Patents Assigned to SPF Innovations, LLC
-
Patent number: 11633698Abstract: A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.Type: GrantFiled: May 4, 2021Date of Patent: April 25, 2023Assignee: SPF INNOVATIONS, LLCInventors: Gaston de los Reyes, Leon Mir
-
Publication number: 20210252457Abstract: A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.Type: ApplicationFiled: May 4, 2021Publication date: August 19, 2021Applicant: SPF INNOVATIONS, LLCInventors: Gaston de los Reyes, Leon Mir
-
Patent number: 11007483Abstract: A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.Type: GrantFiled: August 22, 2019Date of Patent: May 18, 2021Assignee: SPF INNOVATIONS, LLCInventors: Gaston de los Reyes, Leon Mir
-
Publication number: 20190381458Abstract: A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.Type: ApplicationFiled: August 22, 2019Publication date: December 19, 2019Applicant: SPF Innovations, LLCInventors: Gaston de los Reyes, Leon Mir
-
Patent number: 10421043Abstract: A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.Type: GrantFiled: April 26, 2017Date of Patent: September 24, 2019Assignee: SPF INNOVATIONS, LLCInventors: Gaston de los Reyes, Leon Mir
-
Patent number: 9821274Abstract: A hybrid diafiltration system includes an intermediate tank, a feed pump and a single-pass concentration (SPC) module, feed and product flow diverting valves to affect a multi-step concentration, wash and final-concentration process with fewer recirculation passes than conventional systems.Type: GrantFiled: February 7, 2015Date of Patent: November 21, 2017Assignee: SPF INNOVATIONS LLCInventors: Gaston de los Reyes, Leon Mir
-
Publication number: 20170246591Abstract: A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.Type: ApplicationFiled: April 26, 2017Publication date: August 31, 2017Applicant: SPF INNOVATIONS, LLCInventors: Gaston de los Reyes, Leon Mir
-
Patent number: 9662614Abstract: A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.Type: GrantFiled: April 10, 2014Date of Patent: May 30, 2017Assignee: SPF INNOVATIONS LLCInventors: Gaston de los Reyes, Leon Mir
-
Patent number: 9120037Abstract: Adsorptive bed devices include a scaffold in housing having a stress absorbing rigid structure and open cells filled with adsorptive beads. The scaffold restricts movement of the plurality of adsorptive beads, absorbs compressive stress induced by a hydraulic pressure gradient along a direction of liquid flow and transfers a portion of the induced compressive stress to the housing. In one embodiment the adsorptive bed in packed into a chromatography column, and in another embodiment the adsorptive bed is sealed in a monolithic block.Type: GrantFiled: August 12, 2013Date of Patent: September 1, 2015Assignee: SPF INNOVATIONS, LLCInventor: Gaston de los Reyes
-
Publication number: 20140231331Abstract: A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.Type: ApplicationFiled: April 10, 2014Publication date: August 21, 2014Applicant: SPF INNOVATIONS, LLCInventors: Gaston de los Reyes, Leon Mir
-
Patent number: 8747669Abstract: A separation module and method are disclosed for processing a liquid sample and providing high conversion by operating a single-pass tangential-flow process without a recirculation loop. In one embodiment, the separation module includes three reservoirs and has at least one long, thin channel with a large ratio of channel membrane area to: channel void volume; volume of a sample feed reservoir; and volume of the feed sample. In another embodiment, the separation module includes an external feed reservoir, an external retentate reservoir fluidly and a first vacuum source adapted to apply a first vacuum to the separation element disposed within the housing. The single-pass TFF separation element and single-pass process provides high conversion while operating with relatively low pressure sources. Certain embodiments disclosed herein can be used for the separation of blood.Type: GrantFiled: August 15, 2010Date of Patent: June 10, 2014Assignee: SPF Innovations, LLCInventors: Alex G. Bonner, Gaston de los Reyes
-
Patent number: 8728315Abstract: A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.Type: GrantFiled: March 9, 2012Date of Patent: May 20, 2014Assignee: SPF Innovations, LLCInventors: Gaston de los Reyes, Leon Mir
-
Patent number: 8231787Abstract: A system, method and device are disclosed for bio-processing a feed stream providing a constant output by operating a continuous single-pass tangential-flow process. Embodiments are operated without large circulation pumps. Other embodiments use components which can be disposed after a single use. The system, method and device can also be used to provide constant output diafiltration.Type: GrantFiled: May 5, 2009Date of Patent: July 31, 2012Assignee: SPF Innovations, LLCInventors: Leon Mir, Gaston de los Reyes
-
Patent number: 8231788Abstract: A separation module and method are disclosed for processing a liquid sample and providing high conversion by operating a single-pass tangential-flow process without a recirculation loop. In one embodiment, the separation module includes three reservoirs and has at least one long, thin channel with a large ratio of channel membrane area to: channel void volume; volume of a sample feed reservoir; and volume of the feed sample. In another embodiment, the separation module includes two reservoirs and a hydrophobic vent. The single-pass process provides high conversion while operating with relatively low pressure sources.Type: GrantFiled: February 15, 2009Date of Patent: July 31, 2012Assignee: SPF Innovations, LLCInventors: Leon Mir, Gaston de los Reyes
-
Publication number: 20120168368Abstract: A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.Type: ApplicationFiled: March 9, 2012Publication date: July 5, 2012Applicant: SPF INNOVATIONS, LLCInventors: Gaston de los Reyes, Leon Mir
-
Patent number: 8157999Abstract: A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.Type: GrantFiled: May 15, 2011Date of Patent: April 17, 2012Assignee: SPF Innovations, LLCInventors: Gaston de los Reyes, Leon Mir
-
Publication number: 20110215051Abstract: A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.Type: ApplicationFiled: May 15, 2011Publication date: September 8, 2011Applicant: SPF INNOVATIONS, LLCInventors: Gaston de los Reyes, Leon Mir
-
Patent number: 7967987Abstract: A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.Type: GrantFiled: January 11, 2010Date of Patent: June 28, 2011Assignee: SPF Innovations, LLCInventors: Gaston de los Reyes, Leon Mir
-
Publication number: 20100133185Abstract: A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.Type: ApplicationFiled: January 11, 2010Publication date: June 3, 2010Applicant: SPF INNOVATIONS, LLCInventors: Gaston de los Reyes, Leon Mir
-
Patent number: 7682511Abstract: A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.Type: GrantFiled: May 3, 2008Date of Patent: March 23, 2010Assignee: SPF Innovations, LLCInventors: Gaston de los Reyes, Leon Mir