Patents Assigned to Spartan Bioscience Inc.
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Patent number: 10391498Abstract: The present disclosure provides, among other things, systems for nucleic acid amplification. Provided systems for nucleic acid amplification substantially irreversibly seal the contents of a nucleic acid amplification reaction vessel. Provided systems reduce amplification contamination, for example amplification carryover contamination. Provided systems reduce amplification of spurious nucleic acids or amplification products. The present disclosure also provides methods of amplifying nucleic acids. The present disclosure also provides methods of amplifying nucleic acids using provided systems. Provided systems and methods are useful for nucleic acid amplification.Type: GrantFiled: December 7, 2016Date of Patent: August 27, 2019Assignee: Spartan Bioscience Inc.Inventors: Chris Harder, Michael Buxton, Lawrence Dickson, John Lem, Joel Koscielski, Derek Glennie
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Patent number: 9593369Abstract: The present disclosure provides methods, systems, and apparatuses for collecting and/or amplifying nucleic acids. In general, provided methods, systems, and apparatuses involve contacting a sample including a nucleic acid with a nucleic acid amplification reagent without purification of nucleic acids from the sample.Type: GrantFiled: October 4, 2012Date of Patent: March 14, 2017Assignee: Spartan Bioscience Inc.Inventors: Kelly Jackson, Chris Harder, Adam Michael Damry, Paul Lem
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Patent number: 8945880Abstract: The thermal cycling system for performing a biological reaction at two or more different temperatures comprises: a) a heat source for setting at a fixed temperature; b) a reaction vessel containing material upon which the biological reaction is to be performed; c) mechanically-operable structure for altering the relative position of the heat source and the reaction vessel so that reaction vessel first achieves and maintains a desired first temperature in the reaction vessel for starting the carrying out of the biological reaction, and then for altering the relative position of the heat source and the reaction vessel so that the reaction vessel then achieves and maintains a second temperature for continuing the carrying out of the biological reaction on the biological material, and d) temperature-sensing structure operatively associated with the reaction vessel for controlling the altering of the relative position of the heat source and the reaction vessel so that the reaction vessel achieves and maintains theType: GrantFiled: July 29, 2009Date of Patent: February 3, 2015Assignee: Spartan Bioscience, Inc.Inventors: Martin Cloake, Chris Harder, Alan Shayanpour, Michael Perreault, Paul Lem
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Publication number: 20140335520Abstract: The present disclosure provides methods, systems, and apparatuses for collecting and/or amplifying nucleic acids. In general, provided methods, systems, and apparatuses involve contacting a sample including a nucleic acid with a nucleic acid amplification reagent without purification of nucleic acids from the sample.Type: ApplicationFiled: October 4, 2012Publication date: November 13, 2014Applicant: Spartan Bioscience, Inc.Inventors: Kelly Jackson, Chris Harder, Adam Michael Damry, Paul Lem
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Patent number: 8735104Abstract: Methods and apparatus are described for nucleic acid analysis of swab samples without the need for purification.Type: GrantFiled: March 31, 2011Date of Patent: May 27, 2014Assignee: Spartan Bioscience Inc.Inventors: Chris Harder, Kelly Jackson, Samantha Prevost, Hannah Bernatchez, Paul Lem, Martin Cloake, Ningke Kuang, Colin Davis
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Patent number: 8528777Abstract: A reaction tube for use in performing the Polymerase Chain Reaction (PCR) in a thermal cycler, is provided herein such reaction tube includes a hollow tube of heat conducting synthetic plastics material having an open top and a flat bottom formed of an optically-clear material. Such reaction tube also includes a solid plug cap nesting within said hollow tube and to provide a minimized void volume within the hollow tube and to minimize evaporation and condensation of the biological fluid.Type: GrantFiled: April 4, 2010Date of Patent: September 10, 2013Assignee: Spartan Bioscience Inc.Inventors: Chris Harder, Martin Cloake, Michel Perreault, Paul Lem, Alan Shayanpour
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Publication number: 20100075296Abstract: A thermal cycling system and method are provided herein, The thermal cycling system for performing a biological reaction at two or more different temperatures comprises: a) a heat source for setting at a fixed temperature; b) a reaction vessel containing material upon which the biological reaction is to be performed; c) mechanically-operable means for altering the relative position of the heat source and the reaction vessel so that reaction vessel first achieves and maintains a desired first temperature in the reaction vessel for starting the carrying out of the biological reaction, and then for altering the relative position of the heat source and the reaction vessel so that reaction vessel then achieves and maintains a second temperate for continuing the carrying out of the biological reaction on the biological material, and d) temperature-sensing means operatively associated with the reaction vessel for controlling the altering of the relative position of the heat source and the reaction vessel so that theType: ApplicationFiled: July 29, 2009Publication date: March 25, 2010Applicant: Spartan Bioscience inc.Inventors: Martin Cloake, Chris Harder, Alan Shayanpour, Michael Perreault, Paul Lem
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Patent number: 7466908Abstract: A temperature cycling system (10, 110) is provided for repeatedly heating and cooling a reaction mixture (16). The system (10, 110) includes a first heater (27) and a second heater (28) each movable between a first orientation in which the first or second heater (27, 28) affects the temperature of the reaction mixture (16) and a second orientation in which the first or second heater (27, 28) does not substantially affect the temperature of the reaction mixture (16). During temperature cycling, the second heater (28) is in the second orientation when the first heater (27) is in the first orientation, and the second heater (28) is in the first orientation when the first heater (27) is in the second orientation.Type: GrantFiled: April 15, 2005Date of Patent: December 16, 2008Assignee: Spartan Bioscience Inc.Inventors: Paul Lem, John Lem, Jamie Spiegelman
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Publication number: 20080275229Abstract: The speed of a nucleic acid amplification reaction, such as the Polymerase Chain Reaction (PCR), can be increased by setting the temperature of heat sources above and below the desired denaturation, annealing, and extension temperatures. The reaction mixture is only contacted with the heat sources long enough for the desired temperatures to be reached.Type: ApplicationFiled: October 19, 2007Publication date: November 6, 2008Applicant: Spartan Bioscience, Inc.Inventors: Paul Lem, Sebastien Fournier, Caitlin Ritz, Chris Harder, Alan Shayanpour