Patents Assigned to SS Pharmaceutical Co., Ltd.
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Publication number: 20020098487Abstract: Nucleic acids for detecting fungi, which have sequences shown in SEQ ID NOs. 3, 57 to 75 are disclosed. The nucleic acids for detecting fungi may be used as probes or primers for gene amplification. In case of using them as primers, detection and identification of fungi belonging to the genus Aspergillus may be attained because the sizes of the amplified nucleic acid fragments vary depending on the species of the fungi belonging to the genus Aspergillus if the primers are appropriately selected.Type: ApplicationFiled: March 16, 2001Publication date: July 25, 2002Applicant: SS Pharmaceutical Co., Ltd.Inventors: Koji Yokoyama, Li Wang
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Patent number: 6174900Abstract: Disclosed herein is a substituted piperidine derivative represented by the following general formula (1): wherein R1 means an aryl or heteroaryl group which may have at least one substituent, R2 denotes an alkyl, alkenyl or aralkyl group, R3 stands for a hydrogen atom or an alkyl group, and R4 is a hydrogen atom, an alkyl group, or an aryl, heteroaryl, aralkyl, aralkenyl or heteroaralkyl group which may have at least one substituent, or a salt thereof. A medicine including this compound is also disclosed. The compound has excellent anticholinergic effect and calcium antagonism and inhibits reflex bladder contraction and is hence useful for prophylaxis of and treatment for a urinary disturbance such as pollakiuria.Type: GrantFiled: June 14, 1999Date of Patent: January 16, 2001Assignee: SS Pharmaceutical Co., Ltd.Inventors: Tomomi Okada, Fujiko Konno, Terumitsu Kaihoh, Masago Ishikawa, Yoshinori Takahashi, Hiroyuki Mizuno, Haruyoshi Honda, Susumu Sato, Hideaki Matsuda
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Patent number: 6171520Abstract: Disclosed are SH-labeling reagents containing acridine compounds represented by the following formula (I): wherein A represents the following group: —(CH2)m1— or —(CH2)m2—Q—(CH2)n— in which Q represents a group —S+RX−—, a group —N+RR1X−— wherein R1 represents an alkyl group having 1 to 6 carbon atoms or an aryl group, a group wherein R2 and R3 may be the same or different and are each independently a group —(CH2)k— (k: a number of 1 to 3) or —O(CH2CH2O)l— (l: a number of 1 to 3), m1 stands for a number of 1 to 6, m2 denotes a number of 0 to 2, n means a number of 1 to 2; R represents an alkyl group having 1 to 6 carbon atoms or an aryl group; and X− represents an anion, or intermediates thereof; preparation processes of the acridine compounds; and methods for labeling analytes by using the compounds.Type: GrantFiled: November 14, 1997Date of Patent: January 9, 2001Assignee: SS Pharmaceutical Co., Ltd.Inventors: Kazuhiro Imai, Hiromichi Eto, Takeshi Kotsugai, Tadashi Narita
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Patent number: 6103538Abstract: Disclosed herein is a method for the detection of a target substance by a colloidal gold immunoassay, which comprises dissolving in an immunoreaction system a metal salt selected from the group consisting of sodium, potassium and lithium fluorides, sodium, potassium, lithium and magnesium iodides, sodium, potassium, lithium and magnesium bromides, lithium and magnesium chlorides, sodium, potassium, lithium and magnesium nitrates, sodium, potassium, lithium and magnesium sulfates, sodium, potassium, lithium and magnesium formates, sodium, potassium, lithium and magnesium acetates, and mixtures of at least two of these metal salts, whereby the metal salt is allowed to exist in a reaction mixture.Type: GrantFiled: December 22, 1997Date of Patent: August 15, 2000Assignee: SS Pharmaceutical Co., Ltd.Inventor: Takeshi Kotsugai
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Patent number: 6063945Abstract: A compound having formula (2): ##STR1## wherein R represents hydrogen, a straight or branched C.sub.1-10 alkyl group, a C.sub.7-11 aralkyl group or a C.sub.2-10 carboacyl group and m stands for 1 to 5.Type: GrantFiled: June 8, 1999Date of Patent: May 16, 2000Assignee: SS Pharmaceutical Co., Ltd.Inventors: Minoru Tokizawa, Sunao Takeda, Yasushi Kaneko, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato, Hideaki Matsuda
