Patents Assigned to Southern Research Institute
  • Patent number: 11447472
    Abstract: The present disclosure provides crystalline polymorphs of 5-aza-4?-thio-2?-deoxycytidine. The crystalline polymorphs may be formulated in a pharmaceutical composition, optionally in combination with an additional chemotherapeutic agent. The crystalline polymorphs are useful to treat various diseases including blood cancers, such as myelodysplastic syndrome and leukemia. A process for preparing the crystalline polymorphs of 5-aza-4?-thio-2?-deoxycytidine is also disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: July 23, 2021
    Date of Patent: September 20, 2022
    Assignees: PINOTBIO, INC., SOUTHERN RESEARCH INSTITUTE
    Inventors: Mark J. Suto, Doo Young Jung, Jin Soo Lee, Hyunyong Cho
  • Patent number: 11381224
    Abstract: Technologies are provided for generation of programmable pulse signals using inverse chaotic maps, without reliance on a clocking signal. Some embodiments of the technologies include an apparatus that can receive a sequence of bits having a defined number of bits, where the sequence of bits represent a desired continuous pulse signal having a programmable width in time-domain. The apparatus can also can receive a precursor continuous pulse signal having an arbitrary width in time-domain that fits within the dynamic range of the apparatus. The apparatus can generate the desired continuous pulse signal by transforming the precursor continuous pulse signal using the sequence of bits and an inverse chaotic map.
    Type: Grant
    Filed: June 10, 2019
    Date of Patent: July 5, 2022
    Assignee: SOUTHERN RESEARCH INSTITUTE
    Inventor: Seth D. Cohen
  • Patent number: 11316089
    Abstract: Disclosed herein is a method and apparatus that uses a brine from a well that is used to both generate electricity and recover valuable minerals present in the brine. The method and apparatus uses a hydrophobic membrane to separate water vapor from the brine to concentrate the brine that is then used to recover the minerals.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: April 26, 2022
    Assignee: Southern Research Institute
    Inventors: Ryan Melsert, Jay Renew
  • Patent number: 11265178
    Abstract: Technologies are provided for clockless physically unclonable functions (PUFs) in reconfigurable devices. Embodiments of the disclosed technologies include processing circuitry configured to perform numerous operations. The operations can include receiving a challenge continuous pulse signal, and generating a response continuous pulse signal by iteratively extending the challenge continuous pulse signal in time-domain. In some configurations, the iteratively extending includes generating a next continuous pulse signal by operating on a prior continuous pulse signal according to a stretching function, and generating a second next continuous pulse width signal by operating on the next continuous pulse signal according to a folding function.
    Type: Grant
    Filed: June 10, 2019
    Date of Patent: March 1, 2022
    Assignee: SOUTHERN RESEARCH INSTITUTE
    Inventor: Seth D. Cohen
  • Publication number: 20220031817
    Abstract: The use of a purine nucleoside phosphorylase or nucleoside hydrolase or a vector encoding expression of one of these enzymes is detailed along with the use of a prodrug cleaved by the purine nucleoside phosphorylase or nucleoside hydrolase for the preparation of a direct injection inhibition of replicating or non-replicating targeted cells. The targeted cells do not normally express the introduced purine nucleoside phosphorylase or nucleoside hydrolase. The enzyme and prodrug are amenable to intermixing and injection as a single dose or as separate injection or administration to the targeted cells. The substance and prodrug efficacy are enhanced through exposure of the targeted cells to X-ray radiation. Administration of a prodrug regardless of administration route to the targeted cells is effective in combination with X-ray radiation therapy to kill or inhibit function of the targeted cells.
