Patents Assigned to St. Joseph' Children' Hospital
  • ANTIMICROBIAL PROTEIN COMPOSITIONS AND USES THEREOF
    Publication number: 20120289456
    Abstract: Several bacterial species were isolated from marine segment obtained from seabed sediment at depths exceeding 1700 feet. At least four of the bacteria produced a compound that showed antibacterial activity against one or more multiple-drug-resistant (MDR) bacteria isolated from hospitals and clinics. One isolate, SJCH-12, exhibited a broad range of activity against MDR strains tested, including methicillin resistant Staphylococcus aureus (MRSA).
    Type: Application
    Filed: February 10, 2012
    Publication date: November 15, 2012
    Applicant: ST. JOSEPH'S CHILDREN'S HOSPITAL
    Inventors: MICHAEL J. P. LAWMAN, Selena Savell, Shabnam Eidizadeh
  • Antimicrobial protein compositions and production thereof from marine bacteria
    Patent number: 8114657
    Abstract: Several bacterial species were isolated from marine segment obtained from seabed sediment at depths exceeding 1700 feet. At least four of the bacteria produced a compound that showed antibacterial activity against one or more multiple-drug-resistant (MDR) bacteria isolated from hospitals and clinics. One isolate, SJCH-12, exhibited a broad range of activity against MDR strains tested, including methicillin resistant Staphylococcus aureus (MRSA).
    Type: Grant
    Filed: August 24, 2009
    Date of Patent: February 14, 2012
    Assignee: St. Joseph' Children' Hospital
    Inventors: Michael Lawman, Selena Braccili, Shabnam Eidizadeh
  • ANTIMICROBIAL PROTEIN COMPOSITIONS AND PRODUCTION THEREFOR FROM MARINE BACTERIA
    Publication number: 20110160124
    Abstract: Several bacterial species were isolated from marine segment obtained from seabed sediment at depths exceeding 1700 feet. At least four of the bacteria produced a compound that showed antibacterial activity against one or more multiple-drug-resistant (MDR) bacteria isolated from hospitals and clinics. One isolate, SJCH-12, exhibited a broad range of activity against MDR strains tested, including methicillin resistant Staphylococcus aureus (MRSA).
    Type: Application
    Filed: August 24, 2009
    Publication date: June 30, 2011
    Applicant: St. Joseph's Children's Hospital
    Inventors: Michael Lawman, Selena Braccili, Shabnam Eidizadeh
  • Modulating cancer cell characteristics
    Patent number: 7666676
    Abstract: The hedgehog pathway in cerebellar cancer cells was modulated with siRNA specifically targeted to the shh and gli-I genes. Silencing of the two genes in a medullablastoma cell line transfected with the siRNAs caused significant reduction of mRNA specific for the targeted shh and gli-I genes and a loss of protein expression. The disclosed methods and compositions may be useful for treatment of a range of primitive neuroectodermal tumors (PNET) by shutting down or modulating the expression of gene products associated with the hedgehog pathway.
    Type: Grant
    Filed: May 16, 2006
    Date of Patent: February 23, 2010
    Assignee: St. Joseph's Children's Hospital
    Inventors: Michael J. P. Lawman, Selena Braccili