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Patent number: 6046218Abstract: Described is a pyridine derivative represented by the following formula (1): ##STR1## wherein R.sup.1 and R.sup.2 individually represent H, an alkyl group, a cycloalkyl group, a hydroxyalkyl group, an alkoxyalkyl group which may have a substituent, a carboxyalkyl group, an alkoxycarbonylalkyl group, an aralkyl group which may have a substituent, a phenacyl group or an acyl group, R.sup.3 represents an alkyl group, a phenyl group which may have a substituent, a heteroaryl group or a cyclic amino group, X represents O or combination of OH and H, or a salt thereof; and a medicament, such as cytokine production suppressant, comprising the derivative or salt thereof as an effective ingredient. The invention compound has potential, highly specific and highly safe immunoregulating capacity so that it can suppress the excessive production of a specific cytokine in various diseases related to the immune system.Type: GrantFiled: November 17, 1997Date of Patent: April 4, 2000Assignee: SS Pharmaceutical Co., Ltd.Inventors: Hiroshi Hasegawa, Tadashi Mikami, Koichi Tachibana, Kazuo Yamazaki, Noriyuki Kawamoto, Noriaki Shioiri, Koji Kusano, Susumu Sato, Hideaki Matsuda, Toshio Yokoyama
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Patent number: 6002028Abstract: Described is a triazole derivative represented by the formula (1) or salt thereof, preparation process thereof, preparation intermediates represented by the formulas (2) and (3), and a pharmaceutical comprising the compound represented by the formula (1) or salt thereof. ##STR1## wherein n stands for 0, 1 or 2, X.sup.1 represents H or F and Y.sup.1 and Y.sup.2 each independently represents H, halogen or CF.sub.3.Type: GrantFiled: May 14, 1999Date of Patent: December 14, 1999Assignee: SS Pharmaceutical Co., Ltd.Inventors: Minoru Tokizawa, Sunao Takeda, Yasushi Kaneko, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato, Hideaki Matsuda
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Patent number: 5986144Abstract: Described is a triazole derivative represented by the formula (1) or salt thereof, preparation process thereof, preparation intermediates represented by the formulas (2) and (3), and a pharmaceutical comprising the compound represented by the formula (1) or salt thereof. wherein n stands for 0, 1 or 2, X.sup.1 represents H or F and Y.sup.1 and Y.sup.2 each independently represents H, halogen or CF.sub.3.Type: GrantFiled: May 14, 1999Date of Patent: November 16, 1999Assignee: SS Pharmaceutical Co., Ltd.Inventors: Minoru Tokizawa, Sunao Takeda, Yasushi Kaneko, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato, Hideaki Matsuda
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Patent number: 5968956Abstract: Disclosed herein is a substituted piperidine derivative represented by the following general formula (1): ##STR1## wherein R.sup.1 means an aryl or heteroaryl group which may have at least one substituent, R.sup.2 denotes an alkyl, alkenyl or aralkyl group, R.sup.3 stands for a hydrogen atom or an alkyl group, and R.sup.4 is a hydrogen atom, an alkyl group, or an aryl, heteroaryl, aralkyl, aralkenyl or heteroaralkyl group which may have at least one substituent, or a salt thereof. A medicine including this compound is also disclosed. The compound has excellent anticholinergic effect and calcium antagonism and inhibits reflex bladder contraction and is hence useful for prophylaxis of and treatment for a urinary disturbance such as pollakiuria.Type: GrantFiled: June 26, 1996Date of Patent: October 19, 1999Assignee: SS Pharmaceutical Co., Ltd.Inventors: Tomomi Okada, Fujiko Konno, Terumitsu Kaihoh, Masago Ishikawa, Yoshinori Takahashi, Hiroyuki Mizuno, Haruyoshi Honda, Susumu Sato, Hideaki Matsuda
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Patent number: 5945438Abstract: Described is a triazole derivative represented by the formula (1) or salt thereof, preparation process thereof, preparation intermediates represented by the formulas (2) and (3), and a pharmaceutical comprising the compound represented by the formula (1) or salt thereof. ##STR1## wherein n stands for 0, 1 or 2, X.sup.1 represents H or F and Y.sup.1 and Y.sup.2 each independently represents H, halogen or CF.sub.3.Type: GrantFiled: December 17, 1996Date of Patent: August 31, 1999Assignee: SS Pharmaceutical Co., Ltd.Inventors: Minoru Tokizawa, Sunao Takeda, Yasushi Kaneko, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato, Hideaki Matsuda