    Type: Application
    Filed: October 15, 2021
    Publication date: February 3, 2022
    Applicants: The UAB Research Foundation, Southern Research Institute
    Inventors: William B. Parker, Eric J. Sorscher
  • Patent number: 11220569
    Abstract: Disclosed herein is an aerogel made from a polyhydroxy benzene compound crosslinked with formaldehyde. The aerogel is dry and has a first volume and wherein the aerogel can be exposed to a liquid and be re-dried in a gas while retaining at least 70% of the first volume.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: January 11, 2022
    Assignee: SOUTHERN RESEARCH INSTITUTE
    Inventors: William Madison Parks, Rebecca J. Boohaker, Ashish Pathak, Saibal Chakraborty
  • Publication number: 20210369713
    Abstract: In one aspect, compounds and compositions that inhibit TXNIP expression and/or that lower hepatic glucose production and methods of identifying, making, and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with elevated TXNIP and/or elevated glucagon levels such as, for example, diabetes and associated disorders. Further provided are methods for treating hyperlipidemia or fatty liver disease, optionally associated with elevated TXNIP and/or elevated glucagon levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: July 13, 2021
    Publication date: December 2, 2021
    Applicants: SOUTHERN RESEARCH INSTITUTE, THE UAB RESEARCH FOUNDATION
    Inventors: Corinne E. Augelli-Szafran, Omar Moukha-Chafiq, Mark J. Suto, Anath Shalev, Lance Thielen, Junqin Chen, Gu Jing
  • Patent number: 11103508
    Abstract: In one aspect, compounds and compositions that inhibit TXNIP expression and/or that lower hepatic glucose production and methods of identifying, making, and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with elevated TXNIP and/or elevated glucagon levels such as, for example, diabetes and associated disorders. Further provided are methods for treating hyperlipidemia or fatty liver disease, optionally associated with elevated TXNIP and/or elevated glucagon levels.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: August 31, 2021
    Assignees: SOUTHERN RESEARCH INSTITUTE, THE UAB RESEARCH FOUNDATION
    Inventors: Corinne E. Augelli-Szafran, Omar Moukha-Chafiq, Mark J. Suto, Anath Shalev, Lance Thielen, Junqin Chen, Gu Jing
  • Patent number: 11066357
    Abstract: The present disclosure is concerned with benzoannulene compounds that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, chikungunya, Venezuelan equine encephalitis, dengue, influenza, and zika, using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: December 24, 2018
    Date of Patent: July 20, 2021
    Assignee: SOUTHERN RESEARCH INSTITUTE
    Inventors: Ashish Kumar Pathak, Syed Kaleem Ahmed, Mark J. Suto, Corinne E. Augelli-Szafran
  • Patent number: 11046729
    Abstract: The present disclosure is concerned with dipeptide analogs that are capable of inhibiting TGF-? and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, methods for immunotherapy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: June 29, 2021
    Assignees: Southern Research Institute, UAB Research Foundation
    Inventors: Mark J. Suto, Vandana Gupta, Bini Mathew, Joanne Murphy-Ullrich
  • Patent number: 11040152
    Abstract: Disclosed herein is an injection device with housing that defines a channel and a first injection guide opening. The first injection guide opening enters the channel in a manner that allows a needle to penetrate a vessel in an animal with accuracy and at the same time protect the user from the needle.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: June 22, 2021
    Assignees: SOUTHERN RESEARCH INSTITUTE, THE UAB RESEARCH FOUNDATION
    Inventors: Harrison Kim, Patrick Schexnailder
  • Patent number: 11033535
    Abstract: The present disclosure is concerned with oxadiazole and thiadiazole analogs that are capable of inhibiting TGF-? and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: June 15, 2021
    Assignees: Southern Research Institute, UAB Research Foundation
    Inventors: Mark J. Suto, Vandana V. Gupta, Bini Mathew, Joanne Murphy-Ullrich
  • Patent number: 10987544
    Abstract: Systems and methods for controlling application of horizontal resistive force to a user walking on a treadmill to provide substantially constant force even if the user changes his or her relative position on the treadmill. The systems and methods can improve the user experience when force is applied while also improving user safety. The system has a cable, a motor, and a system controller. The cable can be coupled to a harness to apply a horizontal resistive force to a treadmill user, and the motor can be coupled to the cable and configured to apply a motor force to the cable. The cable can have an adjustable operative length. The system controller can have a processor communicatively coupled to the motor and configured to adjust the force applied by the motor in response to changes in cable length and a measurement of the actual force applied by the cable.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: April 27, 2021
    Assignees: SOUTHERN RESEARCH INSTITUTE, THE UAB RESEARCH FOUNDATION
    Inventor: Daniel W. Root, Jr.
