Abstract: In an illustrative embodiment, methods and system for increasing coagulation potential and/or triggering a higher platelet activation rate in a subject via auricular neurostimulation include contacting skin of the subject with one or more therapeutic electrodes, each electrode positioned in a respective region of nerve structures of the auriculotemporal nerve (ATN), nerve structures connected to the ATN, nerve structures of the auricular branch of the vagus nerve (ABVN), or nerve structures connected to the ABVN, applying, to the electrodes, one or more stimulation patterns.

Abstract: In an illustrative embodiment, systems and methods for inhibiting, reducing or eliminating motion sickness using a neuromodulation device configured to be worn on a subject's head and a controller configured to deliver therapeutic stimulation pulses for providing motion sickness therapy involve delivering, by the controller, a first series of stimulation pulses to first electrode(s) positioned on or near the subject's ear in a first tissue region to modulate peripheral activity, and delivering, by the controller, a second series of stimulation pulses to second electrode(s) positioned on or near the subject's ear in a second tissue region t to modulate one or more areas in the subject's brain stem.

Abstract: In an illustrative embodiment, a wearable auricular stimulator includes a flexible body adapted to be worn at least partially around an auricle of a wearer, including an exterior for positioning in contact with a wearer's skin, and an interior for supporting a three-dimensional (3D) circuitry layout, including traces deposited on surfaces of the interior of the flexible body, electrodes for delivering electrical stimulation therapy to the wearer via a skin-facing side of the flexible body, and electronic component(s) electrically connected with the electrodes and the traces, the electronic components including a processing circuitry element for delivering electrical stimulation treatment(s) via the electrodes.

Abstract: In an illustrative embodiment, methods and systems for increasing coagulation potential and/or triggering a higher platelet activation rate in a subject via auricular neurostimulation include contacting skin of the subject with one or more therapeutic electrodes, each electrode positioned in a respective region of nerve structures of the auriculotemporal nerve (ATN), nerve structures connected to the ATN, nerve structures of the auricular branch of the vagus nerve (ABVN), or nerve structures connected to the ABVN, applying, to the electrodes, one or more stimulation patterns.

Abstract: In an illustrative embodiment, methods and system for increasing coagulation potential and/or triggering a higher platelet activation rate in a subject via auricular neurostimulation include contacting skin of the subject with one or more therapeutic electrodes, each electrode positioned in a respective region of nerve structures of the auriculotemporal nerve (ATN), nerve structures connected to the ATN, nerve structures of the auricular branch of the vagus nerve (ABVN), or nerve structures connected to the ABVN, applying, to the electrodes, one or more stimulation patterns.

Abstract: In an illustrative embodiment, systems and methods for inhibiting, reducing or eliminating motion sickness using a neuromodulation device configured to be worn on a subject's head and a controller configured to deliver therapeutic stimulation pulses for providing motion sickness therapy involve delivering, by the controller, a first series of stimulation pulses to first electrode(s) positioned on or near the subject's ear in a first tissue region to modulate peripheral activity, and delivering, by the controller, a second series of stimulation pulses to second electrode(s) positioned on or near the subject's ear in a second tissue region t to modulate one or more areas in the subject's brain stem.

Abstract: In an illustrative embodiment, a wearable auricular stimulator includes a flexible body adapted to be worn at least partially around an auricle of a wearer, including an exterior for positioning in contact with a wearer's skin, and an interior for supporting a three-dimensional (3D) circuitry layout, including traces deposited on surfaces of the interior of the flexible body, electrodes for delivering electrical stimulation therapy to the wearer via a skin-facing side of the flexible body, and electronic component(s) electrically connected with the electrodes and the traces, the electronic components including a processing circuitry element for delivering electrical stimulation treatment(s) via the electrodes.

Abstract: In an illustrative embodiment, systems and methods for providing antiemetic therapy through neuromodulation include positioning a first electrode against or at least partially into a first tissue region on or surrounding a subject's ear such that the first electrode is on, over, or adjacent to one or more first neural structures, positioning a second electrode against or at least partially into a second tissue region on or surrounding the ear such that the second electrode is on, over, or adjacent to one or more second neural structures, delivering a first series of stimulation pulses to the first electrode for modulating peripheral activity via modulating central neural autonomic structures, and delivering a second series of stimulation pulses to the second electrode for increasing availability of central norepinephrine.

Abstract: In an illustrative embodiment, an apparatus for controlling or reducing stress levels includes an ear-mounted device having an earpiece for positioning over a wearer's ear contacting tissue regions surrounding the ear, and electrodes for delivering non-piercing neurostimulation, with first electrode(s) arranged on a first surface of the earpiece to contact a first tissue region, and second electrode(s) are arranged on a second surface to contact a second tissue region. The auricular branch of the vagus nerve or the auriculotemporal nerve is situated beneath the first tissue region. The apparatus includes a controller to deliver therapeutic stimulation pulses via the stimulation device, where the pulses in combination with the positioning of the first electrode(s) and the second electrode(s) are configured to modulate the activity ratio between the sympathetic nervous system and the parasympathetic nervous system, thereby increasing vagal tone.