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Patent number: 5939448Abstract: Described is a triazole derivative represented by the formula (1): wherein R represents a hydrogen atom, an alkyl group, an aralkyl group or an acyl group, n stands for 0 to 2 and m stands for 1 to 5 or salt thereof, and a pharmaceutical containing the derivative or salt as an effective ingredient.Type: GrantFiled: June 10, 1997Date of Patent: August 17, 1999Assignee: SS Pharmaceutical Co., Ltd.Inventors: Minoru Tokizawa, Sunao Takeda, Yasushi Kaneko, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato, Hideaki Matsuda
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Patent number: 5935977Abstract: The present invention relates to a substituted vinylpyridine derivative represented by the following formula (1): ##STR1## (wherein R.sup.1 represents a hydrogen atom, an alkyl group, etc., R.sup.2 represents an alkyl group; one of R.sup.3 and R.sup.4, which are different from each other, represents a hydrogen atom and the other represents a nitrile group, R.sup.5 represents an aryl group or a heteroaryl group, X represents an oxygen atom, etc., and one of Q.sup.1, Q.sup.2, and Q.sup.3 represents a nitrogen atom and the other two represent CH); a salt of the derivative; and a drug containing the derivative or salt as the active ingredient. Due to strong PDE inhibitory action and TNF-.alpha. production inhibitory action, the derivative, salt, and drug are useful for the prevention and treatment of a wide variety of inflammatory diseases and autoimmune diseases.Type: GrantFiled: May 26, 1998Date of Patent: August 10, 1999Assignee: SS Pharmaceutical Co., Ltd.Inventors: Kazuo Yamazaki, Yoichiro Ogawa, Hidehiko Kohya, Tadashi Mikami, Noriyuki Kawamoto, Noriaki Shioiri, Hiroshi Hasegawa, Susumu Sato
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Patent number: 5922767Abstract: Disclosed herein are substituted benzylurea derivatives represented by the following general formula (1): ##STR1## wherein R.sup.1 and R.sup.2 are independently H, a halogen atom, or an alkyl or alkoxyl group, R.sup.3 is a phenyl or heterocyclic group which may be substituted, n is an integer of 1-6, and R.sup.4 is a phenyl group which may be substituted, or salts thereof, and medicines comprising such a derivative as an active ingredient. The derivatives or salts thereof strongly inhibit only ACAT in macrophages and are hence useful as prophylactic and therapeutic agents for arteriosclerosis.Type: GrantFiled: October 7, 1997Date of Patent: July 13, 1999Assignee: SS Pharmaceutical Co., Ltd.Inventors: Yoshihiko Kanamaru, Hiroyuki Hirota, Akihiro Shibata, Teruo Komoto, Hiroyuki Naito, Koichi Tachibana, Mari Ohtsuka, Fumio Ishii, Susumu Sato
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Patent number: 5902826Abstract: A diamine-platinum (IV) complex represented by the following formula (1): ##STR1## wherein R.sup.1 and R.sup.2 together represent R.sup.5 O--CH(CH.sub.2 NH.sub.2).sub.2 (R.sup.5 represents hydrogen, acetyl, trifluoroacetyl, benzoyl, cycloalkylcarbonyl or methanesulfonyl) or a C.sub.5-8 1,2-cycloalkanediamine; R.sup.3 and R.sup.4 each represents hydrogen or R.sup.6 CO-- (R.sup.6 represents alkyl, halogenoalkyl, cycloalkyl, aryl or aralkyl); and two X's together represent a malonic acid residue or glycolic acid residue which may have a substituent capable of coordinating to the platinum in formula (1) by an O,O-coordination or an N-acylamino acid residue coordinating to the platinum in formula (1) by an O,N-coordination; and a pharmaceutical composition comprising as an active ingredient the above-described diamine-platinum (IV) complex.Type: GrantFiled: December 23, 1997Date of Patent: May 11, 1999Assignee: SS Pharmaceutical Co., Ltd.Inventors: Kinichi Mogi, Hidehiko Koya, Mari Ohtsuka, Hiroyuki Mizuno, Susumu Sato
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Patent number: 5866609Abstract: Disclosed herein are substituted vinylurea derivatives represented by the following general formula (1): ##STR1## wherein R.sup.1 and R.sup.3 are independently a phenyl group which may be substituted, R.sup.2 is a phenyl group which may be substituted, or a cycloalkyl group, and wave lines mean that the bonding state may be either E or Z, with the proviso that the cases where R.sup.1, R.sup.2 and R.sup.3 are unsubstituted phenyl groups, and where R.sup.1 and R.sup.2 are unsubstituted phenyl groups and R.sup.3 is a 4-ethoxyphenyl group are excluded, or salt thereof, and medicines comprising such a derivative as an active ingredient as well as a method of preventing and treating arteriosclerosis with such a medicine. The derivatives or salts thereof selectively and strongly inhibit ACAT in macrophages and are hence useful as prophylactic and therapeutic agents for arteriosclerosis.Type: GrantFiled: July 24, 1997Date of Patent: February 2, 1999Assignee: SS Pharmaceutical Co., Ltd.Inventors: Yoshihiko Kanamaru, Hiroyuki Hirota, Akihiro Shibata, Teruo Komoto, Hiroyuki Naito, Koichi Tachibana, Mari Ohtsuka, Fumio Ishii, Susumu Sato
