Abstract: The present disclosure is concerned with biaryl aminomaleimide compounds for the treatment of disorders associated with heme oxygenase-1 (HO-1) signaling dysfunction such as, for example, kidney diseases (e.g., chronic kidney disease, acute kidney injury). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Type:
Grant
Filed:
November 17, 2021
Date of Patent:
September 12, 2023
Assignees:
Southern Reserach Institute, The UAB Research Foundation, The United States Government as represented by the Department of Veterans Affairs
Inventors:
Mark J. Suto, Bini Mathew, Anupam Agarwal, Amie M. Traylor