  • Patent number: 10953017
    Abstract: Methods for enhancing memory and/or learning and prevent neurodegeneration by administration of certain heterocyclic and aromatic compounds are described. The methods are particularly useful for treating patients suffering from a neurodegenerative disease such as (without limitation) Alzheimer's, Parkinsons's, Lou Gehrig's (ALS) disease or memory or learning impairment. A neuronal human cell-based assay that assess NF-kB gene up-regulation using a luciferase reporter is also provided that screens for compounds useful in methods for enhancing memory or learning.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: March 23, 2021
    Assignee: SOUTHERN RESEARCH INSTITUTE
    Inventors: Maurizio Grimaldi, Judith Varady Hobrath, Subramaniam Ananthan, Joseph A. Maddry
  • Patent number: 10815264
    Abstract: The present application relates to novel nucleoside derivatives of formula (I) as claimed in claim 1, pharmaceutical compositions comprising the compounds, processes of preparation thereof, and methods of use thereof for treating cancer.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: October 27, 2020
    Assignee: Southern Research Institute
    Inventors: Cyril B. Dousson, David Dukhan, Jean-Laurent Paparin, Christophe C. Parsy
  • Patent number: 10686110
    Abstract: Disclosed herein is a method and apparatus that uses a brine from a well that is used to both generate electricity and recover valuable minerals present in the brine. The method and apparatus uses a hydrophobic membrane to separate water vapor from the brine to concentrate the brine that is then used to recover the minerals.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: June 16, 2020
    Assignee: Southern Research Institute
    Inventors: Ryan Melsert, Jay Renew
  • Patent number: 10653682
    Abstract: The present disclosure is concerned with oxadiazole and thiadiazole analogs that are capable of inhibiting TGF-? and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: May 19, 2020
    Assignees: Southern Research Institute, UAB Research Foundation
    Inventors: Mark J. Suto, Vandana V. Gupta, Bini Mathew, Joanne Murphy-Ullrich
  • Patent number: 10611733
    Abstract: Provided is a method for treating or preventing a viral infection in a subject, wherein the viral infection is from a flavivirus selected from the group consisting of Hepatitis C Virus (genotypes 1-7) and Japanese Encephalitis Virus, as well as novel compounds that are useful in the method.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: April 7, 2020
    Assignees: Sanford-Burnham Medical Research Institute, Southern Research Institute
    Inventors: Marintha L. Heil, Nicholas D. P. Cosford, Robert Ardecky, Jiwen Zou
  • Patent number: 10605789
    Abstract: A method performed by an ultrasonic inspection system includes delivering to a multilayer structure an ultrasonic pulse that sweeps through a chirp bandwidth, and receiving from the multilayer structure ultrasonic energy including a series of time-overlapping reflections of the pulse delivered to the multilayer structure from layers of the multilayer structure. The method also includes performing frequency domain processing on the ultrasonic energy to produce frequency resonance peaks respectively indicative of distinct layers of the multilayer structure, and performing time domain processing on the ultrasonic energy to compress the time-overlapping reflections into respective time-separated reflection time peaks. The method also includes displaying the frequency resonance peaks on a frequency domain plot, and displaying the reflection time peaks on a time domain plot.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: March 31, 2020
    Assignee: Southern Research Institute
    Inventor: Janelle Kay Chambers
  • Patent number: 10578702
    Abstract: An imaging phantom having a housing and a dynamic perfusion assembly positioned within the housing. The dynamic perfusion assembly permits the flow of at least one contrast agent into a non-contrast solution at a desired rate. The dynamic perfusion assembly includes a first chamber that receives at least one contrast agent and a second chamber that receives a non-contrast solution. The second chamber receives the at least one contrast agent from the first chamber at the desired rate.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: March 3, 2020
    Assignees: UAB Research Foundation, Southern Research Institute
    Inventor: Harrison Kim