Abstract: The present invention provides novel pharmaceutical compositions comprising -(4-Chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidine and methods of using the same for the treatment of Congenital adrenal hyperplasia (CAH).
Type:
Grant
Filed:
April 26, 2023
Date of Patent:
October 15, 2024
Assignee:
SPRUCE BIOSCIENCES, INC.
Inventors:
Alexis Howerton, Hal Gerber, Michael Huang
Abstract: Polycystic ovary syndrome (PCOS) is characterized by elevated levels of androgens, cysts in the ovaries, and irregular periods. Women with PCOS present with additional symptoms, including hirsutism, alopecia, acne, infertility, weight gain, fatigue, depression and mood changes. The present disclosure provides new compounds, salts, compositions and uses thereof in the treatment of PCOS due to elevated adrenal androgens. Further, the present disclosure provides methods for treating PCOS due to elevated adrenal androgens.
Type:
Grant
Filed:
February 9, 2023
Date of Patent:
September 24, 2024
Assignee:
SPRUCE BIOSCIENCES, INC.
Inventors:
Christopher Barnes, David Karpf, Mustafa Noor
Abstract: The present invention provides novel pharmaceutical compositions comprising -(4-Chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidine and methods of using the same for the treatment of Congenital adrenal hyperplasia (CAH).
Type:
Grant
Filed:
April 26, 2023
Date of Patent:
June 11, 2024
Assignee:
Spruce Biosciences, Inc.
Inventors:
Alexis Howerton, Hal Gerber, Michael Huang
Abstract: Polycystic ovary syndrome (PCOS) is characterized by elevated levels of androgens, cysts in the ovaries, and irregular periods. Women with PCOS present with additional symptoms, including hirsutism, alopecia, acne, infertility, weight gain, fatigue, depression and mood changes. The present disclosure provides new compounds, salts, compositions and uses thereof in the treatment of PCOS due to elevated adrenal androgens. Further, the present disclosure provides methods for treating PCOS due to elevated adrenal androgens.
Type:
Grant
Filed:
June 13, 2023
Date of Patent:
January 2, 2024
Assignee:
Spruce Biosciences, Inc.
Inventors:
Christopher Barnes, David Karpf, Mustafa Noor
Abstract: Described herein are crystalline composition comprising a Corticotropin-releasing hormone receptor 1 (CRF1) antagonist, such as Compound 1: methods of making such crystalline composition, pharmaceutical compositions and medicaments comprising such crystalline composition, and methods of using such crystalline composition in the treatment of conditions, diseases, or disorders that would benefit from modulation of CRF.
Type:
Grant
Filed:
April 13, 2022
Date of Patent:
July 25, 2023
Assignee:
SPRUCE BIOSCIENCES, INC.
Inventors:
Dasharatha Reddy, Ashokraj Rajagopal, Lu Wang, Christopher Barnes
Abstract: The present invention provides novel pharmaceutical compositions comprising-(4-Chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidine and methods of using the same for the treatment of Congenital adrenal hyperplasia (CAH).
Type:
Grant
Filed:
June 25, 2021
Date of Patent:
June 7, 2022
Assignee:
Spruce Biosciences, Inc.
Inventors:
Alexis Howerton, Hal Gerber, Michael Huang
Abstract: The present invention provides novel pharmaceutical compositions comprising -(4-Chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidine and methods of using the same for the treatment of Congenital adrenal hyperplasia (CAH).
Type:
Grant
Filed:
October 5, 2020
Date of Patent:
May 31, 2022
Assignee:
Spruce Biosciences, Inc.
Inventors:
Alexis Howerton, Hal Gerber, Michael Huang
Abstract: The present invention provides novel pharmaceutical compositions comprising -(4-Chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidine and methods of using the same for the treatment of Congenital adrenal hyperplasia (CAH).
Type:
Grant
Filed:
June 25, 2021
Date of Patent:
April 26, 2022
Assignee:
SPRUCE BIOSCIENCES, INC.
Inventors:
Alexis Howerton, Hal Gerber, Michael Huang
Abstract: Provided herein are compounds and pharmaceutical compositions for the prevention and treatment of testicular adrenal rest tumors (TART) or ovarian adrenal rest tumors (OART).
Abstract: The present invention provides novel pharmaceutical compositions comprising -(4-Chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidine and methods of using the same for the treatment of Congenital adrenal hyperplasia (CAH).
Type:
Grant
Filed:
October 22, 2020
Date of Patent:
May 18, 2021
Assignee:
SPRUCE BIOSCIENCES, INC.
Inventors:
Alexis Howerton, Hal Gerber, Michael Huang
Abstract: The present invention provides novel pharmaceutical compositions comprising 3-(4-Chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidine and methods of using the same for the treatment of Congenital adrenal hyperplasia (CAH).
Type:
Application
Filed:
August 14, 2018
Publication date:
May 13, 2021
Applicant:
Spruce Biosciences, Inc.
Inventors:
Alexis HOWERTON, Hal GERBER, Sami KARABORNI
Abstract: The present invention provides novel pharmaceutical compositions comprising -(4-Chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidine and methods of using the same for the treatment of Congenital adrenal hyperplasia (CAH).
Type:
Grant
Filed:
April 18, 2019
Date of Patent:
December 1, 2020
Assignee:
SPRUCE BIOSCIENCES, INC.
Inventors:
Alexis Howerton, Hal Gerber, Michael Huang