Abstract: The present disclosure relates to a compound according to Formula (I) and to a method for producing the compound as well as to the use of the compound as an intermediate in the production of coated nanostructures. The present disclosure also relates to such nanostructures and to the use of such nanostructures as carriers of radionuclides as well as pharmaceutical compositions comprising such nanostructures.

Abstract: The present disclosure relates to a method of immobilizing a phenolic compound having a Mw?500 g/mol, wherein the method comprises the steps of ionizing the phenolic compound by subjecting it to a base; and contacting, under agitation, the ionized phenolic compound with a cross-linked resin comprising the functionality of —C(?O)—CHXCH2R, wherein X is chosen from the group consisting of Br, Cl, I, CN, OMs, OTs, or OTf, and R is H, CH3 or an branched or unbranched alkyl having 1 to 8 carbon atoms, in the presence of a base and a solvent. The present disclosure also relates to a method of removing phenolic compounds having a Mw?500 g/mol from a composition comprising compounds having at least one alkoxy silane group. The present disclosure also relates to the use of a method according to the present disclosure as well as to a product, from which at least one phenolic compound having a Mw?500 g/mol has been removed by a method according to the present disclosure.

Abstract: The present disclosure relates to a plurality of globular nanostructures.

Abstract: The present disclosure relates to a plurality of nanostructures having an average hydrodynamic diameter between 20 to 50 nm, wherein each nanostructure is a polymeric nanostructure comprising a central part, an anchoring layer surrounding the central part and a coating layer surrounding the anchoring layer. The present disclosure also relates to such a plurality of nanostructures for use as a medicament, especially for use in the treatment of cancer and/or imaging, as well as the use such nanostructures as carriers of radionuclides. The present disclosure also relates to a method for radiolabeling such nanostructures with a multivalent cationic radionuclide and to a kit.

Abstract: The present disclosure relates to a plurality of globular nanostructures, having a dispersity between 1 and 1.8 and a volume average hydrodynamic diameter of 13 nm to 90 nm; wherein each nanostructure comprises a polymer framework of monomer residues, wherein the average number of bonds from each monomer residue is in the range of from 3.0 up to but not including 6.0; wherein at least 90% of the monomer residues comprise two geminal chelating groups, each chelating group independently being PO(OR1)(OR2); wherein R1 and R2 are independently selected from the group consisting of a negative charge and H; and denotes an internal bond in the monomer residue. The present disclosure also relates to a method of producing such nanostructures, to the use of such nanostructures as well as to a pharmaceutical composition comprising such nanostructures.

Abstract: The present application relates to a chemical compound comprising an aromatic core, or a carbocyclic, non-aromatic, core, wherein the aromatic core is a benzene ring or a biphenyl; the carbocyclic, non-aromatic core is a 5 to 7 membered ring. The core has covalently attached thereto: at least two anchoring groups, each anchoring group comprising an activated silane group, wherein the anchoring groups have the following general formula -A-(CH2)nSiY3 wherein A is a covalent bond or O, “n” is an integer from 1 to 3, and Y is independently a methoxy group or an ethoxy group; and at least one hydrophilic group extending from the core, the hydrophilic group comprising one or more hydrophilic polymer residues with a molecular composition of (aO+bN)/(cC+dS+eSi+fP)>0.

Abstract: Disclosed herein are globular nanostructures having a hydrodynamic diameter (Dh) of 8-100 nm comprising a central part and a peripheral part, wherein said central part has a calculated diameter (Dc) of 6-90 nm and said peripheral part has an estimated thickness (Tp) so that Dh=Dc+2Tp, wherein said central part comprises: (i) a crosslinked polymeric framework comprising monomer residues wherein at least 30% by number of the monomer residues have crosslinked thereby forming the crosslinked polymeric framework and/or (ii) a branched polymeric framework comprising monomer residues wherein the number of branch points is at least 30% of the number of monomer residues, wherein said central part comprises chelating groups of which at least 4 allow chelation of at least one multiply charged cation, wherein said chelating groups are independently selected from the group consisting of —COOR1, —P?O(OR1)(OR2), and —S(?O)2OR1, wherein R1 and R2 are independently selected from the group consisting of a negative charge, H, a