Patents Assigned to Spark Biopharma, Inc.
  • Phosphor-tetrazine compound and use thereof
    Patent number: 11584749
    Abstract: The present invention relates to a novel phosphor-tetrazine and a use thereof and, more particularly, provides a novel compound having high fluorescence amplification efficiency in various wavelength ranges by using a compound having a novel core skeleton called tert-butyl (3-(7-(6-methyl-1,2,4,5-tetrazin-3-yl)-3-oxo-9-phenyl-1H-pyrrolo[3,4-b]indolizin-2(3H)-yl)propyl)carbamate.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: February 21, 2023
    Assignees: Spark Biopharma, Inc., Seoul National University R&DB Foundation
    Inventors: Seung Bum Park, Young Jun Lee
  • Pyrimidine derivative compound, pharmaceutically acceptable salt thereof, preparation process thereof, and pharmaceutical composition using the same
    Patent number: 11535627
    Abstract: The present invention is related to a novel pyrimidine derivative compound or a pharmaceutically acceptable salt thereof, a process for preparing the same, and a pharmaceutical composition using the same.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: December 27, 2022
    Assignee: Spark Biopharma, Inc.
    Inventors: Seung Bum Park, Jonghoon Kim
  • Method for target protein identification using thermal stability shift-based fluorescence difference in two-dimensional gel electrophoresis
    Patent number: 11105813
    Abstract: The present invention relates to a method for identifying a target protein using a thermal stability shift-based fluorescence difference in two-dimensional gel electrophoresis, and more specifically, a method for identifying a protein, which is a target of a specific drug, by analyzing, by means of a fluorescence difference in two-dimensional gel electrophoresis, a thermal stability shift in the protein when a specific drug, preferably a bioactive molecule, binds to the target protein.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: August 31, 2021
    Assignee: Spark Biopharma, Inc.
    Inventors: Seung Bum Park, Han Kum Park
  • Benzopyranyl tetracycle compound and pharmaceutical composition having excellent anti-inflammatory effect comprising the same
    Patent number: 10160766
    Abstract: The present invention relates a novel compound represented by the following Formula 3 or Formula 5, and a pharmaceutical composition having superior anti-inflammatory effect comprising the above. The above compound inhibits the translocation of HMGB1 form nucleus to cytosol, and then has remarkable effect of treating or preventing inflammatory disease, especially sepsis.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: December 25, 2018
    Assignees: Spark Biopharma, Inc., Seoul National University R&DB Foundation
    Inventors: Seung Bum Park, Wan Sang Cho, Ja Young Koo