Patents Assigned to Southwest Synthetic Pharmaceutical Corp., Ltd.
  • Method for preparing a statin compound by lactonization
    Patent number: 8779167
    Abstract: A method for preparing a statin compound by lactonization is disclosed, which comprises the following step: lactonizing a compound of formula II into the compound of formula I in the presence of a strong acid catalyst and a dehydrant in a first solvent, wherein Z represents H, ammonium, or a metal cations; R1 is H or C1-C6 alkyl, preferably H or CH3, R2 is CH3, OH, CH2OH, CH2OC(O)R3, CH2OR3, or COOR4, preferably CH3 or OH, R3 and R4 are independently selected from the group consisting of H and C1-C6 alkyl.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: July 15, 2014
    Assignees: Peking University Founder Group Co., Ltd., Southwest Synthetic Pharmaceutical Corp., Ltd., PKU International Healthcare Group Co., Ltd.
    Inventors: Deyin Ma, Qingkai He, Yunhui Zhang