 and H2O between the supercritical CO2 source and the reactor, thereby allowing contact of CO2 with the CO2 sorbent comprising MgO.Type: GrantFiled: September 18, 2019Date of Patent: October 25, 2022Assignee: Southern Research InstituteInventor: Andrew Jerome Muto
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Patent number: 11472781Abstract: The present disclosure is concerned with 2-aminoaryl-5-aryloxazole compounds that are capable of activating NF-?B signaling. The present disclosure is also concerned with methods of using these compounds for the treatment of neurological disorders such as, for example, amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, spinal muscular atrophy, traumatic brain injury, vascular dementia, Huntington's disease, mental retardation, and attention deficit and hyperactivity disorder (ADHD), and neuromuscular disorders such as, for example, Duchenne muscular dystrophy (DMD). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: February 20, 2019Date of Patent: October 18, 2022Assignee: SOUTHERN RESEARCH INSTITUTEInventors: Mark J. Suto, Bini Mathew, Rita Cowell, Corinne E. Augelli-Szafran
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Patent number: 11447472Abstract: The present disclosure provides crystalline polymorphs of 5-aza-4?-thio-2?-deoxycytidine. The crystalline polymorphs may be formulated in a pharmaceutical composition, optionally in combination with an additional chemotherapeutic agent. The crystalline polymorphs are useful to treat various diseases including blood cancers, such as myelodysplastic syndrome and leukemia. A process for preparing the crystalline polymorphs of 5-aza-4?-thio-2?-deoxycytidine is also disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: July 23, 2021Date of Patent: September 20, 2022Assignees: PINOTBIO, INC., SOUTHERN RESEARCH INSTITUTEInventors: Mark J. Suto, Doo Young Jung, Jin Soo Lee, Hyunyong Cho
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Patent number: 11381224Abstract: Technologies are provided for generation of programmable pulse signals using inverse chaotic maps, without reliance on a clocking signal. Some embodiments of the technologies include an apparatus that can receive a sequence of bits having a defined number of bits, where the sequence of bits represent a desired continuous pulse signal having a programmable width in time-domain. The apparatus can also can receive a precursor continuous pulse signal having an arbitrary width in time-domain that fits within the dynamic range of the apparatus. The apparatus can generate the desired continuous pulse signal by transforming the precursor continuous pulse signal using the sequence of bits and an inverse chaotic map.Type: GrantFiled: June 10, 2019Date of Patent: July 5, 2022Assignee: SOUTHERN RESEARCH INSTITUTEInventor: Seth D. Cohen
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Patent number: 11316089Abstract: Disclosed herein is a method and apparatus that uses a brine from a well that is used to both generate electricity and recover valuable minerals present in the brine. The method and apparatus uses a hydrophobic membrane to separate water vapor from the brine to concentrate the brine that is then used to recover the minerals.Type: GrantFiled: May 18, 2020Date of Patent: April 26, 2022Assignee: Southern Research InstituteInventors: Ryan Melsert, Jay Renew
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Patent number: 11265178Abstract: Technologies are provided for clockless physically unclonable functions (PUFs) in reconfigurable devices. Embodiments of the disclosed technologies include processing circuitry configured to perform numerous operations. The operations can include receiving a challenge continuous pulse signal, and generating a response continuous pulse signal by iteratively extending the challenge continuous pulse signal in time-domain. In some configurations, the iteratively extending includes generating a next continuous pulse signal by operating on a prior continuous pulse signal according to a stretching function, and generating a second next continuous pulse width signal by operating on the next continuous pulse signal according to a folding function.Type: GrantFiled: June 10, 2019Date of Patent: March 1, 2022Assignee: SOUTHERN RESEARCH INSTITUTEInventor: Seth D. Cohen
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Publication number: 20220031817Abstract: The use of a purine nucleoside phosphorylase or nucleoside hydrolase or a vector encoding expression of one of these enzymes is detailed along with the use of a prodrug cleaved by the purine nucleoside phosphorylase or nucleoside hydrolase for the preparation of a direct injection inhibition of replicating or non-replicating targeted cells. The targeted cells do not normally express the introduced purine nucleoside phosphorylase or nucleoside hydrolase. The enzyme and prodrug are amenable to intermixing and injection as a single dose or as separate injection or administration to the targeted cells. The substance and prodrug efficacy are enhanced through exposure of the targeted cells to X-ray radiation. Administration of a prodrug regardless of administration route to the targeted cells is effective in combination with X-ray radiation therapy to kill or inhibit function of the targeted cells.Type: ApplicationFiled: October 15, 2021Publication date: February 3, 2022Applicants: The UAB Research Foundation, Southern Research InstituteInventors: William B. Parker, Eric J. Sorscher
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Patent number: 11220569Abstract: Disclosed herein is an aerogel made from a polyhydroxy benzene compound crosslinked with formaldehyde. The aerogel is dry and has a first volume and wherein the aerogel can be exposed to a liquid and be re-dried in a gas while retaining at least 70% of the first volume.Type: GrantFiled: January 14, 2019Date of Patent: January 11, 2022Assignee: SOUTHERN RESEARCH INSTITUTEInventors: William Madison Parks, Rebecca J. Boohaker, Ashish Pathak, Saibal Chakraborty
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Publication number: 20210369713Abstract: In one aspect, compounds and compositions that inhibit TXNIP expression and/or that lower hepatic glucose production and methods of identifying, making, and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with elevated TXNIP and/or elevated glucagon levels such as, for example, diabetes and associated disorders. Further provided are methods for treating hyperlipidemia or fatty liver disease, optionally associated with elevated TXNIP and/or elevated glucagon levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: July 13, 2021Publication date: December 2, 2021Applicants: SOUTHERN RESEARCH INSTITUTE, THE UAB RESEARCH FOUNDATIONInventors: Corinne E. Augelli-Szafran, Omar Moukha-Chafiq, Mark J. Suto, Anath Shalev, Lance Thielen, Junqin Chen, Gu Jing
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Patent number: 11103508Abstract: In one aspect, compounds and compositions that inhibit TXNIP expression and/or that lower hepatic glucose production and methods of identifying, making, and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with elevated TXNIP and/or elevated glucagon levels such as, for example, diabetes and associated disorders. Further provided are methods for treating hyperlipidemia or fatty liver disease, optionally associated with elevated TXNIP and/or elevated glucagon levels.Type: GrantFiled: October 31, 2018Date of Patent: August 31, 2021Assignees: SOUTHERN RESEARCH INSTITUTE, THE UAB RESEARCH FOUNDATIONInventors: Corinne E. Augelli-Szafran, Omar Moukha-Chafiq, Mark J. Suto, Anath Shalev, Lance Thielen, Junqin Chen, Gu Jing