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Patent number: 5789419Abstract: This invention relates to a 4-quinolinone derivative represented by the following general formula (1): ##STR1## wherein R.sup.1 and R.sup.2 mean individually H, halogen, cyano, or lower alkyl, lower alkylsulfonyl, lower alkylsulfinyl, lower alkylthio or lower alkoxy which may be substituted by halogen, or phenylsulfonyl, phenylsulfinyl or phenylthio which may have a substituent; and R.sup.3 and R.sup.4 denote individually H, lower alkyl or cycloalkyl which may be substituted by halogen, or pyridyl, furanyl or phenyl which may have a substituent, or R.sup.3 and R.sup.4 may form a 4-, 5- or 6-membered heterocyclic ring, or a salt thereof, and an intermediate useful for the preparation thereof, and besides a medicinal composition comprising this compound as an active ingredient. The compound (1) or the salt thereof has an excellent potassium channel-activating effect and is useful as, for example, a prophylactic and therapeutic agent for diseases of circulatory and bronchial systems.Type: GrantFiled: December 9, 1996Date of Patent: August 4, 1998Assignee: SS Pharmaceutical Co., Ltd.Inventors: Kazuo Yamazaki, Shigeru Adegawa, Yoichiro Ogawa, Hideaki Matsuda, Tadayuki Kuraishi
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Patent number: 5710152Abstract: A benzoazine derivative represented by the following formula (1), ##STR1## wherein R.sup.1 represents an alkyl group, alkoxy group, halogen atom, halogenoalkyl group, amino group, hydroxy group, benzyloxy group which may have a substituent, cyano group, carbamoyl group, acyl group, nitro group, carboxy group, or sulfonamide group; R.sup.2 and R.sup.3 may be the same or different and each individually represents a hydrogen atom or an alkyl group, or R.sup.2 and R.sup.3 indicate in combination an alkylene group having 2-7 carbon atoms; R.sup.4 and R.sup.5 may be the same or different and each individually represents a hydrogen atom or an alkyl group; X denotes O, S, or N--R.sup.6 (wherein R.sup.6 represents a hydrogen atom, an alkyl group, or an aryl group or pyridyl group which may have a substituent); m is an integer from 0 to 4; and n is an integer from 1 to 3, or a salt of the benzoazine derivative.Type: GrantFiled: January 30, 1997Date of Patent: January 20, 1998Assignee: SS Pharmaceutical Co., Ltd.Inventors: Yoshihiro Nagao, Yoshikuni Ito, Jiro Kotake, Tadayuki Kouda, Haruyoshi Honda, Susumu Sato, Hideaki Matsuda
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Patent number: 5707878Abstract: A method for detecting blood component in a sample comprising reacting a human erythrocyte membrane band 3 glycoprotein (band 3) in the sample and a hemagglutinin produced by a microorganism belonging to the genus Conidiobolus (CA) and measuring said band 3 glycoprotein contained in a complex produced by the reaction. Because band 3 can be detected specifically, at high sensitivity, and stably by the use of CA, the method ensures qualitative or quantitative, and accurate detection of human blood component in feces or contents of digestive organs, of which the determination of the presence or quantity of human blood component by hemoglobin is difficult.Type: GrantFiled: June 26, 1995Date of Patent: January 13, 1998Assignee: SS Pharmaceutical Co., Ltd.Inventors: Tetsuo Tomiyama, Tadashi Narita, Takeshi Kotsugai, Shigeo Narita
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Patent number: 5676970Abstract: An anti-inflammatory analgesic plaster carries thereon a base which comprises piroxicam and a polyoxyethylene nonionic surfactant having 5-15 moles of added ethylene oxide.Type: GrantFiled: October 11, 1995Date of Patent: October 14, 1997Assignee: SS Pharmaceutical Co., Ltd.Inventors: Hirohisa Okuyama, Yasuo Ikeda, Shigenori Otsuka, Shuichi Kasai, Akira Iwasa
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Patent number: 5654002Abstract: A process is provided for the production of piroxicam tablets. According to the process, a solution of a water-soluble high-molecular substance is added to a mixture of piroxicam and lactose. The resultant mixture is granulated and then compressed into tablets.Type: GrantFiled: June 6, 1995Date of Patent: August 5, 1997Assignee: SS Pharmaceutical Co., Ltd.Inventors: Hideyoshi Kanbe, Youichi Nakajima, Akira Iwasa