Abstract: The disclosure encompasses systems and methods for performing high temperature and high humidity curing of tablets using air flow delivered from a recirculating air handler to a pan coater of a tablet coating device. The recirculating air handler may be integrated into a preexisting tablet coating device so that the air flow may be delivered by the preexisting air handler or by the recirculating air handler as desired.
Abstract: The present disclosure provides pharmaceutical compositions that provide immediate release of active ingredients and have abuse deterrent properties. In particular, the pharmaceutical compositions comprise at least one pharmaceutically active ingredient, at least one non-cellulose polysaccharide, at least one hydrophilic gelling polymer, and an effervescent system.
Type:
Grant
Filed:
July 1, 2015
Date of Patent:
April 4, 2023
Assignee:
SpecGX LLC
Inventors:
Alex Micka, Kai Feng, Tsz Chung Lai, Jonathan Gaik
Abstract: The present disclosure provides pharmaceutical compositions that provide immediate release of active ingredients and have abuse deterrent properties. In particular, the pharmaceutical compositions comprise at least one pharmaceutically active ingredient, at least one non-cellulose polysaccharide, at least one hydrophilic gelling polymer, and an effervescent system.
Type:
Grant
Filed:
August 11, 2020
Date of Patent:
February 21, 2023
Assignee:
SpecGX LLC
Inventors:
Alex Micka, Kai Feng, Tsz Chung Lai, Jonathan Gaik
Abstract: The present disclosure provides pharmaceutical compositions that provide immediate release of active ingredients and have abuse deterrent properties. In particular, the pharmaceutical compositions comprise at least one pharmaceutically active ingredient, at least one non-cellulose polysaccharide, at least one hydrophilic gelling polymer, and an effervescent system.
Type:
Grant
Filed:
June 7, 2018
Date of Patent:
December 6, 2022
Assignee:
SpecGX LLC
Inventors:
Alex Micka, Kai Feng, Tsz Chung Lai, Jonathan Gaik
Abstract: Capsule dosage forms that provide immediate release of active ingredients and have abuse deterrent properties. In particular, the dosage forms comprise at least one pharmaceutically active ingredient, a combination of hydrophilic gelling polymers, at least one organic acid, and at least one disintegrant.
Type:
Grant
Filed:
September 18, 2019
Date of Patent:
October 25, 2022
Assignee:
SpecGX LLC
Inventors:
Tsz Chung Lai, Rebecca Sue Walker, Chirag Patel, Jaehan Park
Abstract: The present disclosure provides compositions having different dissolution profiles. In particular, the compositions are formulated by adjusting the types and/or amounts of excipients and/or surfactants, and the compositions are prepared by spray drying processes.
Type:
Grant
Filed:
May 27, 2015
Date of Patent:
October 11, 2022
Assignee:
SpecGX LLC
Inventors:
Joseph M. Davis, Robert C. Cuca, Edward J. Beasley
Abstract: Extended release, abuse deterrent dosage forms comprising crush-resistant controlled-release particles that provide abuse deterrent properties to the dosage forms. The crush-resistant controlled-release particles, which comprise plastic/elastic polymers and at least one active pharmaceutical ingredient (API) or a pharmaceutically acceptable salt thereof, are prepared by a hot melt extrusion process.
Type:
Grant
Filed:
March 13, 2020
Date of Patent:
September 20, 2022
Assignee:
SpecGX LLC
Inventors:
Jonathan Gaik, Jaehan Park, Ryan Lathrop, Gary Nichols, John Schallom
Abstract: The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of alpha, beta unsaturated ketone compounds present as impurities in morphinan 6 one products or reaction mixtures including morphinan 6 one compounds by treatment with a sulfur-containing compound.
Type:
Application
Filed:
November 29, 2021
Publication date:
March 17, 2022
Applicant:
SpecGx LLC
Inventors:
Henry J. Buehler, William E. Dummitt, Anthony Mannino, Dennis C. Aubuchon, Hong Gu
Abstract: Pharmaceutical compositions comprising at least one active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof, at least one hydrophilic plastomer, at least one hydrophilic elastomer, and at least one deliquescent plasticizer, wherein the pharmaceutical compositions provide extended release of the API and have abuse deterrent properties. Methods for preparing the pharmaceutical compositions in which the components of the composition are humidified such that the deliquescent plasticizer deliquesces, thereby plasticizing the hydrophilic polymers.
Type:
Grant
Filed:
October 14, 2019
Date of Patent:
August 24, 2021
Assignee:
SpecGX LLC
Inventors:
Brad L. Gower, Carlos H. Castaneda, Jae Han Park, Clifford J. Herman
Abstract: The disclosure encompasses systems and methods for performing high temperature and high humidity curing of tablets using air flow delivered from a recirculating air handler to a pan coater of a tablet coating device. The recirculating air handler may be integrated into a preexisting tablet coating device so that the air flow may be delivered by the preexisting air handler or by the recirculating air handler as desired.
