Abstract: Basic pellets containing erythromycin base, to which a small amount of a slightly acid salt, such as potassium dihydrogen phosphate and possibly an additive is added for improved release of the active substance in the intestinal tract, are provided with a coating that contains a polymer resistant to gastric juice, such as poly(methacrylic acid, -ethylacrylate), a separating agent, such as talc, and a softening agent, such as diethyl phthalate.

Abstract: The novel diclofenac preparation with controlled release is in the form of pellets. The active ingredient, applied to inert pellets, is coated with a membrane layer which contains, in addition to 35-65% by weight of a water-insoluble polymer, 5-20% by weight of at least one water-soluble and/or water-insoluble pore-forming agent and 20-50% by weight of adjuncts. The pore-forming agents permit a very uniform release of diclofenac such that administration twice a day is sufficient. A film coating resistant to gastric juice is applied over the membrane layer.

Abstract: Rapid-release S(+)-ibuprofen pellets are proposed whose bioavailability is comparable to that of commercially available racemate formulations. The rapid release of the active substance is promoted by using small amounts of basic inorganic salts, preferably sodium carbonate, or dilute alkali metal hydroxide solutions. Pellets with an active substance content of 90-99% by weight are obtainable in this way. The pellets are suitable for the application of coatings. Pellets with a protective coating can be compressed directly to tablets in this form and with small amounts of suitable tableting adjuncts. The use of the pharmacologically active S(+)-ibuprofen and of the small amounts of adjuncts required makes it possible to prepare compact pharmaceutical forms.

Abstract: The compact, solid drug preparation, which contains N-acetylcysteine and/or S-(carboxymethyl)-L-cysteine, is suitable, despite small amounts of inactive ingredients, both for swallowing and for sucking or dissolving in water or an aqueous solution. The compactness of the drug preparation is guaranteed by a high proportion of active ingredients--more than 50% of the total weight--and by a suitable choice of a tableting adjuvant.