Abstract: First cardiac signal data generated from measured heart beats of a subject is received. Characteristics of alternans occurring in the received first cardiac signal data are determined. Second cardiac signal data generated from measured heart beats of the subject after a change relating to an administration of a pharmacological agent is received. Characteristics of alternans occurring in the received second cardiac signal data are determined. The characteristics of alternans occurring in the received first cardiac signal data are compared with the characteristics of alternans occurring in the received second cardiac signal data.