Abstract: Rare earth metal compounds, particularly lanthanum, cerium, and yttrium, are formed as porous particles and are effective in binding metals, metal ions, and phosphate. A method of making the particles and a method of using the particles is disclosed. The particles may be used in the gastrointestinal tract or the bloodstream to remove phosphate or to treat hyperphosphatemia in mammals. The particles may also be used to remove metals from fluids such as water.
Type:
Grant
Filed:
January 7, 2014
Date of Patent:
October 7, 2014
Assignee:
Spectrum Pharmaceuticals, Inc.
Inventors:
Rudi E. Moerck, Timothy Malcome Spitler, Edward A. Schauer, Jan Prochazka
Abstract: Therapeutic compositions comprising an indoloquinone compound and various bladder cancer treatments and methods are disclosed. More specifically, bladder cancer treatments include the intravesical administration of apaziquone immediately following transurethral resection. Also disclosed are therapeutic compositions comprising an indoloquinone compound and a formulation vehicle. The formulation vehicle improves the solubility and stability of the indoloquinone compound. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.
Type:
Application
Filed:
February 5, 2014
Publication date:
September 25, 2014
Applicant:
Spectrum Pharmaceuticals, Inc.
Inventors:
Bastiaan Nuijen, Ernie Pfadenhauer, Jos H. Beijnen, Luigi Lenaz, Shanta Chawla, Mario Beer
Abstract: The present invention provides topical formulations containing a vitamin K analog, e.g., menadione, that deliver a uniform, therapeutically effective concentration of the vitamin K analog to the skin in a vehicle which is stable, non-irritating, non-drying and cosmetically acceptable. These topical formulations are useful for the treatment and prevention of dermatological conditions associated with inflammation, particularly, dermatological conditions resulting from anti-EGFR therapies.
Type:
Grant
Filed:
March 12, 2009
Date of Patent:
August 26, 2014
Assignee:
Spectrum Pharmaceuticals, Inc.
Inventors:
Christopher G. Salentine, Kieran O'Donoghue
Abstract: Rare earth metal compounds, particularly lanthanum, cerium, and yttrium, are formed as porous particles and are effective in binding metals, metal ions, and phosphate. A method of making the particles and a method of using the particles is disclosed. The particles may be used in the gastrointestinal tract or the bloodstream to remove phosphate or to treat hyperphosphatemia in mammals. The particles may also be used to remove metals from fluids such as water.
Type:
Application
Filed:
January 7, 2014
Publication date:
June 12, 2014
Applicant:
SPECTRUM PHARMACEUTICALS, INC.
Inventors:
Rudi E. Moerck, Timothy Malcome Spitler, Edward A. Schauer, Jan Prochazka
Abstract: The present invention is a method of producing a lanthanum carbonate hydroxide or lanthanum oxycarbonate which has improved properties. The method involves the use of a water soluble lanthanum and a water soluble non-alkali metal carbonate or bicarbonate. The resulting material can be used as a phosphate binder individually or for treating patients with hyperphosphatemia.
Type:
Application
Filed:
December 12, 2013
Publication date:
June 12, 2014
Applicant:
SPECTRUM PHARMACEUTICALS, INC.
Inventors:
Ashok Yeshwant Gore, Milind Dixit, Ravichandran Mahalingam, Edward A. Schauer, Matthew Stewart, Rajendra Tandale, Ramsharan Singh
Abstract: The present specification discloses tetrahydroindolone derivatives or analogues and methods for treating cognitive/attention deficit disorders using such tetrahydroindolone derivatives and analogues.
Type:
Grant
Filed:
February 19, 2013
Date of Patent:
May 27, 2014
Assignee:
Spectrum Pharmaceuticals, Inc.
Inventors:
Alvin J. Glasky, David B. Fick, David R. Helton
Abstract: Methods, compositions and articles of manufacture for contributing to the treatment of cancers, including solid tumors, are disclosed. The methods, compositions and articles of manufacture can utilize an endothelin B agonist (ETB) to enhance the delivery and resulting efficacy of a chemotherapeutic agent.
Type:
Grant
Filed:
December 11, 2012
Date of Patent:
May 20, 2014
Assignees:
Spectrum Pharmaceuticals, Inc., The Board of Trustees of the University of Illinois
Abstract: Rare earth metal compounds, particularly lanthanum, cerium, and yttrium, are formed as porous particles and are effective in binding metals, metal ions, and phosphate. A method of making the particles and a method of using the particles is disclosed. The particles may be used in the gastrointestinal tract or the bloodstream to remove phosphate or to treat hyperphosphatemia in mammals. The particles may also be used to remove metals from fluids such as water.
Type:
Grant
Filed:
December 21, 2009
Date of Patent:
May 6, 2014
Assignee:
Spectrum Pharmaceuticals, Inc.
Inventors:
Rudi E. Moerck, Timothy Malcome Spitler, Edward A Schauer, Jan Prochazka
Abstract: The present specification provides compositions comprising a thioxanthone-based autophagy inhibitor and/or a cancer therapeutic autophagy inducing compound, pharmaceutical kits comprising these compositions, and methods of treating cancer using such compounds, compositions and kits. Additionally, the present specification provides methods of treating cancer using a thioxanthone-based autophagy inhibitor and a radiotherapy.
