Abstract: Pharmaceutical composition of ibuprofen for injection that comprises an aqueous solution of ibuprofen and trometamol. These compositions display a minimal loss of active principle and acceptable increase of impurities after autoclaving, properties that have been demonstrated in various types of containers, such as containers made of plastics such as polypropylene, PVC and polyethylene, as well as in glass containers. These compositions, after undergoing autoclaving, still comply with all the relevant technical specifications of the European Pharmacopoeia and of the USP.
Type:
Grant
Filed:
May 18, 2011
Date of Patent:
August 25, 2015
Assignee:
Spain Pharma S.A.
Inventors:
Ignacio Ortúzar Andéchaga, Mario Ortúzar Gutiérrez
Abstract: Pharmaceutical composition of ibuprofen for injection that comprises an aqueous solution of ibuprofen and trometamol. These compositions display a minimal loss of active principle and acceptable increase of impurities after autoclaving, properties that have been demonstrated in various types of containers, such as containers made of plastics such as polypropylene, PVC and polyethylene, as well as in glass containers. These compositions, after undergoing autoclaving, still comply with all the relevant technical specifications of the European Pharmacopoeia and of the USP.
Type:
Application
Filed:
May 18, 2011
Publication date:
September 5, 2013
Applicant:
SPAIN PHARMA, S.A.
Inventors:
Ignacio Ortúzar Andéchaga, Mario Ortúzar Gutiérrez