Abstract: A pharmaceutical composition comprising at least one active pharmaceutical ingredient (API) or a pharmaceutically acceptable salt thereof, a glucomannan, a first polyalkylene oxide having an average molecular weight of no more than 300,000, and a second polyalkylene oxide having an average molecular weight of at least 1,000,000 and methods of making. The pharmaceutical composition provides extended release of the API and has abuse deterrent features.
Type:
Grant
Filed:
January 27, 2017
Date of Patent:
July 20, 2021
Assignee:
SpecGX LLC
Inventors:
Brad L. Gower, Jae Han Park, Clifford J. Herman, Tsz Chung Lai, Kai Feng
Abstract: Processes for preparing acetylated amphetamine derivatives and, in particular, processes for preparing L-lysine-D-amphetamine dimesylate from D-amphetamine salts.
Type:
Grant
Filed:
November 27, 2018
Date of Patent:
February 23, 2021
Assignee:
SpecGX LLC
Inventors:
Brian Orr, Kevin Roesch, Joel McClenaghan
Abstract: Provided herein are processes for forming sufentanil citrate from sufentanil base. One process comprises forming sufentanil citrate in the presence of a polar non-aqueous solvent. Other processes comprise forming sufentanil citrate in the presence of water.
Type:
Grant
Filed:
January 22, 2019
Date of Patent:
January 26, 2021
Assignee:
SpecGX LLC
Inventors:
George Helmut Klemm, Brian Orr, Joel McClenaghan
Abstract: The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of alpha, beta unsaturated ketone compounds present as impurities in morphinan 6 one products or reaction mixtures including morphinan 6 one compounds by treatment with a sulfur-containing compound.
Type:
Application
Filed:
July 13, 2020
Publication date:
October 29, 2020
Applicant:
SpecGx LLC
Inventors:
Henry J. Buehler, William E. Dummitt, Anthony Mannino, Dennis C. Aubuchon, Hong Gu
Abstract: Extended release, abuse deterrent dosage forms comprising crush-resistant controlled-release particles that provide abuse deterrent properties to the dosage forms. The crush-resistant controlled-release particles, which comprise plastic/elastic polymers and at least one active pharmaceutical ingredient (API) or a pharmaceutically acceptable salt thereof, are prepared by a hot melt extrusion process.
Type:
Grant
Filed:
March 21, 2017
Date of Patent:
April 21, 2020
Assignee:
SpecGX LLC
Inventors:
Jonathan Gaik, Jaehan Park, Ryan Lathrop, Gary Nichols, John Schallom
Abstract: The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of alpha, beta unsaturated ketone compounds present as impurities in morphinan 6 one products or reaction mixtures including morphinan 6 one compounds by treatment with a sulfur-containing compound.
Type:
Application
Filed:
August 23, 2019
Publication date:
December 19, 2019
Applicant:
SpecGx LLC
Inventors:
Henry J. Buehler, William E. Dummitt, Anthony Mannino, Dennis C. Aubuchon, Hong Gu
Abstract: Pharmaceutical compositions comprising at least one active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof, at least one hydrophilic plastomer, at least one hydrophilic elastomer, and at least one deliquescent plasticizer, wherein the pharmaceutical compositions provide extended release of the API and have abuse deterrent properties. Methods for preparing the pharmaceutical compositions in which the components of the composition are humidified such that the deliquescent plasticizer deliquesces, thereby plasticizing the hydrophilic polymers.
Type:
Grant
Filed:
January 31, 2017
Date of Patent:
November 26, 2019
Assignee:
SpecGX LLC
Inventors:
Brad L. Gower, Carlos H. Castaneda, Jae Han Park, Clifford J. Herman
Abstract: The disclosure encompasses systems and methods for performing high temperature and high humidity curing of tablets using air flow delivered from a recirculating air handler to a pan coater of a tablet coating device. The recirculating air handler may be integrated into a preexisting tablet coating device so that the air flow may be delivered by the preexisting air handler or by the recirculating air handler as desired.
Abstract: Provided herein are processes for forming sufentanil citrate from sufentanil base. One process comprises forming sufentanil citrate in the presence of a polar non-aqueous solvent. Other processes comprise forming sufentanil citrate in the presence of water.
Type:
Grant
Filed:
May 25, 2016
Date of Patent:
March 12, 2019
Assignee:
SpecGX LLC
Inventors:
George Helmut Klemm, Brian Orr, Joel McClenaghan