Type:
Application
Filed:
August 6, 2013
Publication date:
April 17, 2014
Applicant:
SPECTRUM PHARMACEUTICALS, INC.
Inventors:
Steffan Nawrocki, Jennifer Carew, Guru Reddy
Abstract: Therapeutic compositions comprising an indoloquinone compound and various bladder cancer treatments and methods are disclosed. More specifically, the compositions comprise an indoloquinone compound and a formulation vehicle. The formulation vehicle improves the solubility and stability of the indoloquinone compound. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.
Type:
Application
Filed:
August 30, 2013
Publication date:
March 13, 2014
Applicant:
Spectrum Pharmaceuticals, Inc.
Inventors:
Bastiaan Nuijen, Ernie Pfadenhauer, Jos H. Beijnen, Dorla Mirejovsky, Guru Reddy, Luigi Lenaz
Abstract: Anti-cancer coating compositions comprising 3-hydroxymethyl-5-aziridinyl-1-1-methyl-2-[1H-indole-4,7-dione]propenol (E09) are disclosed. More specifically, the coating compositions comprise EO9 and a formulation vehicle. The formulation vehicle improves the solubility and stability of EO9. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.
Type:
Grant
Filed:
June 11, 2012
Date of Patent:
February 11, 2014
Assignee:
Spectrum Pharmaceuticals, Inc.
Inventors:
Bastiaan Nuijen, Ernie Pfadenhauer, Jos H. Beijen
Abstract: Methods and compositions for contributing to the treatment of cancers, especially ovarian tumors, are disclosed. The methods and compositions utilize an endothelin B agonist (ETB) to enhance the delivery and resulting efficacy of chemotherapeutic agent(s) (e.g., cisplatin and/or cyclophosphamide).
Type:
Grant
Filed:
December 7, 2012
Date of Patent:
February 4, 2014
Assignees:
Spectrum Pharmaceuticals, Inc., The Board of Trustees of the University of Illinois
Abstract: Disclosed are methods of treating a chemotherapy-resistant cancer, of treating a cholangiocarcinoma, of treating a metastatic carcinoma, and of treating a transition cell urothelial carcinoma by administering a therapeutically effective amount of an endothelin B (ETB) receptor agonist and a chemotherapeutic agent to a subject afflicted with such a cancer.
Abstract: Therapeutic compositions comprising an indoloquinone compound and various bladder cancer treatments and methods are disclosed. More specifically, the compositions comprise an indoloquinone compound and a formulation vehicle. The formulation vehicle improves the solubility and stability of the indoloquinone compound. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.
Type:
Grant
Filed:
April 8, 2011
Date of Patent:
October 22, 2013
Assignee:
Spectrum Pharmaceuticals, Inc.
Inventors:
Bastiaan Nuijen, Ernie Pfadenhauer, Jos H. Beijnen, Dorla Mirejovsky, Guru Reddy, Luigi Lenaz
Abstract: The present specification provides compositions comprising a thioxanthone-based autophagy inhibitor and/or a cancer therapeutic autophagy inducing compound, pharmaceutical kits comprising these compositions, and methods of treating cancer using such compounds, compositions and kits. Additionally, the present specification provides methods of treating cancer using a thioxanthone-based autophagy inhibitor and a radiotherapy.
Type:
Grant
Filed:
March 8, 2011
Date of Patent:
September 3, 2013
Assignee:
Spectrum Pharmaceuticals, Inc.
Inventors:
Steffan Nawrocki, Jennifer Carew, Guru Reddy
Abstract: Methods for treating cognitive/attention deficit disorders in general using tetrahydroindolone derivatives and analogues, particularly tetrahydroindolone derivatives or analogues in which the tetrahydroindolone derivative or analogue is covalently linked to another moiety to form a bifunctional conjugate are disclosed. More specifically, methods and compositions for treating attention deficit disorder and attention deficit hyperactivity disorders in adults and children as well as mild cognitive impairment and dementia are provided.
Abstract: Methods, compositions and articles of manufacture for contributing to the treatment of cancers, including solid tumors, are disclosed. The methods, compositions and articles of manufacture can utilize an endothelin B agonist (ETB) to enhance the delivery and resulting efficacy of a chemotherapeutic agent.
Abstract: Methods, compositions and articles of manufacture for contributing to the treatment of cancers, including solid tumors, are disclosed. The methods, compositions and articles of manufacture can utilize an endothelin B agonist (ETB) to enhance the delivery and resulting efficacy of a chemotherapeutic agent.
Type:
Application
Filed:
December 11, 2012
Publication date:
April 25, 2013
Applicants:
Spectrum Pharmaceuticals, Inc., The Board of Trustees of the University of Illionis
Inventors:
The Board of Trustees of the University of Illinois, Spectrum Pharmaceuticals, Inc.
Abstract: Methods and compositions for contributing to the treatment of cancers, especially ovarian tumors, are disclosed. The methods and compositions utilize an endothelin B agonist (ETB) to enhance the delivery and resulting efficacy of chemotherapeutic agent(s) (e.g., cisplatin and/or cyclophosphamide).
Type:
Application
Filed:
December 7, 2012
Publication date:
April 25, 2013
Applicants:
Spectrum Pharmaceuticals, Inc., The Board of Trustees of the University of Illinois
Inventors:
The Board of Trustees of the University of Illinois, Spectrum Pharmaceuticals, Inc.