Abstract: 5-Quinolinone and Imidazopyrimidine compounds are provided that are useful for inhibiting the efflux of any therapeutic agent that is a MRP1 substrate. Also provided is a method for screening to identify additional MRP1 inhibitors.
Type:
Application
Filed:
July 10, 2009
Publication date:
July 21, 2011
Applicant:
SOUTHERN RESEARCH INSTITUTE OFFICE OF COMMERCIALIZ
Inventors:
Joseph A. Maddry, Adam Keeton, Jason Whitt, Gary Piazza