Abstract: The present disclosure provides antimicrobial coating compositions that are used to form residual antimicrobial coatings on medical implements and medical devices including the components of medical equipment such as CPAP/BiPAP machines. Antimicrobial coating compositions comprise at least one of an organosilane (R1O)3Si—R2—Z, an organic amine R9R10R11N, a titanium (IV) species, a 1,2-diol, an ?-hydroxy acid, a ?-hydroxy acid, and an organosilane grafted parylene polymer, wherein R1 is H, alkyl, substituted alkyl, aryl or substituted aryl, R2 is a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent, and R9, R10, and R11 are independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.

Abstract: Aqueous coating compositions are disclosed that are capable of forming residual antimicrobial coatings having improved performance related to residual efficacy and duration. In various embodiments, an antimicrobial coating composition comprises at least one antimicrobial compound, at least one durable matrix forming compound, and optionally, at least one performance-enhancing additive. The antimicrobial compound is selected from non-silane quaternary compounds and quaternary silanes. The durable matrix forming compound is selected from polymers, non-polymeric organic compounds, inorganic substances, additional antimicrobial substances, reactive silanes, and non-reactive silanes. The performance-enhancing additive is selected from a polymer, a solvent, an inorganic substance, a surfactant, a crosslinker, a surface modifier, and chemical species capable of forming a sol-gel.

Abstract: Systems, indicator wipe product, and methods thereof used to detect the presence of cationic polymer residues on a surface are described. In various embodiments, the cationic polymer to be detected comprises a quaternary silane residual antimicrobial. The indicator wipe may comprise a woven, nonwoven, or double-knit fabric, cotton, functional cellulose, or open cell foam material substrate impregnated with an aqueous dye solution comprising a sulfonephthalein dye. The indicator wipe may be configured to differentiate between traditional monomer quaternary ammonium compounds and cationic polymers such as quaternary silane compounds used in residual antimicrobial coatings by color changes on the indicator wipe and by observing if cationic-dye complexes diffuse by chromatography on the indicator wipe.

Abstract: A method of quantifying an antimicrobial coatings using a handheld XRF analyzer is disclosed. The method provides an estimate of the expected level of antimicrobial efficacy for a thin film comprising silicon and/or titanium by obtaining a 14Si or 22Ti peak intensity using XRF spectroscopy and converting the obtained 14Si or 22Ti peak intensity to the expected level of efficacy using a calibration curve. A properly calibrated handheld XRF analyzer allows a user to assess the viability of antimicrobial coatings in the field, such as in a hospital where various fomites may be coated with silane and/or titanium compositions.