Abstract: In an illustrative embodiment, a connector for interfacing a flexible circuitry device with an apparatus includes a housing having a lower housing portion and an upper housing portion with a button region for a button, circuit board(s) including contact(s) for interfacing with corresponding contact(s) of an I/O section of flexible circuitry, retention feature(s) for frictionally retaining the I/O section against the contact(s) of the circuit board(s), and a cable interface. When the button is in a retain position, the button creates a downward force on the retention feature(s) toward the lower housing portion, thereby frictionally retaining the I/O section of the flexible circuitry, and, when the button is in a release position, the retention feature(s) is displaced in a direction of the upper housing portion, thereby creating or widening an aperture for insertion of the I/O section.

Abstract: In an illustrative embodiment, systems and methods for providing antiemetic therapy through neuromodulation include positioning a first electrode against or at least partially into a first tissue region on or surrounding a subject's ear such that the first electrode is on, over, or adjacent to one or more first neural structures, positioning a second electrode against or at least partially into a second tissue region on or surrounding the ear such that the second electrode is on, over, or adjacent to one or more second neural structures, delivering a first series of stimulation pulses to the first electrode for modulating peripheral activity via modulating central neural autonomic structures, and delivering a second series of stimulation pulses to the second electrode for increasing availability of central norepinephrine.

Abstract: In an illustrative embodiment, methods and systems for attenuating effect(s) associated with reduction or cessation of substance use by an individual include providing a neurostimulation delivery system including a neurostimulation device having a first portion including a first electrode configured to electrically stimulate auricular branch(es) of the vagus nerve, and a second portion including a second electrode configured to electrically stimulate branch(es) of the auriculotemporal nerve, and a pulse generator including circuitry configured to deliver therapeutic stimulation pulses to the first and second electrodes. Methods and systems include positioning the neurostimulation device for administration of the neurostimulation treatment, whereby the first electrode is disposed on, over or adjacent to auricular branch(es) of the vagus nerve, and the second electrode is disposed on, over or adjacent to branch(es) of the auriculotemporal nerve, and administering the neurostimulation treatment.

Abstract: Systems and methods for treating cognitive dysfunction and/or depression using transcutaneous auricular neurostimulation therapy may include positioning a wearable neurostimulation device about the ear of the patient, connecting the wearable neurostimulation device, to a pulse generator, and delivering a first series of stimulation pulses to at least one first electrode, the first series being configured to increase monoamine neurotransmitter availability, and delivering a second series of stimulation pulses to at least one second electrode, the second series being configured to upregulate opioid receptor agonists.

Abstract: Systems and methods for reducing pulmonary inflammation and/or increasing bronchial compliance in a patient utilize transcutaneous stimulation of neural structures in a region of an ear of a patient delivered by an auricular stimulation device having an in-ear component with a first electrode disposed in a patient's ear and an earpiece component with a second electrode placed around the auricle. A pulse generator may control delivery of therapy by delivering both a first series of stimulation pulses to the first electrode for stimulating a first neural structure(s) and a second series of stimulation pulses to the second electrode for stimulating second neural structure(s). The first and second electrodes are in non-piercing contact with tissue on and/or surrounding the ear. The systems and methods may be used to treat viral or bacteria infections, such as SARS, MERS, or COVID-19.

Abstract: A treatment system and method for inducing endogenous release of peptides is provided including a concha apparatus including a first electrode in contact with vagal related neural structures; an earpiece connected to the concha apparatus by a first connector, the earpiece including a PCB layer including a second electrode configured to be in contact with a neural structure related to the auriculotemporal nerve, and at least another electrode configured to be in contact with or in proximity to neural structures related to the great auricular nerve and/or its branches and/or the lesser occipital nerve and/or its branches, and an adhesive configured to secure the electrodes on the earpiece to the skin; and a pulse generator connected to the earpiece by a second connector, the pulse generator including circuitry in communication with the first electrode of the concha apparatus, the second electrode and the at least another electrode of the earpiece.

Abstract: A treatment system and method for inducing endogenous release of peptides is provided including a concha apparatus including a first electrode in contact with vagal related neural structures; an earpiece connected to the concha apparatus by a first connector, the earpiece including a PCB layer including a second electrode configured to be in contact with a neural structure related to the auriculotemporal nerve, and at least another electrode configured to be in contact with or in proximity to neural structures related to the great auricular nerve and/or its branches and/or the lesser occipital nerve and/or its branches, and an adhesive configured to secure the electrodes on the earpiece to the skin; and a pulse generator connected to the earpiece by a second connector, the pulse generator including circuitry in communication with the first electrode of the concha apparatus, the second electrode and the at least another electrode of the earpiece.