Abstract: The present invention relates to novel triazine compounds of formula (1). The present invention also discloses compounds of formula I along with other pharmaceutical acceptable excipients and use of the compounds to modulate the PI3K/mTOR pathway.
Type:
Grant
Filed:
July 23, 2013
Date of Patent:
April 25, 2017
Assignee:
SPHAERA PHARMA PTE. LTD.
Inventors:
Sundeep Dugar, Dinesh Mahajan, Frank Hollinger Peter, Amit Sharma, Vinayak Tripathi, Bilash Kuila
Abstract: The present invention relates to novel triazine compounds of formula (1), methods of their preparation, pharmaceutical compositions containing these compounds and the use of these compounds to treat proliferative disorders such as tumors and cancers and also other conditions and disorders related to or associated with dysregulation of PI3 Kinases, PI3 Kinase pathway, mTOR and/or the mTOR pathway.
Type:
Grant
Filed:
January 25, 2012
Date of Patent:
November 1, 2016
Assignee:
Sphaera Pharma PTE. Ltd.
Inventors:
Sundeep Dugar, Dinesh Mahajan, Chandraban Rhushikesh Deokar, Frank Peter Hollinger, Kamal Kishore Kapoor
Abstract: The present invention provides synthetic processes for preparing racemic and/or optically pure epicatechin, epigallocatechin and related polyphenols as such or as their variously functionalized derivatives. A principle objective of the disclosure is to provide a new and useful method of synthesis to obtain polyphenols in isomerically pure and/or racemic forms.
Type:
Grant
Filed:
January 24, 2012
Date of Patent:
August 30, 2016
Assignee:
SPHAERA PHARMA PTE. LTD.
Inventors:
Sundeep Dugar, Dinesh Mahajan, Peter Giannousis Pantelis, Vijay Singh, Kamal Kishore Kapoor
Abstract: The present invention relates to novel triazine compounds of formula (1). The present invention also discloses compounds of formula I along with other pharmaceutical acceptable excipients and use of the compounds to modulate the PI3K/mTOR pathway.
Type:
Application
Filed:
July 23, 2013
Publication date:
July 16, 2015
Applicant:
Sphaera Pharma Pte. Ltd.
Inventors:
Sundeep Dugar, Dinesh Mahajan, Frank Hollinger Peter, Amit Sharma, Vinayak Tripathi, Bilash Kuila
Abstract: Novel compounds and their synthesis are described. Methods for using these compounds in the prevention or treatment of cancer, a bacterial infection or a viral infection in a subject are also described.
Abstract: The present invention provides synthetic processes for preparing racemic and/or optically pure epicatechin, epigallocatechin and related polyphenols as such or as their variously functionalized derivatives. A principle objective of the disclosure is to provide a new and useful method of synthesis to obtain polyphenols in isomerically pure and/or racemic forms.
Type:
Application
Filed:
January 24, 2012
Publication date:
January 30, 2014
Applicant:
SPHAERA PHARMA PTE. LTD.
Inventors:
Sundeep Dugar, Dinesh Mahajan, Pantelis Peter Giannousis, Vijay Singh, Kamal Kishore Kapoor