Abstract: The invention provides novel 6-heterocyclyl-4-morpholin-4-yl-pyridine-2-one compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, diabetes, inflammatory disease, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and A are as defined in the specification.
Type:
Grant
Filed:
October 14, 2021
Date of Patent:
April 23, 2024
Assignee:
Sprint Bioscience AB
Inventors:
Jessica Martinsson, Martin Andersson, Johan Lindström, Rickard Forsblom, Fredrik Rahm, Tobias Ginman, Jenny Viklund
Abstract: The invention provides novel pyridinamine-pyridone and pyrimidinamine-pyridone compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, type II diabetes, inflammatory disease, neurodegenerative disorders, cardiovascular disorders, autoimmune diseases and viral infections; wherein R1, R2, R3 and Z are as defined in the specification.
Type:
Grant
Filed:
November 18, 2021
Date of Patent:
October 10, 2023
Assignee:
Sprint Bioscience AB
Inventors:
Johan Lindström, Rickard Forsblom, Tobias Ginman, Fredrik Rahm, Jenny Viklund
Abstract: The invention provides novel 6-aryl or 6-heteroaryl 4-morpholin-4-yl-pyhdine-2-one compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, diabetes, inflammatory diseases, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and R4 are as defined in the specification.
Type:
Grant
Filed:
June 29, 2021
Date of Patent:
April 25, 2023
Assignee:
Sprint Bioscience AB
Inventors:
Jessica Martinsson, Martin Andersson, Johan Lindström, Rickard Forsblom, Fredrik Rahm, Tobias Ginman, Jenny Viklund
Abstract: The invention provides novel morpholinylpyridone compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, type II diabetes, inflammatory diseases, autoimmune diseases, neurodegenerative disorders, cardiovascular disorders and viral infections; Formula (I) wherein R1, R2 and A are as defined in the specification.
Type:
Grant
Filed:
August 23, 2018
Date of Patent:
January 24, 2023
Assignee:
Sprint Bioscience AB
Inventors:
Johan Lindström, Rickard Forsblom, Jenny Viklund
Abstract: The invention provides novel azaindolylpyridone and diazaindolylpyridone compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, type II diabetes, inflammatory diseases, autoimmune diseases, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R2, R3 and X are as defined in the specification.
Type:
Grant
Filed:
August 23, 2018
Date of Patent:
November 15, 2022
Assignee:
Sprint Bioscience AB
Inventors:
Johan Lindström, Rickard Forsblom, Fredrik Rahm, Jenny Viklund
Abstract: The invention provides novel pyridylpyridone compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, type II diabetes, inflammatory disease, autoimmune diseases, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and X are as defined in the specification.
Type:
Grant
Filed:
August 23, 2018
Date of Patent:
January 11, 2022
Assignee:
Sprint Bioscience AB
Inventors:
Johan Lindström, Rickard Forsblom, Tobias Ginman, Fredrik Rahm, Jenny Viklund
Abstract: The invention provides novel pyridinamine-pyridone and pyrimidinamine-pyridone compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, type II diabetes, inflammatory disease, neurodegenerative disorders, cardiovascular disorders, autoimmune diseases and viral infections; (I) wherein R1, R2, R3 and Z are as defined in the specification.
Type:
Grant
Filed:
August 23, 2018
Date of Patent:
December 28, 2021
Assignee:
Sprint Bioscience AB
Inventors:
Johan Lindström, Rickard Forsblom, Tobias Ginman, Fredrik Rahm, Jenny Viklund
Abstract: The invention provides novel 6-heterocyclyl-4-morpholin-4-yl-pyridine-2-one compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, diabetes, inflammatory disease, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and A are as defined in the specification.
Type:
Grant
Filed:
February 17, 2017
Date of Patent:
November 23, 2021
Assignee:
SPRINT BIOSCIENCE AB
Inventors:
Jessica Martinsson, Martin Andersson, Johan Lindström, Rickard Forsblom, Fredrik Rahm, Tobias Ginman, Jenny Viklund
Abstract: The invention provides novel 6-aryl or 6-heteroaryl 4-morpholin-4-yl-pyhdine-2-one compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, diabetes, inflammatory diseases, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and R4 are as defined in the specification.
Type:
Grant
Filed:
February 17, 2017
Date of Patent:
August 3, 2021
Assignee:
SPRINT BIOSCIENCE AB
Inventors:
Jessica Martinsson, Martin Andersson, Johan Lindström, Rickard Forsblom, Fredrik Rahm, Tobias Ginman, Jenny Viklund