Abstract: Compositions useful in the controlled delivery of therapeutic agents and their methods of preparation and use are provided. The compositions comprise an optionally oxidized porous silicon core, a layer on the surface of the porous silicon core that comprises a metal silicate, and a therapeutic agent. The compositions optionally further comprise one or more targeting agents and/or cell-penetrating agents to enable the particles to target and enter cells or tissues of interest in a treated subject.
Type:
Application
Filed:
April 14, 2017
Publication date:
June 17, 2021
Applicants:
SPINNAKER BIOSCIENCES, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventors:
Michael J. SAILOR, Jinyoung KANG, Jinmyoung JOO, Emily ANGLIN, Ester KWON, Matthew SKALAK, Sangeeta BHATIA