Abstract: The compounds provided herein are suitable for inhibiting a virus in a patient and for treating a patient suffering from a viral infection such as an influenza virus. Also provided is a method for screening of compounds for use in treating and preventing viral infections. The assay screens compounds for activity against an influenza virus by measuring the cytopathogenic effect (CPE) of the compound on influenza infected-cells using percent cell viability as the end point.
Type:
Application
Filed:
December 28, 2009
Publication date:
February 16, 2012
Applicant:
Southern Research Institute Office of Commercialization and Intellectual Prop
Inventors:
Joseph A. Maddry, Bill Severson, Colleen B. Jonsson, James W. Noah, Diana L. Noah, Xi Chen
Abstract: Methods for treating neoplasia with a chemotherapeutic agent and radiation are provided. Radiation therapies used in conduction with a compound described herein presents a synergistic effect in the treatment of cancers. A compound of formula (I): wherein X, Y, Z, R1 and R2 are defined herein, sensitize cells making them more susceptible to radiation therapy.
Type:
Application
Filed:
April 14, 2008
Publication date:
October 23, 2008
Applicant:
Southern Research Institute Office of Commercialization and intellectual Prop