Abstract: A formulation comprising dantrolene, or a pharmaceutically acceptable salt thereof, and a cyclodextrin in a molar ratio of 1:3 to 1:12 and also comprising polyethylene glycol (PEG) with an average molecular weight in the range 1500 to 6000.
Type:
Application
Filed:
May 6, 2022
Publication date:
July 25, 2024
Applicant:
SPEPHARM AG
Inventors:
Samuel SMITH, Luke EDWARDS, Susanna SAUNDERS, Lorenzo MENCUCCINI
Abstract: The present invention relates to an aqueous composition comprising either dantrolene or a pharmaceutically acceptable salt thereof and a cyclodextrin derivative wherein the pH of the aqueous composition is greater than 7. Further, the present invention relates to a powder obtained by drying the inventive composition as well as a kit comprising said inventive powder.
Abstract: An aqueous composition includes either dantrolene or a pharmaceutically acceptable salt thereof and a cyclodextrin derivative, with the pH of the aqueous composition greater than 7. A powder can be obtained by drying the composition. The powder can be included in a kit.